protein

LAG3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LAG3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

121Connections

0Hypotheses

0Analyses

50Outgoing

23Incoming

0Experiments

0Debates

Summary

Page for LAG3 Protein (CD223)

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🔬 Protein Info

Gene Symbol	LAG3
Aliases	CD223
Protein Type	Receptor
Function	LAG3 is primarily expressed on activated T cells, regulatory T cells (Tregs), natural killer cells, and to a lesser extent on B cells and dendritic cells.
Molecular Weight	57 kDa
Pathways	Alpha-Synuclein Transmission
UniProt ID	[P18627](https://www.uniprot.org/uniprotkb/P18627)
GeneCards	LAG3
Human Protein Atlas	LAG3
Extracellular domain	Contains four immunoglobulin-like (Ig-like) domains (D1-D4) with structural homology to CD4
Transmembrane domain	Anchors the protein to the plasma membrane
Cytoplasmic tail	Contains a unique "KIEELE" motif essential for inhibitory signaling[@workman2014]
Associated Diseases	Cancer, MICROGLIAL ACTIVATION, Parkinson's Disease
Interactions	Akt, AKT, alpha-synuclein, ALZHEIMER, AMYLOID, AND
KG Connections	121 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

LAG3 Protein (CD223)

protein · 872 words

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Pathway Diagram

graph TD
    LAG3(["LAG3"])
    alpha_synuclein["alpha-synuclein"]
    Co_inhibitory_Gene_Module["Co-inhibitory Gene Module"]
    APLP1["APLP1"]
    Alpha_Synuclein["Alpha-Synuclein"]
    Alpha_Synuclein_Transmission["Alpha-Synuclein Transmission"]
    Neurodegeneration["Neurodegeneration"]
    Parkinson["Parkinson"]
    PARKINSON["PARKINSON"]
    Dopaminergic["Dopaminergic"]
    Neuron["Neuron"]
    FOXP3["FOXP3"]
    RNA["RNA"]
    PI3K["PI3K"]
    RICTOR["RICTOR"]
    AMYLOID["AMYLOID"]
    LDHA["LDHA"]
    MYC["MYC"]
    neurodegeneration["neurodegeneration"]
    LAG3 <-->|"interacts"| alpha_synuclein
    LAG3 -->|"component_of"| Co_inhibitory_Gene_Module
    APLP1 <-->|"interacts"| LAG3
    LAG3 -->|"binds"| Alpha_Synuclein
    LAG3 -->|"involved in"| Alpha_Synuclein_Transmission
    LAG3 -->|"activates"| Neurodegeneration
    LAG3 -->|"therapeutic_tar"| Parkinson
    LAG3 -->|"therapeutic_tar"| PARKINSON
    LAG3 <-->|"interacts"| APLP1
    LAG3 -->|"activates"| Dopaminergic
    LAG3 -->|"activates"| Neuron
    LAG3 -.->|"inhibits"| FOXP3
    LAG3 -.-|"associated"| RNA
    LAG3 -.->|"inhibits"| PI3K
    LAG3 -.->|"inhibits"| RICTOR
    AMYLOID <-->|"interacts"| LAG3
    LDHA -.->|"inhibits"| LAG3
    MYC -.->|"inhibits"| LAG3
    LAG3 -->|"implicated_in"| neurodegeneration
    style LAG3 fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (98)

Target	Relation	Type	Str
SNCA	binds	protein	0.95
alpha-synuclein	interacts_with	protein	0.95
microglial activation	mediates	process	0.92
Parkinson's Disease	therapeutic_target	disease	0.91
Alpha-Synuclein Transmission	involved_in	process	0.90
neuroinflammation	drives	process	0.90
A1 astrocyte	associated_with	cell_type	0.90
Alpha-Synuclein Internalization	mediates	process	0.90
microglia	expressed_in	cell_type	0.90
Alpha-Synuclein	binds	protein	0.90
Parkinson's Disease	implicated_in	disease	0.90
α-synuclein	facilitates_transmission_of	protein	0.90
alpha-synuclein	facilitates	protein	0.90
Parkinson'S Disease	therapeutic_target	disease	0.90
proinflammatory cytokines	upregulates	pathway	0.89
substantia nigra dopaminergic neurons	protects_against	cell_type	0.86
α-synucleinopathy	therapeutic_target	disease	0.85
α-synuclein pathology	suppresses	phenotype	0.85
co-inhibitory gene module	expressed_in	pathway	0.85
dopaminergic neuron	suppresses	cell_type	0.85
proinflammatory cytokine	associated_with	process	0.85
Dopaminergic Neurodegeneration	contributes_to	phenotype	0.85
microgliosis	suppresses	process	0.84
PI3K-Akt-Rictor pathway	inhibits	pathway	0.80
PI3K-Akt-Rictor	inhibits	pathway	0.70
LACTATE	inhibits	phenotype	0.65
NEURODEGENERATION	protects_against	phenotype	0.65
NEURODEGENERATION	inhibits	phenotype	0.65
NEURODEGENERATION	targets	phenotype	0.65
Alzheimer	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Parkinson	therapeutic_target	disease	0.65
MYC	interacts_with	gene	0.65
MICROGLIAL ACTIVATION	causes	phenotype	0.65
ASTROCYTES	activates	cell_type	0.65
ASTROCYTES	causes	cell_type	0.65
GLIOSIS	regulates	phenotype	0.65
Parkinson	activates	disease	0.65
MICROGLIA	regulates	cell_type	0.65
Cancer	associated_with	disease	0.65
KRAS	associated_with	gene	0.60
HEDGEHOG	associated_with	gene	0.60
NOTCH	associated_with	gene	0.60
PFKFB3	associated_with	gene	0.60
PD-L1	associated_with	gene	0.60
Nf-Κb	associated_with	pathway	0.60
Pi3K/Akt	associated_with	pathway	0.60
Mtor	associated_with	pathway	0.60
T Cell	associated_with	cell_type	0.60
Epithelial	associated_with	cell_type	0.60

Incoming (23)

Source	Relation	Type	Str
APLP1	interacts_with	protein	0.95
microglia	expressed_in	cell_type	0.94
SNCA	interacts_with	protein	0.93
AKT	activates	gene	0.65
NEURODEGENERATION	activates	gene	0.60
PARKINSON	activates	gene	0.60
TAU	inhibits	gene	0.60
AKT	inhibits	gene	0.60
FOXP3	inhibits	gene	0.60
MS4A4A	associated_with	gene	0.60
CCR8	associated_with	gene	0.60
LDHA	inhibits	gene	0.60
GENES	associated_with	gene	0.60
AMYLOID	interacts_with	gene	0.60
MYC	inhibits	gene	0.60
RICTOR	activates	gene	0.50
aplp1	activates	gene	0.50
aplp1	interacts_with	gene	0.50
Neurodegeneration	activates	disease	0.50
SUBSTANTIA NIGRA	associated_with	brain_region	0.50
Pi3K	activates	pathway	0.50
PARKINSON'S DISEASE	associated_with	disease	0.45
PARKINSON	associated_with	disease	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning LAG3 in their description or question text

No additional research found