gene

TET2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TET2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

610Connections

3Hypotheses

5Analyses

50Outgoing

50Incoming

10Experiments

6Debates

Summary

TET2 (Tet Methylcytosine Dioxygenase 2): epigenetic regulator involved in DNA demethylation, 5-hydroxymethylcytosine formation, and linked to Alzheimer's disease, Parkinson's disease, and neurodegeneration.

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🧬 Gene Info

Gene Symbol	TET2
Full Name	Tet Methylcytosine Dioxygenase 2
Chromosome	4q24
Protein Family	TET family (Fe(II) and 2-oxoglutarate-dependent dioxygenases)
Protein Type	Epigenetic Regulator
Target Class	Epigenetic Regulator
Function	Small molecule enhancers of TET2 enzymatic activity or cofactor supplementation
Mechanism of Action	Small molecule enhancers of TET2 enzymatic activity or cofactor supplementation
Druggability	Low (0.42)
Clinical Stage	Phase II
Amino Acids	236 aa
Pathways	Amyloid, DNA_methylation, Epigenetic, Innate Immunity
UniProt ID	A7E237
NCBI Gene ID	93190
Ensembl ID	ENSG00000168769
OMIM	606839
GeneCards	TET2
Human Protein Atlas	TET2
Associated Diseases	AGING, Als, Alzheimer, Alzheimer's Disease
Known Drugs/Compounds	nicotinamide
Interactions	AGING, ALS, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK, AMYLOID
SciDEX Target	View Target Profile (6 clinical trials)
SciDEX Hypotheses	Epigenetic Memory Erasure via TET2 Activation TET2-Mediated Demethylation Rejuvenation Therapy Temporal TET2-Mediated Hydroxymethylation Cycling
KG Connections	609 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TET2 — AlphaFold A7E237 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

TET2 Gene

gene · 2244 words

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Pathway Diagram

graph TD
    TET2["TET2"]
    TET2 -->|"regulates"| DNA_methylation["DNA_methylation"]
    TET2 -->|"expressed in"| _middle_temporal_gyrus__spiny_["'middle temporal gyrus'_spiny_L3"]
    TET2 -->|"expressed in"| _middle_temporal_gyrus__aspiny["'middle temporal gyrus'_aspiny_L3"]
    TET2 -->|"activates"| Als["Als"]
    TET2 -->|"regulates"| Inflammation["Inflammation"]
    TET2 -->|"contributes to"| Cancer["Cancer"]
    TET2 -->|"contributes to"| Ms["Ms"]
    h_d2722680["h-d2722680"] -->|"target for"| TET2
    h_d7121bcc["h-d7121bcc"] -->|"target for"| TET2
    h_a90e2e89["h-a90e2e89"] -->|"target for"| TET2
    ASXL1["ASXL1"] -->|"activates"| TET2
    SF3B1["SF3B1"] -->|"activates"| TET2
    MYC["MYC"] -->|"expressed in"| TET2
    DNMT3A["DNMT3A"] -->|"activates"| TET2

Outgoing (369)

Target	Relation	Type	Str
BATF3	protects_against	gene	0.95
Alzheimer's Disease	protects_against	disease	0.95
Hematopoiesis	regulates	process	0.95
Myelopoiesis	regulates	process	0.95
CAR T Cell Expansion	inhibits	process	0.95
Clonal Hematopoiesis	involved_in	process	0.95
Epigenetics	involved_in	process	0.95
5-Hydroxymethylcytosine	regulates	compound	0.95
Myeloid Cells	expressed_in	cell_type	0.95
EPIGENETICS	involved_in	process	0.90
α-ketoglutarate-dependent dioxygenase activity	associated_with	phenotype	0.90
CAR T Cell Expansion	regulates	process	0.90
T CELL	regulates	entity	0.90
GENOMIC INSTABILITY	protects_against	entity	0.90
Car T Cell Expansion	inhibits	process	0.90
INNATE IMMUNITY	regulates	entity	0.90
MYELOPOIESIS	regulates	entity	0.90
HEMATOLOGICAL MALIGNANCIES	associated_with	entity	0.90
Innate Immune Homeostasis	regulates	process	0.90
Alzheimer's Disease	associated_with	disease	0.90
Alzheimer'S Disease	protects_against	disease	0.90
Epigenetic Regulation	mediates	mechanism	0.90
Neuronal Morphology	modulates	phenotype	0.90
BATF3	regulates	gene	0.90
Tumor	implicated_in	disease	0.90
Hematological Malignancies	associated_with	disease	0.90
BATF3	inhibits	gene	0.88
Amyloid-Beta Accumulation	inhibits	phenotype	0.88
Learning and Memory	protects_against	phenotype	0.87
innate immune homeostasis	promotes	phenotype	0.85
epigenetic regulation	involved_in	pathway	0.85
Astrogliosis	inhibits	process	0.85
Immune Response	regulates	process	0.85
Hippocampal Neurons	expressed_in	cell_type	0.85
Amyloid-Beta Toxicity	protects_against	process	0.85
LEUKAEMIA	therapeutic_target	entity	0.85
PROSTATE CANCER	therapeutic_target	entity	0.85
T CELL MEMORY	regulates	entity	0.85
Chronic Inflammation	regulates	process	0.85
T Cell Memory	regulates	phenotype	0.85
EPIGENETIC PROGRAMMING	involved_in	entity	0.85
neurons	expressed_in	cell_type	0.85
Microglia Activation	inhibits	process	0.85
Phagocytosis	upregulates	process	0.85
Hippocampal Dysfunction	biomarker_for	phenotype	0.84
PRO-INFLAMMATORY FACTORS	downregulates	protein	0.83
Neural Stem Cells	activates	cell_type	0.82
inflammation initiation	modulates	process	0.80
Neural Regeneration	regulates	process	0.80
inflammation resolution	modulates	process	0.80

