protein 579 words KG: ATG12
Contents

ATG12 Protein

🔬 Protein Info
Gene SymbolATG12
Chromosome5q21.2
Protein FamilyATG12 family
Functionis a ubiquitin-like protein that plays an essential role in autophagy, the cellular process for degrading and recycling damaged organelles and proteins.
Subcellular LocalizationCytoplasm, autophagosome membrane
Molecular Weight~15 kDa
PathwaysAutophagy, Cell Cycle, Mitophagy
UniProt IDO95166
NCBI Gene ID9459
Ensembl IDENSG00000181458
GeneCardsATG12
Human Protein AtlasATG12
Associated DiseasesAls, Alzheimer, Ataxia, Infection, Ms, Neurodegeneration
Known Drugs/Compoundsrapamycin
InteractionsACTB, AGING, AKT, ALS, ALZHEIMER, AMPK
KG Connections463 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (16)

Digital Twin-Guided Metabolic Reprogramming
Score: 0.55
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.91
Transcriptional Autophagy-Lysosome Coupling
Score: 0.88
Autophagosome Maturation Checkpoint Control
Score: 0.71
Lysosomal Calcium Channel Modulation Therapy
Score: 0.70

Related Analyses (8)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Autophagy Enhancement Drug Screening for Neurodegeneration
clinical · proposed · Score: 0.40

See Also (7)

Amyotrophic Lateral Sclerosis
redirect · KG edge: activates
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Apoptosis in Neurodegeneration
entity · KG edge: activates
ARAF Gene
gene · KG edge: activates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: associated_with

Knowledge Graph (12 edges)

STIP1 activates ATG12
LGALS3 activates ATG12
HSPA8 activates ATG12
MCOLN1 activates ATG12
SQSTM1 activates ATG12
SOD1 activates ATG12
BCL2 activates ATG12
CTSB activates ATG12
TPP1 activates ATG12
GLA activates ATG12

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