concept

PD-L1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PD-L1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

379Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

No summary available yet.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	PD-L1
Key Genes/Proteins	Akt, APOB, APOPTOSIS, App, ARG1, ATM
Related Diseases	Aging, Als, ALS
Related Pathways	Apoptosis, autophagy, Autophagy

Wiki Pages (1)

Knowledge base pages for this entity

PD-1/PD-L1 Immune Checkpoint Signaling in Neurodegeneration

mechanism · 3120 words

→

Pathway Diagram

graph TD
    PD_L1["PD-L1"]
    PD_L1 -->|"promotes"| IL_6["IL-6"]
    PD_L1 -->|"inhibits"| T_Cell_Activity["T Cell Activity"]
    PD_L1 -->|"activates"| Jak2_Stat3_signaling["Jak2/Stat3 signaling"]
    PD_L1 -->|"binds"| PD_1["PD-1"]
    PD_L1 -->|"inhibits"| T_cells["T cells"]
    PD_L1 -->|"promotes"| oral_squamous_cell_carcinoma["oral squamous cell carcinoma"]
    PD_L1 -->|"inhibits"| PTPN1["PTPN1"]
    PD_L1 -->|"inhibits"| T_cell_function["T-cell function"]
    PER2["PER2"] -->|"inhibits"| PD_L1
    PINK1["PINK1"] -->|"recruits_to_mitochondria"| PD_L1
    OMA1["OMA1"] -->|"upregulates"| PD_L1
    PD_1 -->|"inhibits"| PD_L1
    TCe6_Cu_TP5_NPs["TCe6@Cu/TP5 NPs"] -->|"downregulates"| PD_L1
    NF__B["NF-kappaB"] -->|"activates"| PD_L1
    SMARCAL1["SMARCAL1"] -->|"promotes"| PD_L1
    Atezolizumab["Atezolizumab"] -->|"targets"| PD_L1

Outgoing (222)

Target	Relation	Type	Str
T Cell Activity	inhibits	process	0.95
IL-6	promotes	protein	0.95
Jak2/Stat3 signaling	activates	pathway	0.93
oral squamous cell carcinoma	promotes	disease	0.90
PTPN1	inhibits	protein	0.90
T-cell function	inhibits	process	0.90
T cells	inhibits	cell_type	0.90
Immunotherapy	regulates	process	0.90
STAT3	binds_to	protein	0.89
Cancer Cell Proliferation	involved_in	process	0.85
T Cell Cytotoxicity	inhibits	process	0.85
Systemic Immune Suppression	mediates	process	0.80
Glioblastoma	activates	disease	0.65
Als	activates	disease	0.65
Als	expressed_in	disease	0.65
Cancer	biomarker_for	disease	0.65
Aging	therapeutic_target	disease	0.65
Cancer	inhibits	disease	0.65
ALS	inhibits	disease	0.65
Tumor	expressed_in	disease	0.65
ALS	expressed_in	disease	0.65
Inflammation	activates	disease	0.65
Carcinoma	biomarker_for	disease	0.65
ALS	activates	disease	0.65
Carcinoma	inhibits	disease	0.65
Cancer	degrades	disease	0.65
Tumor	degrades	disease	0.65
Glioblastoma	inhibits	disease	0.65
Cancer	associated_with	disease	0.65
Cancer	therapeutic_target	disease	0.65
Tumor	inhibits	disease	0.65
Tumor	activates	disease	0.65
Cancer	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Carcinoma	activates	disease	0.65
Multiple Sclerosis	expressed_in	disease	0.65
Glioblastoma	therapeutic_target	disease	0.65
CGAS-STING	therapeutic_target	gene	0.60
Rb	expressed_in	protein	0.60
FASN	activates	gene	0.60
Lipid Metabolism	activates	pathway	0.60
Cholesterol	activates	pathway	0.60
Epithelial	activates	cell_type	0.60
CGAS	activates	gene	0.60
GBM	activates	gene	0.60
SQSTM1	inhibits	gene	0.60
LYSOSOME	inhibits	gene	0.60
HBA1	activates	gene	0.60
GLIOBLASTOMA	therapeutic_target	gene	0.60
Neutrophil	activates	cell_type	0.60

Incoming (157)

Source	Relation	Type	Str
PER2	inhibits	gene	0.95
PD-1	inhibits	gene	0.95
OMA1	upregulates	protein	0.95
PINK1	recruits_to_mitochondria	protein	0.95
NAD+ depletion	upregulates	mechanism	0.95
NF-κB	activates	pathway	0.90
SMARCAL1	promotes	gene	0.90
cGAS-STING Pathway	upregulates	pathway	0.90
Atezolizumab	targets	drug	0.90
Durvalumab	targets	drug	0.90
Avelumab	targets	drug	0.90
TCe6@Cu/TP5 NPs	downregulates	compound	0.90
type I interferon	associated_with	protein	0.90
STING1	associated_with	protein	0.90
autophagy	mediates	pathway	0.85
NUPR1	upregulates	gene	0.85
JUN	interacts_with	protein	0.85
brain metastases	associated_with	disease	0.70
PD-1	activates	gene	0.65
CD8	inhibits	gene	0.60
ERBB2	activates	gene	0.60
SF3B1	therapeutic_target	gene	0.60
RNA	therapeutic_target	gene	0.60
EEF1A1	therapeutic_target	gene	0.60
JUN	therapeutic_target	gene	0.60
P53	therapeutic_target	gene	0.60
IDH1	therapeutic_target	gene	0.60
SMARCA4	therapeutic_target	gene	0.60
TERT	therapeutic_target	gene	0.60
APOB	therapeutic_target	gene	0.60
MS4A4A	associated_with	gene	0.60
CCR8	associated_with	gene	0.60
LAG3	associated_with	gene	0.60
COMPLEMENT	associated_with	gene	0.60
TGFB1	associated_with	gene	0.60
KRAS	associated_with	gene	0.60
HEDGEHOG	associated_with	gene	0.60
NOTCH	associated_with	gene	0.60
CD163	associated_with	gene	0.60
STAT5B	associated_with	gene	0.60
PFKFB3	associated_with	gene	0.60
HDAC	inhibits	gene	0.60
LYSOSOME	activates	gene	0.60
CD8	activates	gene	0.60
CCL2	inhibits	gene	0.60
HER2	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
HSPA9	associated_with	gene	0.60
CGAS-STING	therapeutic_target	gene	0.60
CD68	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PD-L1 in their description or question text

No additional research found