gene

GSK3A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GSK3A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

27Connections

0Hypotheses

0Analyses

20Outgoing

7Incoming

0Experiments

0Debates

Summary

GSK3A is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, implicated in. Associated with Alzheimer. Connected to 21 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	GSK3A
Full Name	Glycogen Synthase Kinase 3 Alpha
Chromosome	19q13.2
Protein Type	Kinase
Function	GSK3A encodes a serine/threonine-protein kinase that is constitutively active in neurons.
Molecular Weight	52.9 kDa
Pathways	NF-κB, Wnt, PI3K, MAPK
UniProt ID	GSK3A
NCBI Gene ID	2931
Ensembl ID	ENSG00000105723
OMIM	604489
GeneCards	GSK3A
Human Protein Atlas	GSK3A
Associated Diseases	neurodegeneration
Interactions	ALZHEIMER, ALZHEIMER'S DISEASE, APOPTOSIS, APP, APP/PS1, MICROGLIA
KG Connections	27 knowledge graph edges
Databases	GeneCards HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

GSK3A Gene

gene · 695 words

→

GSK3A Protein

protein · 698 words

→

Pathway Diagram

graph TD
    GSK3A["GSK3A"]
    Alzheimer{"Alzheimer"}
    GSK3A -->|"activates"| Alzheimer
    APP_PS1["APP/PS1"]
    GSK3A -->|"activates"| APP_PS1
    MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"]
    GSK3A -->|"activates"| MITOCHONDRIAL_DYSFUNCTION
    APP["APP"]
    GSK3A -->|"activates"| APP
    APOPTOSIS["APOPTOSIS"]
    GSK3A -->|"activates"| APOPTOSIS
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    GSK3A -->|"activates"| OXIDATIVE_STRESS
    Apoptosis(["Apoptosis"])
    GSK3A -->|"activates"| Apoptosis
    Wnt(["Wnt"])
    GSK3A -->|"regulates"| Wnt
    Neurogenesis(["Neurogenesis"])
    GSK3A -->|"activates"| Neurogenesis
    Oxidative_Stress(["Oxidative Stress"])
    GSK3A -->|"activates"| Oxidative_Stress
    neurodegeneration["neurodegeneration"]
    GSK3A -->|"implicated in"| neurodegeneration
    MICROGLIA["MICROGLIA"]
    MICROGLIA -->|"activates"| GSK3A
    SIRT3["SIRT3"]
    SIRT3 -->|"activates"| GSK3A
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"activates"| GSK3A
    style GSK3A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (20)

Target	Relation	Type	Str
Alzheimer	activates	disease	0.65
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
Apoptosis	activates	pathway	0.60
Wnt	regulates	pathway	0.60
Neurogenesis	activates	pathway	0.60
APP/PS1	activates	gene	0.60
Oxidative Stress	activates	pathway	0.60
MICROGLIA	activates	gene	0.60
Differentiation	regulates	pathway	0.60
Stem Cell	activates	pathway	0.60
SIRT3	activates	gene	0.60
GSK3B	associated_with	gene	0.60
Wnt signaling	participates_in	pathway	0.60
APP	activates	gene	0.60
Neural Stem Cell	expressed_in	cell_type	0.55
Stem Cell	expressed_in	cell_type	0.55
Neuron	expressed_in	cell_type	0.55
Microglia	expressed_in	cell_type	0.55

Incoming (7)

Source	Relation	Type	Str
SIRT3	activates	gene	0.60
MICROGLIA	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
APP/PS1	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
ALZHEIMER	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GSK3A in their description or question text

No additional research found