Incoming (241)

Source	Relation	Type	Str
h-d7121bcc	targets	hypothesis	0.90
h-a90e2e89	targets	hypothesis	0.90
h-d2722680	targets	hypothesis	0.90
Arsenic	inhibits	protein	0.85
DNA	associated_with	gene	0.75
MICROGLIA	expressed_in	gene	0.70
INFLAMMATION	regulates	gene	0.70
GENES	activates	gene	0.70
OXIDATIVE STRESS	causes	phenotype	0.70
ALZHEIMER'S DISEASE	activates	gene	0.66
DNMT1	inhibits	gene	0.65
RAS	implicated_in	gene	0.60
NPM1	associated_with	gene	0.60
AMYLOID	regulates	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
AMYLOID	inhibits	gene	0.60
PHAGOCYTOSIS	activates	gene	0.60
PER	therapeutic_target	gene	0.60
AQP1	associated_with	gene	0.60
ATM	associated_with	gene	0.60
DNMT1	regulates	gene	0.60
DNMT1	activates	gene	0.60
TP53	associated_with	gene	0.60
CANCER	therapeutic_target	gene	0.60
RNA	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	transports	gene	0.60
ALZHEIMER	transports	gene	0.60
MYC	disrupts	gene	0.60
JAK2	regulates	gene	0.60
ASXL1	biomarker_for	gene	0.60
DNMT3A	biomarker_for	gene	0.60
SMAD6	interacts_with	gene	0.60
LRP5	regulates	gene	0.60
SMAD6	regulates	gene	0.60
LRP5	associated_with	gene	0.60
SMAD6	associated_with	gene	0.60
ABCC8	associated_with	gene	0.60
BMPR1A	associated_with	gene	0.60
BMPR1B	associated_with	gene	0.60
NOTCH3	associated_with	gene	0.60
SMAD1	associated_with	gene	0.60
SMAD4	associated_with	gene	0.60
ALZHEIMER	inhibits	gene	0.60
AGING	activates	gene	0.60
NEUROTOXICITY	activates	gene	0.60
INFLAMMATION	causes	gene	0.60
CANCER	causes	gene	0.60
MITOCHONDRIAL DNA	regulates	gene	0.60
AND	regulates	gene	0.60
MITOCHONDRIA	regulates	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Epigenetic Memory Erasure via TET2 Activation	0.741	neurodegeneration	Astrocyte reactivity subtypes in neurode
TET2-Mediated Demethylation Rejuvenation Therapy	0.706	neurodegeneration	Epigenetic clocks and biological aging i
Temporal TET2-Mediated Hydroxymethylation Cycling	0.657	neurodegeneration	Epigenetic reprogramming in aging neuron

Mentioning Analyses (5)

