concept

B CELL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about B CELL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

538Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

1Experiments

0Debates

Summary

B CELL is a concept in neurodegeneration research. Key relationships include: co discussed, activates, inhibits. Associated with GLIOBLASTOMA, LYMPHOMA, TUMOR. Connected to 30 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	B CELL
Key Genes/Proteins	AMPK, AQP4, BCL2
Related Diseases	CANCER

Pathway Diagram

graph TD
    B_CELL["B CELL"]
    TCR["TCR"] -->|"expressed in"| B_CELL
    CD40["CD40"] -->|"expressed in"| B_CELL
    CANCER["CANCER"] -->|"expressed in"| B_CELL
    AQP4["AQP4"] -->|"expressed in"| B_CELL
    COMPLEMENT["COMPLEMENT"] -->|"expressed in"| B_CELL
    ASTROCYTES["ASTROCYTES"] -->|"expressed in"| B_CELL
    CD19["CD19"] -->|"expressed in"| B_CELL
    ASTROCYTE["ASTROCYTE"] -->|"expressed in"| B_CELL
    NEUROINFLAMMATION["NEUROINFLAMMATION"] -->|"expressed in"| B_CELL
    AQUAPORIN_4["AQUAPORIN-4"] -->|"expressed in"| B_CELL

Outgoing (128)

Target	Relation	Type	Str
ST6Gal1	expressed_in	enzyme	0.90
Neuromyelitis Optica Spectrum Disorder	associated_with	disease	0.90
NEUROMYELITIS OPTICA SPECTRUM DISORDER	involved_in	entity	0.90
Igg	expressed_in	protein	0.90
Aqp4-Igg	associated_with	biomarker	0.88
Neuromyelitis optica spectrum disorder activity	biomarker_for	disease	0.80
P53	inhibits	gene	0.65
BCL2	regulates	gene	0.65
LYMPHOMA	causes	disease	0.65
CANCER	inhibits	disease	0.65
NEUTROPHIL	increases	cell_type	0.65
IL-6	inhibits	gene	0.65
LYMPHOMA	reduces	disease	0.65
TUMOR	inhibits	disease	0.60
MONOCYTE	promotes	cell_type	0.60
MONOCYTES	promotes	cell_type	0.60
T CELL	activates	cell_type	0.60
T CELLS	activates	cell_type	0.60
LYMPHOMA	inhibits	disease	0.60
GFAP	activates	gene	0.60
MACROPHAGE	regulates	cell_type	0.60
MACROPHAGES	regulates	cell_type	0.60
STING	causes	gene	0.60
MYC	activates	gene	0.60
CHAT	activates	gene	0.60
NEURON	activates	cell_type	0.60
NEURONS	activates	cell_type	0.60
SIRT6	co_discussed	entity	0.50
FOXO3	co_discussed	entity	0.50
IL6	co_discussed	entity	0.50
JAK	co_discussed	entity	0.50
SENESCENCE	co_discussed	entity	0.50
FOXP3	co_discussed	entity	0.50
Immunotherapy	activates	process	0.50
B CELLS	activates	concept	0.50
CGAS	co_discussed	entity	0.50
CASP1	co_discussed	entity	0.50
HISTONE	co_discussed	entity	0.50
BDNF	co_discussed	entity	0.50
Dna Damage Response	regulates	pathway	0.50
Microrna	interacts_with	pathway	0.50
Proteins	interacts_with	protein	0.50
B CELLS	interacts_with	concept	0.50
SIRT1	co_discussed	entity	0.50
B CELLS	expressed_in	concept	0.50
GENE EXPRESSION	expressed_in	concept	0.50
CSF1R	co_discussed	entity	0.50
CHOLESTEROL	co_discussed	entity	0.50
MLKL	co_discussed	entity	0.50
MTOR	co_discussed	entity	0.50

Incoming (410)

Source	Relation	Type	Str
Inebilizumab	downregulates	drug	0.90
AMPK	activates	gene	0.65
PER	expressed_in	gene	0.60
CD19	inhibits	gene	0.60
MTOR	activates	gene	0.60
RNA	biomarker_for	gene	0.60
CD19	associated_with	gene	0.60
EMD	activates	gene	0.60
EHMT2	inhibits	gene	0.60
AMPK	protects_against	gene	0.60
MAF	activates	gene	0.60
FOS	therapeutic_target	gene	0.60
CD19	biomarker_for	gene	0.60
PARKINSON	activates	gene	0.60
SYNAPSE	activates	gene	0.60
BAX	inhibits	gene	0.60
COMPLEMENT	inhibits	gene	0.60
JUN	transports	gene	0.60
CASPASE8	inhibits	gene	0.60
FOXO1	inhibits	gene	0.60
FOXO3	protects_against	gene	0.60
LC3B	protects_against	gene	0.60
IRF8	activates	gene	0.60
GLIOBLASTOMA	associated_with	gene	0.60
CD4	associated_with	gene	0.60
GJA1	therapeutic_target	gene	0.60
CCL2	therapeutic_target	gene	0.60
YY1	activates	gene	0.60
ASTROCYTE	activates	gene	0.60
ERK	activates	gene	0.60
GLAUCOMA	activates	gene	0.60
MAPK	activates	gene	0.60
AQP4	inhibits	gene	0.60
ASTROCYTE	therapeutic_target	gene	0.60
ASTROCYTES	therapeutic_target	gene	0.60
MAX	activates	gene	0.60
AQP4	activates	gene	0.60
FUT8	activates	gene	0.60
ST6GAL1	transports	gene	0.60
CASPASE3	inhibits	gene	0.60
APOPTOSIS	activates	gene	0.60
JUN	inhibits	gene	0.60
RNA	regulates	gene	0.60
SIRT1	protects_against	gene	0.60
OCLN	activates	gene	0.60
AUTOPHAGY	protects_against	gene	0.60
AKT	activates	gene	0.60
LDL	activates	gene	0.60
RNA	associated_with	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Aryl Hydrocarbon Receptor (AHR) Activation in B Cells Determ	0.683	neuroinflammation	How do B cells mechanistically orchestra

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
IL-10 deficiency and VLC ceramide accumulation in inflammatory bowel d	validation	inflammatory bowel disease	0.900	0.00	IL-10 knockout mice	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning B CELL in their description or question text

No additional research found