gene

CD9

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CD9: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

130Connections

0Hypotheses

0Analyses

50Outgoing

33Incoming

2Experiments

0Debates

Summary

CD9 (CD9 molecule) - a tetraspanin protein involved in cell adhesion, exosome biology, and membrane organization with relevance to neurodegenerative diseases

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	CD9
Aliases	CD9 molecule
Chromosome	12p21.3
Function	encodes a member of the tetraspanin family of membrane proteins, which play crucial roles in cell adhesion, membrane organization, and intercellular communication through exosome formation.
Primary Expression	various cell types within the central nervous system:
Molecular Weight	25 kDa
Amino Acids	228 aa
Exons	8
Pathways	Akt, Epigenetic, Mtor, Pi3K, unfolded protein response
Ensembl ID	ENSG00000010278
GeneCards	CD9
Human Protein Atlas	CD9
Intracellular N- and C-termini	both are short and located in the cytoplasm
Facilitated signal transduction	by bringing together signaling components
Membrane fusion events	particularly relevant for exosome release and cell-cell fusion
Associated Diseases	Aging, Als, Alzheimer, Inflammation, Ms, Neurodegeneration
Interactions	Actin, AGING, AKT, AKT1, ALZHEIMER, AND
KG Connections	130 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CD9

gene · 1707 words

→

Pathway Diagram

graph TD
    CD9["CD9"]
    Als{"Als"}
    CD9 -->|"activates"| Als
    Ms{"Ms"}
    CD9 -->|"activates"| Ms
    Hepatitis{"Hepatitis"}
    CD9 -->|"activates"| Hepatitis
    Parkinson{"Parkinson"}
    CD9 -->|"expressed in"| Parkinson
    Dementia{"Dementia"}
    CD9 -->|"expressed in"| Dementia
    ALS{"ALS"}
    CD9 -->|"activates"| ALS
    Epigenetic(["Epigenetic"])
    CD9 -->|"activates"| Epigenetic
    GAIN["GAIN"]
    CD9 -->|"activates"| GAIN
    TREM2["TREM2"]
    CD9 -->|"activates"| TREM2
    PMP22["PMP22"]
    CD9 -->|"expressed in"| PMP22
    MTDNA["MTDNA"]
    CD9 -->|"activates"| MTDNA
    AND["AND"]
    CD9 -->|"activates"| AND
    NASH_diet["NASH diet"]
    NASH_diet -->|"activates"| CD9
    NASH{"NASH"}
    NASH -->|"activates"| CD9
    GAIN -->|"activates"| CD9
    TREM2 -->|"activates"| CD9
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"expressed in"| CD9
    MITOCHONDRIAL_DNA["MITOCHONDRIAL DNA"]
    MITOCHONDRIAL_DNA -->|"expressed in"| CD9
    style CD9 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (97)

Target	Relation	Type	Str
Als	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Senescence	activates	disease	0.65
Ms	associated_with	disease	0.65
Hepatitis	activates	disease	0.65
Ms	activates	disease	0.65
ALS	interacts_with	disease	0.65
Als	activates	disease	0.65
Parkinson	expressed_in	disease	0.65
unfolded protein response	participates_in	pathway	0.65
Als	interacts_with	disease	0.65
ALS	activates	disease	0.65
Dementia	expressed_in	disease	0.65
Aging	phosphorylates	disease	0.65
Als	therapeutic_target	disease	0.65
Alzheimer	phosphorylates	disease	0.65
Parkinson	phosphorylates	disease	0.65
Als	phosphorylates	disease	0.65
Neurodegeneration	phosphorylates	disease	0.65
CD63	interacts_with	gene	0.60
PARKINSON	phosphorylates	gene	0.60
ALZHEIMER	phosphorylates	gene	0.60
P53	activates	gene	0.60
AGING	phosphorylates	gene	0.60
ASTROCYTES	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
Neuron	associated_with	cell_type	0.60
Astrocyte	therapeutic_target	cell_type	0.60
App	therapeutic_target	protein	0.60
CD81	interacts_with	gene	0.60
Actin	interacts_with	protein	0.60
Interleukin	interacts_with	protein	0.60
Fus	interacts_with	protein	0.60
App	interacts_with	protein	0.60
PI3K-AKT-mTOR signaling	participates_in	pathway	0.60
lipid metabolism	participates_in	pathway	0.60
oligodendrocytes	expressed_in	cell_type	0.60
astrocytes	expressed_in	cell_type	0.60
GAIN	activates	gene	0.60
TREM2	activates	gene	0.60
Epigenetic	activates	pathway	0.60
EXOSOMES	interacts_with	gene	0.60
ENDOSOMES	biomarker_for	gene	0.60
MOG	biomarker_for	gene	0.60
NEURODEGENERATIVE DISEASES	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60

Incoming (33)

Source	Relation	Type	Str
NASH diet	activates	phenotype	0.80
NASH	activates	disease	0.64
PARKINSON'S DISEASE	expressed_in	gene	0.60
MITOCHONDRIAL DNA	expressed_in	gene	0.60
CD63	associated_with	gene	0.60
GAIN	activates	gene	0.60
TREM2	activates	gene	0.60
AND	activates	gene	0.60
CD63	activates	gene	0.60
SLC3A2	interacts_with	gene	0.60
AGING	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
P53	activates	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
CD63	interacts_with	gene	0.60
CD81	interacts_with	gene	0.60
CD81	associated_with	gene	0.60
CD63	expressed_in	gene	0.60
CD81	expressed_in	gene	0.60
AKT1	activates	gene	0.60
CD63	biomarker_for	gene	0.60
PI3K	activates	gene	0.60
TAU	associated_with	gene	0.60
CDK5	associated_with	gene	0.60
MAPT	associated_with	gene	0.60
NEFH	associated_with	gene	0.60
AKT	activates	gene	0.60
LAMP1	interacts_with	gene	0.60
APOE	activates	gene	0.55
CD81	activates	gene	0.55
AXL	activates	gene	0.55
CD63	co_mentioned	gene	0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (2)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Generation and characterization of TIGER mice with inducible CD9-GFP	validation		0.900	0.00	Transgenic TIGER mice	proposed	N/A
Characterization of astrocyte-derived EVs and microglia uptake	exploratory		0.850	0.00	TIGER mice cortical astrocytes	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CD9 in their description or question text

No additional research found