PE

What is the evidence that blood-brain barrier (BBB) permeability changes serve a

closed · Rounds: 4 · Score: 1.00 · 2026-04-26

Blood-brain barrier permeability changes as early biomarkers for neurodegenerati

closed · Rounds: 7 · Score: 0.50 · 2026-04-26

Thalamic anterior nucleus hyperconnectivity drives early-stage functional compen

Score: 0.000 · Alzheimer's disease · 2026-04-27

We hypothesize that in early Alzheimer's disease (CDR 0.5-1), the anterior thalamic nuclei develop functional hyperconne

Convergent NF-κB enhancers across diverse priming stimuli share therapeutic vuln

Score: 0.000 · Alzheimer's disease · 2026-04-26

Despite different initial triggers (LPS, β-amyloid, aging), primed microglia may converge on a common 'epigenetic primin

APOE4-driven loss of neuronal PI(4,5)P2 bridges ganglioside-mediated amyloid nuc

Score: 0.000 · Alzheimer disease · 2026-04-27

In APOE4 carriers, the composition of astrocyte-secreted APOE-containing lipid particles becomes enriched in ganglioside

AD Polygenic Risk Score predicts transcriptomic aging acceleration in a dose-dep

Score: 0.000 · unknown disease · 2026-04-27

Individuals with high AD polygenic risk score (PRS) show earlier onset and steeper progression of the mouse-defined tran

AD fine-mapping identifies causal variants in microglia-specific enhancers with

Score: 0.000 · Alzheimer's disease · 2026-04-26

Bayesian fine-mapping of the top 25 AD GWAS loci will identify credible sets significantly enriched for variants disrupt

O-GlcNAcylation at T212 competes with phosphorylation to redirect pathological t

Score: 0.000 · Alzheimer's disease and related tauopathies · 2026-04-26

We hypothesize that pathological tau's abnormal interaction with the ESCRT machinery for exosomal release is driven by s

ω-3 Docosahexaenoic Acid (DHA) Metabolism via 15-Lipoxygenase to Generate Specia

Score: 0.000 · lipidomics · 2026-04-26

This hypothesis proposes that 15-lipoxygenase (15-LOX) enzymatically converts docosahexaenoic acid (DHA) into specialize

Magnetofection-Enhanced IGFBPL1 Delivery via Superparamagnetic Iron Oxide Nanopa

Score: 0.000 · drug delivery · 2026-04-26

The molecular foundation of magnetofection-mediated IGFBPL1 delivery exploits superparamagnetic iron oxide nanoparticles

LRP1-Mediated Endosomal Escape Enhancement Strategy

Score: 0.000 · neuropharmacology · 2026-04-26

The LRP1-Mediated Endosomal Escape Enhancement Strategy proposes that therapeutic antibody delivery to the CNS can be op

Theta-Alpha Oscillation Entrainment Enhances lncRNA-9969-Mediated Mitochondrial

Score: 0.000 · molecular neurobiology · 2026-04-27

**Molecular Mechanism and Rationale** This therapeutic mechanism centers on a distinct circuit-RNA regulatory network th

Competitive endogenous RNA network modulates mmu-miR-6361 availability through l

Score: 0.000 · molecular neurobiology · 2026-04-27

The most likely explanation involves lncRNA-0021 functioning as a competitive endogenous RNA (ceRNA) that dynamically se

Aggregation-prone sequences trigger HSP90-dependent conformational triage throug

Score: 0.000 · protein biochemistry · 2026-04-26

The cellular response to amyloidogenic protein species involves a sophisticated HSP90-dependent conformational triage sy

TREM2-Dependent Astrocyte-Microglia Cross-talk in Neuroinflammation

Score: 0.000 · neurodegeneration · 2026-04-27

TREM2-Dependent Astrocyte-Microglia Cross-talk in Neuroinflammation proposes that TREM2 dysfunction disrupts critical in

LDLR-Primed LRP1 Transcytosis with pH-Activated Endosomal Escape

Score: 0.000 · neuropharmacology · 2026-04-27

This strategy combines LDLR upregulation in brain endothelial cells with engineered LRP1-targeting antibodies containing

Autophagy-Lysosomal Clearance Capacity Determines Therapeutic Window—Substrate C

Score: 0.000 · protein folding · 2026-04-27

**Molecular Mechanism and Rationale** This therapeutic hypothesis targets the autophagy-lysosomal degradation pathway's