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gene 1,171 words KG: CHAT
Contents

CHAT Gene

🧬 Gene Info
Gene SymbolCHAT
Chromosome10q11.23
FunctionThe reaction mechanism involves
Subcellular Localizationthe cytoplasm of presynaptic nerve terminals, but also associates with synaptic vesicles for regulated neurotransmitter
Molecular Weight70 kDa
Amino Acids748 aa
Exons14
PathwaysApoptosis, Cell Cycle
GeneCardsCHAT
Human Protein AtlasCHAT
Associated DiseasesAls, Alzheimer, Alzheimer's disease, Anxiety, Dementia
InteractionsABCB1, ACHE, AD, AKT, ALZHEIMER, ALZHEIMER'S DISEASE
SciDEX HypothesesSensory-Motor Circuit Cross-Modal Compensation
KG Connections391 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (26)

Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain A
Score: 0.67Noradrenergic-Tau Propagation Blockade
Score: 0.71CYP46A1 Overexpression Gene Therapy
Score: 0.92Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.91Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82

Related Analyses (15)

Do β-amyloid plaques and neurofibrillary tangles cause or re
neurodegeneration · completedCircuit-level neural dynamics in neurodegeneration
neuroscience · completedSenolytic therapy for age-related neurodegeneration
neurodegeneration · archivedNeuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archivedLipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

Related Experiments (2)

Electroacupuncture ST37 treatment for DSS-induced colitis in
validation · proposed · Score: 0.95Creation and validation of 3xAD-ChAT-Cre mouse model
validation · proposed · Score: 0.90

See Also (7)

acetylcholine
general · KG edge: co_discussedABCB1 (MDR1) - ATP Binding Cassette Subfamily B Member
gene · KG edge: associated_withABCG2 (BCRP) - ATP Binding Cassette Subfamily G Member
gene · KG edge: associated_withACE Gene
gene · KG edge: therapeutic_targetADRA2A Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

MAOB associated_with CHAT
GABRA1 associated_with CHAT
CHAT associated_with CYP2D6
CHAT associated_with APOE
CHAT associated_with HMGCR
CHAT associated_with OPRM1
CHAT associated_with SLC30A8
CHAT associated_with COMT
CHAT associated_with NBEA
CHAT associated_with HTR2C

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