Scientific analyses that reference this entity

Experiments (10)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Tet2 modulation in Aβ42-injured mouse hippocampal neurons	exploratory	Alzheimer's disease	0.900	0.00	primary mouse hippocampal neur	proposed	N/A
AAV-mediated Tet2 modulation in 2×Tg-AD mice behavioral study	validation	Alzheimer's disease	0.900	0.00	young APPswe/PSEN1 double-tran	proposed	N/A
Tet2 expression analysis in aged 2×Tg-AD mouse brains	exploratory	Alzheimer's disease	0.850	0.00	APPswe/PSEN1 double-transgenic	proposed	N/A
Proposed experiment from debate on Epigenetic clocks and biological ag	falsification	Neurodegeneration	0.400	0.50	mouse	proposed	$450,000
CRISPR Gene Correction Approaches for CBS/PSP	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
DNA Damage Repair Deficiency Validation Study in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$7,500,000
Epigenetic Clocks in Neurodegeneration — Causal Drivers or Passive Mar	validation	Neurodegeneration	0.400	0.50	human	proposed	$3,000,000
Epigenetic Dysregulation Validation in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$7,500,000
Epigenetic Regulation Dysfunction in Alzheimer's and Parkinson's Disea	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$7,500,000
LRRK2/GBA Mutation Carrier Resilience — Why Some Carriers Never Develo	validation	Parkinson's Disease	0.400	0.50	human	proposed	$2,730,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Clonal Hematopoiesis in Nonmalignant Disease: Functional Consequences of Mutated [PMID:40929507]	Koh Y, Tengesdal IW, Jaiswal S	Annu Rev Pathol	2026	1
TET2 guards against unchecked BATF3-induced CAR T cell expansion. [PMID:36755094]	Jain N, Zhao Z, Feucht J, Koche R, Iyer	Nature	2023	1
Clonal Hematopoiesis of Indeterminate Potential: Current Understanding and Futur [PMID:36928826]	Singh I, Singh A	Curr Oncol Rep	2023	1
The function and regulation of TET2 in innate immunity and inflammation. [PMID:33085059]	Cong B, Zhang Q, Cao X	Protein Cell	2021	1
SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans. [PMID:33398264]	Turner JS, Kim W, Kalaidina E, Goss CW,	Res Sq	2020	1
Reply to Rosen: Temperature-growth relationship is robust. [PMID:31375623]	Diffenbaugh NS, Burke M	Proc Natl Acad Sci U S A	2019	1
Cryo-electron microscopy structures of human oligosaccharyltransferase complexes [PMID:31831667]	Ramírez AS, Kowal J, Locher KP	Science	2019	1
The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Mic [PMID:28930663]	Krasemann S, Madore C, Cialic R, Baufeld	Immunity	2017	1
The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with [PMID:28068668]	Britschgi A, Duss S, Kim S, Couto JP, Br	Nature	2017	1
CD161 defines a transcriptional and functional phenotype across distinct human T [PMID:25437561]	Fergusson JR, Smith KE, Fleming VM, Rajo	Cell Rep	2014	1
Genome-wide methylation profiles reveal quantitative views of human aging rates. [PMID:23177740]	Hannum G, Guinney J, Zhao L, Zhang L, Hu	Mol Cell	2013	1
Global epigenomic reconfiguration during mammalian brain development. [PMID:23828890]	Lister R, Mukamel EA, Nery JR, Urich M,	Science	2013	1
TET1 deficiency amplifies macrophage inflammatory signaling associated with Croh [PMID:41896302]	["Perez R", "Paul R", "Kumar P", "Tutkun	Inflammation research : offici	2026	0
Tet methylcytosine dioxygenase 2(TET2)-dependent epigenetic regulation in the pa [PMID:41811389]	Liu K, Hong Y, Gao Q, Huang J, Liu L, Li	Cellular and molecular life sc	2026	0
Clonal Hematopoiesis in Cardiovascular Risk: Focus on Inflammatory Mechanisms. [PMID:41899316]	["Sinnadurai S", "Honigberg M", "Meijers	Journal of clinical medicine	2026	0
Clonal Hematopoiesis and Risk of Trastuzumab-Related Cardiotoxic Effects. [PMID:41926089]	Park CS, Ryu G, Ahn HJ, Sun C, Lee SP, K	JAMA oncology	2026	0
IRG1-itaconate axis in immunometabolism: mechanistic roles and therapeutic poten [PMID:41743716]	Liu Y, Zhang P, Kong W, Li J, Yang H, Ba	Frontiers in immunology	2026	0
DNA Methylation in the Ovary and Uterus of Mammalian Animal Models: Implications [PMID:41751612]	Serej O, Kowalik MK, Rekawiecki R	Genes	2026	0
Chimeric antigen receptor T-cell therapies related to immune effector cell-assoc [PMID:41914034]	Zhang Y, Yang J, Xin H, Ai K, Yang M, Li	Chinese medical journal	2026	0
Promoter demethylation and protein O-GlcNAcylation-mediated enhancement of fatty [PMID:41360204]	Lin ZH, Chou PI, Chang JW, Lin ZC, Sun Y	J Nutr Biochem	2026	0

Debates (6)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning TET2 in their description or question text

No additional research found