gene 1,330 words KG: ent-gene-d18ffdc5
Contents

ATG12 — Autophagy Related 12

🧬 Gene Info
Gene SymbolATG12
Full NameAutophagy Related 12
Chromosome5q21.2
Protein FamilyATG12 family
Functionis a ubiquitin-like protein that plays an essential role in autophagy, the cellular process for degrading and recycling damaged organelles and proteins.
Subcellular LocalizationCytoplasm, autophagosome membrane
Molecular Weight~15 kDa
PathwaysAutophagy, Cell Cycle, Mitophagy
UniProt IDO95166
NCBI Gene ID9459
Ensembl IDENSG00000181458
GeneCardsATG12
Human Protein AtlasATG12
Associated DiseasesAls, Alzheimer, Ataxia, Infection, Ms, Neurodegeneration
Known Drugs/Compoundsrapamycin
InteractionsACTB, AGING, AKT, ALS, ALZHEIMER, AMPK
KG Connections459 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (17)

Transcriptional Autophagy-Lysosome Coupling
Score: 0.76
FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63
APOE-Dependent Autophagy Restoration
Score: 0.88
Phase-Separated Organelle Targeting
Score: 0.73
Stress Granule Phase Separation Modulators
Score: 0.72
Autophagosome Maturation Checkpoint Control
Score: 0.71
Lysosomal Calcium Channel Modulation Therapy
Score: 0.70
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Cross-Seeding Prevention Strategy
Score: 0.69
Lysosomal Positioning Dynamics Modulation
Score: 0.69
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67
RNA Granule Nucleation Site Modulation
Score: 0.66
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
Score: 0.62
Cryptic Exon Silencing Restoration
Score: 0.53

Related Analyses (7)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived

Related Experiments (3)

Autophagy Enhancement Drug Screening for Neurodegeneration
clinical · proposed · Score: 0.40
Gene expression analysis of autophagy targets following treh
exploratory · proposed · Score: 0.85
Trehalose-induced autophagy gene expression analysis
exploratory · proposed · Score: 0.85

See Also (12)

Amyotrophic Lateral Sclerosis
redirect · KG edge: activates
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: activates
ARAF Gene
gene · KG edge: activates
ATF4 Gene
gene · KG edge: regulates

Knowledge Graph (2 edges)

ent-gene-d18ffdc5 data_in benchmark_ot_ad_answer_key:ATG12
benchmark_ot_ad_answer_key:ATG12 data_in ent-gene-d18ffdc5

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