gene

RAB5A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAB5A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

33Connections

0Hypotheses

0Analyses

19Outgoing

14Incoming

0Experiments

0Debates

Summary

RAB5A is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, interacts with. Associated with ALS, Als, Ms. Connected to 31 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	RAB5A
Full Name	Ras-Related Protein Rab-5A
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	24 kDa
Amino Acids	218 aa
Pathways	MAPK signaling
Ensembl ID	ENSG00000108510
GeneCards	RAB5A
Human Protein Atlas	RAB5A
GTPase-Activating Proteins (GAPs)	RabGAP5 and other GAPs accelerate GTP hydrolysis, returning RAB5A to its inactive state
Enlarged Early Endosomes	Observed in Down syndrome brain and familial AD cases, preceding other pathology
RAB5 Overactivity	Increased RAB5A expression and activity contributes to endosomal enlargement
Cargo Sorting Defects	Impaired trafficking of APP, BACE1, and Aβ-generating enzymes
Associated Diseases	Als
Interactions	NEURODEGENERATIVE DISEASES
KG Connections	32 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    RAB5A["RAB5A"]
    Als{"Als"}
    RAB5A -->|"associated with"| Als
    RAB5A -->|"therapeutic target"| Als
    Ms{"Ms"}
    RAB5A -->|"interacts with"| Ms
    ALS{"ALS"}
    RAB5A -->|"associated with"| ALS
    RAB11B["RAB11B"]
    RAB5A -->|"associated with"| RAB11B
    RAB10["RAB10"]
    RAB5A -->|"associated with"| RAB10
    RAB3A["RAB3A"]
    RAB5A -->|"associated with"| RAB3A
    Exocytosis(["Exocytosis"])
    RAB5A -->|"associated with"| Exocytosis
    RAB5["RAB5"]
    RAB5A -->|"associated with"| RAB5
    RAB27B["RAB27B"]
    RAB5A -->|"associated with"| RAB27B
    HSPA1A["HSPA1A"]
    RAB5A -->|"therapeutic target"| HSPA1A
    RAB8A["RAB8A"]
    RAB5A -->|"therapeutic target"| RAB8A
    RAB4B["RAB4B"]
    RAB4B -->|"associated with"| RAB5A
    RAB27B -->|"associated with"| RAB5A
    RAB3C["RAB3C"]
    RAB3C -->|"associated with"| RAB5A
    RAB5 -->|"associated with"| RAB5A
    RAB3B["RAB3B"]
    RAB3B -->|"associated with"| RAB5A
    RAB3A -->|"associated with"| RAB5A
    RAB10 -->|"associated with"| RAB5A
    RAB11B -->|"associated with"| RAB5A
    RAB7A["RAB7A"]
    RAB7A -->|"therapeutic target"| RAB5A
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    NEURODEGENERATIVE_DISEASES -->|"interacts with"| RAB5A
    IGF2R["IGF2R"]
    IGF2R -->|"therapeutic target"| RAB5A
    CAPZB["CAPZB"]
    CAPZB -->|"therapeutic target"| RAB5A
    style RAB5A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (19)

Target	Relation	Type	Str
Als	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Als	therapeutic_target	disease	0.65
Ms	interacts_with	disease	0.65
RAB10	associated_with	gene	0.60
RAB3A	associated_with	gene	0.60
RAB11B	associated_with	gene	0.60
RAB27B	associated_with	gene	0.60
Exocytosis	associated_with	pathway	0.60
RAB5	associated_with	gene	0.60
RAB3B	associated_with	gene	0.60
RAB3C	associated_with	gene	0.60
RAB4B	associated_with	gene	0.60
Synaptic Vesicle	associated_with	pathway	0.60
AND	associated_with	gene	0.60
HSPA1A	therapeutic_target	gene	0.60
RAB8A	therapeutic_target	gene	0.60
CANX	therapeutic_target	gene	0.60
HSPA5	therapeutic_target	gene	0.60

Incoming (14)

Source	Relation	Type	Str
CHAT	interacts_with	gene	0.80
RAB10	associated_with	gene	0.60
RAB11B	associated_with	gene	0.60
RAB3A	associated_with	gene	0.60
IGF2R	therapeutic_target	gene	0.60
CAPZB	therapeutic_target	gene	0.60
RAB7A	therapeutic_target	gene	0.60
RAB4B	associated_with	gene	0.60
RAB27B	associated_with	gene	0.60
RAB3C	associated_with	gene	0.60
RAB5	associated_with	gene	0.60
RAB3B	associated_with	gene	0.60
NEURODEGENERATIVE DISEASES	interacts_with	gene	0.60
AND	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RAB5A in their description or question text

No additional research found