gene 1,696 words KG: ADAM10
Contents

ADAM10 — A Disintegrin And Metalloproteinase Domain 10

🧬 Gene Info
Gene SymbolADAM10
Full NameA Disintegrin And Metalloproteinase Domain 10
AliasesKuzbanian, CD156c
Chromosome15q21.3
FunctionAlpha-secretase, cleaves APP via non-amyloidogenic pathway
Molecular Weight84.1 kDa
Amino Acids748
PathwaysNon-amyloidogenic APP processing, Notch signaling
UniProt IDO14672
NCBI Gene ID102
Ensembl IDENSG00000137845
OMIM602192
GeneCardsADAM10
Human Protein AtlasADAM10
Associated DiseasesAGING, Als, Alzheimer, Cancer, Dementia
InteractionsACAT1, AD, ADAM17, ADAMTS4, AGING, AKT
KG Connections453 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (30)

Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
TREM2-mediated microglial tau clearance enhancement
Score: 0.59
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76

Related Analyses (10)

TREM2 agonism vs antagonism in DAM microglia
neurodegeneration · completed
What is the temporal sequence of TREM2 signaling transition
neuroimmunology · completed
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

Microglial Aging and Immune Memory in Neurodegeneration — Tr
validation · proposed · Score: 0.40
Experiment Validation: In vitro ThT Assay
validation · proposed · Score: 0.40

See Also (6)

ABCA7 (Redirect)
redirect · KG edge: associated_with
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: co_discussed
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: activates

Knowledge Graph (12 edges)

TREM2 inhibits ADAM10
ADAM10 regulates Notch pathway
CAPN1 therapeutic_target ADAM10
TTR therapeutic_target ADAM10
LGALS3 therapeutic_target ADAM10
CTSD therapeutic_target ADAM10
GRB2 therapeutic_target ADAM10
TLR4 therapeutic_target ADAM10
NFE2L2 therapeutic_target ADAM10
RPS6KA1 therapeutic_target ADAM10

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