gene

SORCS2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SORCS2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

45Connections

0Hypotheses

0Analyses

28Outgoing

17Incoming

0Experiments

0Debates

Summary

Sortilin-related VPS10 domain-containing receptor 2 - a neuronal trafficking receptor implicated in Alzheimer's and Parkinson's disease risk

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🧬 Gene Info

Gene Symbol	SORCS2
Full Name	Sortilin-Related VPS10 Domain Containing Receptor 2
Aliases	Sortilin-related VPS10 domain-containing receptor 2
Chromosome	4p16.1
Protein Type	Receptor
Function	encodes a member of the sortilin family of VPS10P domain receptors.
Subcellular Localization	- Di-leucine motif (DDQSDL) — Mediates endosomal sorting
Amino Acids	835 aa
Exons	24
Pathways	Neurogenesis
UniProt ID	Q9Y6I9
NCBI Gene ID	22999
Ensembl ID	ENSG00000145945
OMIM	606284
GeneCards	SORCS2
Human Protein Atlas	SORCS2
Associated Diseases	neurodegeneration
KG Connections	45 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SORCS2 — AlphaFold Q9Y6I9 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

SORCS2 Gene

gene · 2710 words

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Pathway Diagram

graph TD
    SORCS2["SORCS2"]
    Alzheimer["Alzheimer"]
    SORCS2 -->|"regulates"| Alzheimer
    Neurodegeneration["Neurodegeneration"]
    SORCS2 -->|"regulates"| Neurodegeneration
    Aging["Aging"]
    SORCS2 -->|"regulates"| Aging
    Parkinson["Parkinson"]
    SORCS2 -->|"regulates"| Parkinson
    SORLA["SORLA"]
    SORCS2 -->|"associated with"| SORLA
    SORCS3["SORCS3"]
    SORCS2 -->|"associated with"| SORCS3
    Neurogenesis["Neurogenesis"]
    SORCS2 -->|"regulates"| Neurogenesis
    Neuron["Neuron"]
    SORCS2 -->|"regulates"| Neuron
    BDNF["BDNF"]
    SORCS2 -->|"regulates"| BDNF
    SORCS3["SORCS3"]
    SORCS2 -->|"regulates"| SORCS3
    SYNAPSE["SYNAPSE"]
    SORCS2 -->|"regulates"| SYNAPSE
    ENDOSOME["ENDOSOME"]
    SORCS2 -->|"regulates"| ENDOSOME
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    SORCS2 -->|"regulates"| PARKINSON_S_DISEASE
    SORCS1["SORCS1"]
    SORCS1 -->|"associated with"| SORCS2
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"regulates"| SORCS2
    SORL1["SORL1"]
    SORL1 -->|"regulates"| SORCS2
    SORCS1["SORCS1"]
    SORCS1 -->|"regulates"| SORCS2
    PARKINSON["PARKINSON"]
    PARKINSON -->|"regulates"| SORCS2
    ENDOSOMES["ENDOSOMES"]
    ENDOSOMES -->|"regulates"| SORCS2
    SORLA["SORLA"]
    SORLA -->|"associated with"| SORCS2
    SORCS3["SORCS3"]
    SORCS3 -->|"associated with"| SORCS2
    AND["AND"]
    AND -->|"associated with"| SORCS2
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"regulates"| SORCS2
    AGING["AGING"]
    AGING -->|"regulates"| SORCS2
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"regulates"| SORCS2
    SYNAPSE["SYNAPSE"]
    SYNAPSE -->|"regulates"| SORCS2
    GENES["GENES"]
    GENES -->|"regulates"| SORCS2
    BDNF["BDNF"]
    BDNF -->|"regulates"| SORCS2
    SORCS3["SORCS3"]
    SORCS3 -->|"regulates"| SORCS2
    AND["AND"]
    AND -->|"regulates"| SORCS2

Outgoing (28)

Target	Relation	Type	Str
Neurotrophic Signaling	modulates	pathway	0.85
Proneurotrophins	mediates	protein	0.85
Alzheimer	regulates	disease	0.65
Parkinson	regulates	disease	0.65
Aging	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
SYNAPSE	regulates	gene	0.60
Raf	regulates	protein	0.60
SORCS3	associated_with	gene	0.60
BDNF	regulates	gene	0.60
SORCS3	regulates	gene	0.60
Neurogenesis	regulates	pathway	0.60
Neuron	regulates	cell_type	0.60
PARKINSON	regulates	gene	0.60
Bdnf	regulates	protein	0.60
ALZHEIMER	transports	gene	0.60
Neurogenesis	transports	pathway	0.60
Neuron	transports	cell_type	0.60
SORLA	associated_with	gene	0.60
ENDOSOME	regulates	gene	0.60
PARKINSON'S DISEASE	regulates	gene	0.60
ENDOSOMES	regulates	gene	0.60
Neuron	expressed_in	cell_type	0.55
SORCS1	regulates	protein	0.50
SORL1	regulates	gene	0.50
SORCS1	associated_with	protein	0.50
SORTILIN	associated_with	protein	0.50
SORTILIN	regulates	protein	0.50

Incoming (17)

Source	Relation	Type	Str
SORCS1	associated_with	gene	0.60
SORL1	regulates	gene	0.60
SORCS1	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
PARKINSON	regulates	gene	0.60
ENDOSOMES	regulates	gene	0.60
AGING	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
SYNAPSE	regulates	gene	0.60
GENES	regulates	gene	0.60
NEURODEGENERATIVE DISEASES	regulates	gene	0.60
SORLA	associated_with	gene	0.60
SORCS3	associated_with	gene	0.60
BDNF	regulates	gene	0.60
SORCS3	regulates	gene	0.60
CLTC	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SORCS2 in their description or question text

No additional research found