gene 879 words KG: ent-gene-3f9d72d2
Contents

AKT3 Gene

🧬 Gene Info
Gene SymbolAKT3
Full NameAKT Serine/Threonine Kinase 3
AliasesPKB-gamma, RAC-gamma
Chromosome1q43-q44
Protein TypeKinase
FunctionSerine/threonine kinase regulating brain development and neuronal survival
Primary Expressionsubstantia nigra dopaminergic neurons
Molecular Weight55.8 kDa
Amino Acids479
PathwaysPI3K-AKT signaling, mTOR pathway
UniProt IDQ9Y243
NCBI Gene ID10000
Ensembl IDENSG00000117020
OMIM611495
GeneCardsAKT3
Human Protein AtlasAKT3
Associated DiseasesAging, Als, Atherosclerosis, Cancer, Cardiovascular
InteractionsAkt, APOPTOSIS, APP, BRAF, CASP1, CDKN2A
KG Connections161 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (7)

APOE-Dependent Autophagy Restoration
Score: 0.88
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
CYP46A1 Overexpression Gene Therapy
Score: 0.73
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
KDM6A-Mediated H3K27me3 Rejuvenation
Score: 0.65

Related Analyses (5)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (5)

AKT1 Gene
gene · KG edge: associated_with
AKT2 Gene
gene · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: therapeutic_target
Packard Center for ALS Research
institution · KG edge: associated_with
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with

Knowledge Graph (4 edges)

22729224 has mutations in ent-gene-3f9d72d2
22729224 has de novo mutations in ent-gene-3f9d72d2
ent-gene-3f9d72d2 data_in benchmark_ot_ad_answer_key:AKT3
benchmark_ot_ad_answer_key:AKT3 data_in ent-gene-3f9d72d2

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