protein

BACE2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BACE2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

61Connections

0Hypotheses

0Analyses

32Outgoing

29Incoming

0Experiments

0Debates

Summary

BACE2 is a protein involved in neurodegeneration research. Key relationships include: therapeutic target, treats, implicated in. Associated with Als, Alzheimer. Connected to 10 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	BACE2
Full Name	Beta-Secretase 2
Chromosome	21q22.3
Protein Type	Protease
Function	BACE2 is a member of the aspartyl protease family and shares 64% sequence homology with BACE1.
Primary Expression	various tissues including brain, pancreas, and heart
Amino Acids	518 aa
Pathways	Notch
UniProt ID	Q15120
Ensembl ID	ENSG00000182240
GeneCards	BACE2
Human Protein Atlas	BACE2
BACE1 Gene	Homologous protease with dominant role in amyloid-beta generation
Amyloid Precursor Protein (APP)	Primary substrate shared with BACE1
Neuregulin-1	BACE2-cleaved growth factor crucial for neuronal survival
Associated Diseases	Als, Alzheimer
Interactions	AD, APOE, APP, AΒ, BACE1, CHAT
KG Connections	61 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: BACE2 — AlphaFold Q15120 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

BACE2 Gene

gene · 635 words

→

BACE2 Protein

protein · 594 words

→

Pathway Diagram

flowchart TD
    N0["BACE2"]
    N1["Als"]
    N0 -->|"associated with"| N1
    N2["Alzheimer"]
    N0 -->|"therapeutic target"| N2
    N3["BACE1"]
    N0 -->|"treats"| N3
    N4["ALZHEIMER"]
    N0 -->|"therapeutic target"| N4
    N5["PRESENILIN"]
    N0 -->|"therapeutic target"| N5
    N6["AMYLOID"]
    N0 -->|"therapeutic target"| N6
    N7["GENES"]
    N0 -->|"therapeutic target"| N7
    N8["ALZHEIMER'S DISEASE"]
    N0 -->|"therapeutic target"| N8
    N9["APP"]
    N0 -->|"therapeutic target"| N9
    N10["neurodegeneration"]
    N0 -->|"implicated in"| N10

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 disease
    class N2 disease
    class N3 gene
    class N4 gene
    class N5 gene
    class N6 gene
    class N7 gene
    class N8 gene
    class N9 gene

Outgoing (32)

Target	Relation	Type	Str
Alzheimer	degrades	disease	0.65
Als	associated_with	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
ALS	degrades	disease	0.65
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
Myelination	degrades	pathway	0.60
Neurogenesis	contributes_to	pathway	0.60
Amyloid	degrades	pathway	0.60
STING	protects_against	gene	0.60
PRESENILIN	therapeutic_target	gene	0.60
AMYLOID	therapeutic_target	gene	0.60
GENES	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
PSEN1	protects_against	gene	0.60
CHAT	activates	gene	0.60
NEURON	associated_with	cell_type	0.60
NEURON	co_discussed	cell_type	0.60
NEURONS	co_discussed	cell_type	0.60
NCSTN	regulates	gene	0.60
Alzheimer	associated_with	disease	0.60
PSEN2	regulates	gene	0.60
ALS	associated_with	disease	0.60
PEN2	regulates	gene	0.60
PSEN1	regulates	gene	0.60
BACE1	degrades	gene	0.60
oxidative stress response	participates_in	pathway	0.60
PSEN1	associated_with	gene	0.60
PSEN2	associated_with	gene	0.60
BACE1	treats	gene	0.60
APP	therapeutic_target	gene	0.60
Neuron	expressed_in	cell_type	0.55
neurons	expressed_in	cell_type	0.55

Incoming (29)

Source	Relation	Type	Str
APOE	activates	gene	0.70
BACE1	expresses	gene	0.70
APP	activates	gene	0.70
BACE1	degrades	gene	0.70
BACE1	associated_with	gene	0.70
APP	degrades	gene	0.60
AΒ	activates	gene	0.60
AD	inhibits	gene	0.60
BACE1	biomarker_for	gene	0.60
AD	regulates	gene	0.60
AD	activates	gene	0.60
BACE1	interacts_with	gene	0.60
ADAM10	regulates	gene	0.60
APH1B	regulates	gene	0.60
APP	regulates	gene	0.60
BACE1	regulates	gene	0.60
BACE1	inhibits	gene	0.60
APP	cleaves	gene	0.60
BACE1	targets	gene	0.60
AΒ	co_discussed	gene	0.60
AΒ	degrades	gene	0.60
AΒ	enhances	gene	0.60
BACE1	enhances	gene	0.60
AΒ	inhibits	gene	0.60
AD	protects_against	gene	0.60
BACE1	co_discussed	gene	0.45
ADAM10	co_discussed	gene	0.40
APOE	co_discussed	gene	0.40
APP	co_discussed	gene	0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning BACE2 in their description or question text

No additional research found