concept

GSH

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GSH: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

838Connections

2Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

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💡 Concept Info

Name	GSH
Key Genes/Proteins	ACHE, ACSL4, ACTB, Actin, Akt, AKT
Related Diseases	Aging, Als, ALS, Alzheimer
Linked Hypotheses	2 hypotheses

Wiki Pages (1)

Knowledge base pages for this entity

SGSH Gene

gene · 606 words

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Pathway Diagram

graph TD
    GSH["GSH"]
    GSH -->|"activates"| GPX4["GPX4"]
    GSH -->|"involved_in"| Redox_Homeostasis["Redox Homeostasis"]
    GSH -->|"expressed in"| Retinal_Ganglion_Cell["Retinal Ganglion Cell"]
    GSH -->|"activates"| ROS["ROS"]
    GSH -->|"inhibits"| NEURON["NEURON"]
    GSH -->|"activates"| SLC7A11["SLC7A11"]
    GSH -->|"activates"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    FERROPTOSIS["FERROPTOSIS"] -->|"activates"| GSH
    NRF2["NRF2"] -->|"regulates"| GSH
    APOPTOSIS["APOPTOSIS"] -->|"activates"| GSH
    GPX4 -->|"inhibits"| GSH
    CATALASE["CATALASE"] -->|"interacts"| GSH
    GLIOSIS["GLIOSIS"] -->|"activates"| GSH
    ACSL4["ACSL4"] -->|"activates"| GSH

Outgoing (510)

Target	Relation	Type	Str
GSH	encodes	protein	0.00
oxidative stress response	participates_in	pathway	0.90
GPX4	activates	protein	0.90
ferroptosis	participates_in	pathway	0.90
neurons	expressed_in	cell_type	0.80
ROS	inhibits	gene	0.80
unfolded protein response	participates_in	pathway	0.80
ferroptosis	activates	process	0.80
Retinal Ganglion Cell	expressed_in	cell_type	0.75
neurons	regulates	cell_type	0.70
neurons	activates	cell_type	0.70
ferroptosis	protective_against	mechanism	0.70
ferroptosis	prevents	mechanism	0.70
hippocampus	expressed_in	brain_region	0.70
apoptosis pathway	participates_in	pathway	0.70
pyroptosis	participates_in	pathway	0.70
Parkinson	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Als	protects_against	disease	0.65
Ferroptosis	associated_with	disease	0.65
ROS	activates	protein	0.65
Tumor	degrades	disease	0.65
Ischemia	inhibits	disease	0.65
Alzheimer	inhibits	disease	0.65
Hypertension	inhibits	disease	0.65
Glaucoma	causes	disease	0.65
Ischemia	activates	disease	0.65
Depression	inhibits	disease	0.65
ALS	regulates	disease	0.65
Als	inhibits	disease	0.65
Neuroinflammation	causes	disease	0.65
Neurodegeneration	causes	disease	0.65
Aging	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Diabetes	inhibits	disease	0.65
Inflammation	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Inflammation	causes	disease	0.65
Depression	regulates	disease	0.65
Pyroptosis	biomarker_for	disease	0.65
Ferroptosis	biomarker_for	disease	0.65
Huntington	activates	disease	0.65
Huntington	regulates	disease	0.65
Inflammation	activates	disease	0.65
Stroke	inhibits	disease	0.65
Aging	regulates	disease	0.65
Inflammation	inhibits	disease	0.65
ALS	activates	disease	0.65
Spinal Cord Injury	regulates	disease	0.65
Als	regulates	disease	0.65

Incoming (328)

Source	Relation	Type	Str
GSH	encodes	gene	0.00
NRF2	upregulates	protein	0.90
FERROPTOSIS	activates	process	0.80
CAT	associated_with	gene	0.80
ALOX12	expressed_in	gene	0.70
NRF2	regulates	protein	0.64
ATP	activates	gene	0.60
BAX	activates	gene	0.60
BCL2	activates	gene	0.60
BECN1	activates	gene	0.60
BNIP3	activates	gene	0.60
BNIP3L	activates	gene	0.60
CASP1	activates	gene	0.60
DNM1L	activates	gene	0.60
DRP1	activates	gene	0.60
FUNDC1	activates	gene	0.60
AMBRA1	inhibits	gene	0.60
BAX	inhibits	gene	0.60
BCL2	inhibits	gene	0.60
BECN1	inhibits	gene	0.60
BNIP3	inhibits	gene	0.60
BNIP3L	inhibits	gene	0.60
CASP1	inhibits	gene	0.60
CAT	inhibits	gene	0.60
DNM1L	inhibits	gene	0.60
DRP1	inhibits	gene	0.60
FUNDC1	inhibits	gene	0.60
CHOP	activates	gene	0.60
CREB	activates	gene	0.60
GFAP	activates	gene	0.60
BDNF	inhibits	gene	0.60
CHOP	inhibits	gene	0.60
CREB	inhibits	gene	0.60
GFAP	inhibits	gene	0.60
valproic acid	activates	compound	0.60
ACSL4	regulates	gene	0.60
GPX4	regulates	gene	0.60
valproic acid	regulates	compound	0.60
ACSL4	treats	gene	0.60
GPX4	treats	gene	0.60
valproic acid	treats	compound	0.60
valproic acid	inhibits	compound	0.60
CAT	regulates	gene	0.60
ACSL4	expressed_in	gene	0.60
GPX4	expressed_in	gene	0.60
metformin	targets	drug	0.60
GABA	associated_with	gene	0.60
GABA	activates	gene	0.60
CX43	biomarker_for	gene	0.60
GCLM	causes	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
SLC7A11 System Activation Restores Cystine Uptake and GSH Sy	0.812	neurodegeneration	View
N-acetylcysteine (NAC) / System Xc⁻ - Mediated GSH Support f	0.760	neurodegeneration	Can ferroptosis inhibitors prevent BBB d

Mentioning Analyses (1)

Scientific analyses that reference this entity

Can ferroptosis inhibitors prevent BBB disruption and edema formation after card

neurodegeneration | 2026-04-25 | 7 hypotheses Top: 0.760

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (5)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
Multiple Sclerosis Pathology. [PMID:29358320]	Lassmann H	Cold Spring Harbor perspective	2018

Debates (1)

Multi-agent debates referencing this entity

Can ferroptosis inhibitors prevent BBB disruption and edema formation after card

closed · Rounds: 4 · Score: 0.73 · 2026-04-25

Related Research

Hypotheses and analyses mentioning GSH in their description or question text

No additional research found