gene 2,958 words KG: AKT2
Contents

AKT2 Gene

🧬 Gene Info
Gene SymbolAKT2
Full NameAKT Serine/Threonine Kinase 2
Chromosome19q13.2
Protein TypeKinase
Functionis a crucial signaling molecule in the PI3K/AKT signaling pathway that plays essential roles in cell survival, metabolism, and neuronal function.
Primary ExpressionBrain (widespread), Muscle, Liver, Adipose tissue
Exons13
PathwaysAkt, Apoptosis, Autophagy, Immune Response, Mitophagy
UniProt IDP31751
NCBI Gene ID207
Ensembl IDENSG00000105221
OMIM164731
GeneCardsAKT2
Human Protein AtlasAKT2
Associated DiseasesAging, Als, Atherosclerosis, Cancer, Cardiovascular
InteractionsALZHEIMER, ALZHEIMER'S DISEASE, AND, APOPTOSIS, APP, APP/PS1
KG Connections97 knowledge graph edges
DatabasesGeneCardsHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (8)

Transcriptional Autophagy-Lysosome Coupling
Score: 0.88
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65
TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
Score: 0.62
CYP46A1 Overexpression Gene Therapy
Score: 0.92
APOE-Dependent Autophagy Restoration
Score: 0.85

Related Analyses (4)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (9)

Apoptosis in Neurodegeneration
entity · KG edge: regulates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
AKT1 Gene
gene · KG edge: associated_with
AKT3 Gene
gene · KG edge: associated_with
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: activates

Knowledge Graph (12 edges)

AKT3 associated_with AKT2
AKT associated_with AKT2
PI3K regulates AKT2
MTOR regulates AKT2
AKT2 associated_with AKT1
CFH activates AKT2
AKT2 activates TFE3
AKT2 activates TFEB
AKT2 activates UBIQUITIN
AKT2 regulates MUL1

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