gene

aplp2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about aplp2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

39Connections

0Hypotheses

0Analyses

34Outgoing

5Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	APLP2
Full Name	Amyloid Beta Precursor-Like Protein 2
Aliases	Amyloid Precursor-Like Protein 2
Chromosome	15q24.2
Function	encodes a protein of approximately 763 amino acids.
Primary Expression	neurons, astrocytes, oligodendrocytes, and microglia, with regional distribution in cerebral cortex, hippocampus, cerebellum, thalamus, and hypothalam
Molecular Weight	87 kDa
Amino Acids	763 aa
UniProt ID	[Q06481](https://www.uniprot.org/uniprot/Q06481)
Ensembl ID	ENSG00000145087
GeneCards	APLP2
Human Protein Atlas	APLP2
Associated Diseases	Alzheimer's disease, Parkinson's disease
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

APLP2 Gene

gene · 797 words

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Pathway Diagram

graph TD
    APLP2["APLP2"]
    APLP2 -.protects against.-> Als["Als"]
    APLP2 -->|"activates"| Aging["Aging"]
    APLP2 -->|"regulates"| Alzheimer["Alzheimer"]
    APLP2 -->|"regulates"| Ms["Ms"]
    APLP2 -->|"contributes to"| Cancer["Cancer"]
    AGING["AGING"] -->|"activates"| APLP2

Outgoing (34)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:APLP2	data_in	dataset_row	0.00
Synaptic Plasticity	regulates	process	0.90
APP	associated_with	gene	0.70
Ms	regulates	disease	0.65
Als	protects_against	disease	0.65
Alzheimer	contributes_to	disease	0.65
Alzheimer	regulates	disease	0.65
Alzheimer	interacts_with	disease	0.65
Cancer	contributes_to	disease	0.65
Als	associated_with	disease	0.65
Aging	activates	disease	0.65
Als	interacts_with	disease	0.65
ALZHEIMER'S DISEASE	contributes_to	gene	0.60
synaptic plasticity	participates_in	pathway	0.60
APLP1	protects_against	gene	0.60
AKT	activates	gene	0.60
APP	protects_against	gene	0.60
ADAM10	activates	gene	0.60
APLP1	regulates	gene	0.60
NPAS4	regulates	gene	0.60
APP	regulates	gene	0.60
AMYLOID	associated_with	gene	0.60
APP	activates	gene	0.60
Akt	activates	pathway	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
Notch	regulates	pathway	0.60
ALZHEIMER'S DISEASE	interacts_with	gene	0.60
APOPTOSIS	interacts_with	gene	0.60
Apoptosis	interacts_with	pathway	0.60
ALZHEIMER	contributes_to	gene	0.60
APP	targets	gene	0.60
CANCER	contributes_to	gene	0.60
APLP1	associated_with	gene	0.60
neurons	expressed_in	cell_type	0.55

Incoming (5)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:APLP2	data_in	dataset_row	0.00
APP	interacts_with	protein	0.85
APLP1	targets	gene	0.60
AGING	activates	gene	0.60
APLP1	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning aplp2 in their description or question text

No additional research found