gene

ABCA2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ABCA2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

113Connections

0Hypotheses

0Analyses

50Outgoing

48Incoming

0Experiments

0Debates

Summary

A gene referenced in 100 knowledge graph relationships. Key connections: expressed_in Cancer (disease); expressed_in Carcinoma (disease); regulates Alzheimer (disease).

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🧬 Gene Info

Gene Symbol	ABCA2
Aliases	Page for ABCA2 Gene
Chromosome	9q34.3 (human)
Protein Family	ABC transporter family, subfamily A
Protein Type	Transporter
Function	encodes a member of the ATP-binding cassette transporter family, predominantly expressed in the brain.
Molecular Weight	270 kDa
Amino Acids	2436 aa
Pathways	Cholesterol
UniProt ID	Q9BZC7
NCBI Gene ID	20
GeneCards	ABCA2
Human Protein Atlas	ABCA2
Associated Diseases	Alzheimer's disease risk, Neurodegeneration
Interactions	ABCA1, APOA1, APOC1, APOC2, APOC3, APOD
KG Connections	101 knowledge graph edges
Databases	GeneCards HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

ABCA2 Gene - ATP Binding Cassette Subfamily A Member 2

gene · 1622 words

→

ABCA2 Protein

protein · 648 words

→

Pathway Diagram

flowchart TD
    A["ABCA2"] --> B["Cholesterol Efflux"]
    A --> C["Lipid Homeostasis"]
    A --> D["LDL Uptake"]
    B --> E["Neuronal Membrane Fluidity"]
    C --> F["Amyloid-Beta Clearance"]
    D --> C
    E --> G["Neuroprotection"]
    F --> G
    C --> H["Cognitive Function"]
    F --> I["Oxidative Stress"]
    I --> G

Outgoing (65)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:ABCA2	data_in	dataset_row	0.00
ALS	transports	disease	0.65
Atherosclerosis	transports	disease	0.65
Alzheimer	transports	disease	0.65
Als	degrades	disease	0.65
Alzheimer	degrades	disease	0.65
Atherosclerosis	degrades	disease	0.65
Alzheimer	regulates	disease	0.65
Als	regulates	disease	0.65
Atherosclerosis	regulates	disease	0.65
Cancer	expressed_in	disease	0.65
Carcinoma	expressed_in	disease	0.65
TAU	transports	gene	0.60
APOC1	transports	gene	0.60
LRP1	transports	gene	0.60
SREBF1	transports	gene	0.60
APOC3	transports	gene	0.60
APOC2	transports	gene	0.60
GSK3B	degrades	gene	0.60
TAU	degrades	gene	0.60
LIPA	degrades	gene	0.60
APOA1	activates	gene	0.60
APOC1	activates	gene	0.60
APOC2	activates	gene	0.60
APOE	activates	gene	0.60
CYP46A1	activates	gene	0.60
LRP1	activates	gene	0.60
LRP8	activates	gene	0.60
SOAT1	activates	gene	0.60
CANCER	expressed_in	gene	0.60
Cholesterol	activates	pathway	0.60
Neuron	activates	cell_type	0.60
PSEN2	regulates	gene	0.60
TAU	regulates	gene	0.60
LDLR	activates	gene	0.60
APOC3	activates	gene	0.60
PSEN1	transports	gene	0.60
ALZHEIMER'S DISEASE	transports	gene	0.60
AND	transports	gene	0.60
App	degrades	protein	0.60
APOD	activates	gene	0.60
TFCP2	degrades	gene	0.60
CH25H	transports	gene	0.60
APOD	transports	gene	0.60
GENES	transports	gene	0.60
ALZHEIMER	transports	gene	0.60
CH25H	activates	gene	0.60
lipid metabolism	participates_in	pathway	0.60
neurons	expressed_in	cell_type	0.60
ATP7A	expressed_in	gene	0.60

Incoming (48)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:ABCA2	data_in	dataset_row	0.00
genes-abca2	describes	wiki_page	0.95
MAPT	regulates	gene	0.60
LRP1	activates	gene	0.60
LIPA	regulates	gene	0.60
APP	regulates	gene	0.60
APOE	activates	gene	0.60
CYP46A1	activates	gene	0.60
ABCA1	activates	gene	0.60
NCSTN	regulates	gene	0.60
GSK3B	regulates	gene	0.60
PSEN1	regulates	gene	0.60
SREBF1	regulates	gene	0.60
APOC1	activates	gene	0.60
APOC2	activates	gene	0.60
SOAT1	activates	gene	0.60
APOE	transports	gene	0.60
NCSTN	transports	gene	0.60
PSEN2	transports	gene	0.60
LIPA	transports	gene	0.60
LDLR	transports	gene	0.60
ABCA1	transports	gene	0.60
GSK3B	transports	gene	0.60
LRP8	transports	gene	0.60
APOA1	transports	gene	0.60
CYP46A1	transports	gene	0.60
SOAT1	transports	gene	0.60
APP	transports	gene	0.60
MAPT	transports	gene	0.60
APOC3	activates	gene	0.60
APP	degrades	gene	0.60
PSEN2	degrades	gene	0.60
MAPT	degrades	gene	0.60
SREBF1	degrades	gene	0.60
NCSTN	degrades	gene	0.60
PSEN1	degrades	gene	0.60
LRP8	activates	gene	0.60
ALZHEIMER	regulates	gene	0.60
APOD	activates	gene	0.60
TFCP2	regulates	gene	0.60
LDLR	activates	gene	0.60
APOA1	activates	gene	0.60
CH25H	activates	gene	0.60
ALZHEIMER	degrades	gene	0.60
TFCP2	transports	gene	0.60
ABCD3	expressed_in	gene	0.60
APOE	activates	gene	0.50
ABCA1	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ABCA2 in their description or question text

No additional research found