concept

ASTROGLIOSIS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ASTROGLIOSIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

80Connections

0Hypotheses

2Analyses

33Outgoing

47Incoming

0Experiments

4Debates

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💡 Concept Info

Name	ASTROGLIOSIS
Key Genes/Proteins	APP, AQP4, BRAF, GADD45G
Related Diseases	ASTROCYTE REACTIVITY, AUTOPHAGY, DEMENTIA, GAUCHER DISEASE

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Reactive Astrogliosis

mechanism · 1707 words

→

Pathway Diagram

graph TD
    ASTROGLIOSIS["ASTROGLIOSIS"]
    ASTROGLIOSIS -->|"contributes to"| Alzheimer_s_Disease["Alzheimer's Disease"]
    ASTROGLIOSIS -->|"contributes to"| Disease_Progression["Disease Progression"]
    ASTROGLIOSIS -->|"interacts"| DEMENTIA["DEMENTIA"]
    ASTROGLIOSIS -->|"activates"| MICROGLIA["MICROGLIA"]
    ASTROGLIOSIS -->|"inhibits"| GFAP["GFAP"]
    Gap26["Gap26"] -->|"inhibits"| ASTROGLIOSIS
    TET2["TET2"] -->|"inhibits"| ASTROGLIOSIS
    HEXB["HEXB"] -->|"causes"| ASTROGLIOSIS
    GADD45G["GADD45G"] -->|"promotes"| ASTROGLIOSIS
    ASTROCYTE["ASTROCYTE"] -->|"regulates"| ASTROGLIOSIS
    STEM_CELLS["STEM CELLS"] -->|"causes"| ASTROGLIOSIS
    BRAF["BRAF"] -->|"activates"| ASTROGLIOSIS

Outgoing (33)

Target	Relation	Type	Str
Microstructural Changes	causes	phenotype	0.92
Chemical Changes	associated_with	phenotype	0.92
Scar Formation	associated_with	phenotype	0.90
Alzheimer Disease	associated_with	disease	0.90
Neurodegeneration	associated_with	process	0.90
Alzheimer's Disease	contributes_to	disease	0.90
Alzheimer's Disease	biomarker_for	disease	0.80
Disease Progression	contributes_to	phenotype	0.75
NEURON	activates	cell_type	0.70
GFAP	inhibits	gene	0.65
GFAP	regulates	gene	0.65
MICROGLIAL ACTIVATION	treats	phenotype	0.65
MICROGLIA	activates	cell_type	0.65
MICROGLIAL ACTIVATION	activates	phenotype	0.65
DEMENTIA	interacts_with	disease	0.65
MTOR	regulates	gene	0.65
NEUROINFLAMMATION	activates	phenotype	0.65
NEUROINFLAMMATION	treats	phenotype	0.65
NEUROINFLAMMATION	causes	phenotype	0.65
STROKE	targets	disease	0.65
CORPUS CALLOSUM	interacts_with	brain_region	0.65
JAK2	inhibits	gene	0.65
JAK2	activates	gene	0.65
GFAP	depleted_in	gene	0.55
AUTOPHAGY	implicated_in	phenotype	0.55
AUTOPHAGY	participates_in	phenotype	0.55
SPINAL CORD	associated_with	brain_region	0.50
STRIATUM	associated_with	brain_region	0.45
BRAINSTEM	associated_with	brain_region	0.45
SEMAGLUTIDE	associated_with	drug	0.45
HIPPOCAMPUS	associated_with	brain_region	0.45
CORTEX	associated_with	brain_region	0.45
BARICITINIB	associated_with	drug	0.45

Incoming (47)

Source	Relation	Type	Str
32762702	causes	paper	0.90
31606043	increased	paper	0.90
BDNF Deficiency	causes	phenotype	0.88
NA/H EXCHANGER	upregulates	protein	0.85
Gap26	inhibits	compound	0.85
TET2	inhibits	gene	0.85
Gap26	associated_with	compound	0.85
GADD45G	promotes	gene	0.80
HEXB	causes	gene	0.80
Gap26	inhibits	compound	0.80
SPINAL CORD	treats	brain_region	0.70
NEURONS	regulates	cell_type	0.70
SPINAL CORD	regulates	brain_region	0.70
MAPK	causes	gene	0.70
YKL-40	indicates	protein	0.70
GFAP	indicates	biomarker	0.70
TAU	activates	protein	0.65
TAU	treats	protein	0.65
SPINAL CORD INJURY	inhibits	disease	0.65
BRAF	activates	gene	0.65
AQP4	inhibits	gene	0.65
ASTROCYTE	inhibits	cell_type	0.65
STEM CELLS	causes	cell_type	0.65
AQP4	exacerbates	gene	0.65
NEURONS	inhibits	cell_type	0.65
MICROGLIA	inhibits	cell_type	0.65
ASTROCYTE	regulates	cell_type	0.65
GAUCHER DISEASE	interacts_with	disease	0.65
ASTROCYTE REACTIVITY	causes	phenotype	0.65
ASTROCYTE REACTIVITY	targets	phenotype	0.65
ASTROCYTE	activates	cell_type	0.65
SPINAL CORD	inhibits	brain_region	0.65
GRN	exacerbates	gene	0.65
STAT3	causes	gene	0.65
NEURON	interacts_with	cell_type	0.65
ASTROCYTE	causes	cell_type	0.65
NECROPTOSIS	inhibits	phenotype	0.65
GADD45G	causes	gene	0.64
GFAP	biomarker_for	gene	0.60
STAT3	implicated_in	gene	0.55
GLIAL FIBRILLARY ACIDIC PROTEIN	associated_with	biomarker	0.50
APP	associated_with	gene	0.50
INTERNEURONS	associated_with	cell_type	0.50
CORPUS CALLOSUM	associated_with	brain_region	0.45
TEMPORAL LOBE	associated_with	brain_region	0.45
DENTATE GYRUS	associated_with	brain_region	0.45
BASAL GANGLIA	associated_with	brain_region	0.45