| Gene Symbol | TET2 |
| Full Name | Tet Methylcytosine Dioxygenase 2 |
| Chromosome | 4q24 |
| Protein Family | TET family (Fe(II) and 2-oxoglutarate-dependent dioxygenases) |
| Protein Type | Epigenetic Regulator |
| Target Class | Epigenetic Regulator |
| Function | Small molecule enhancers of TET2 enzymatic activity or cofactor supplementation |
| Mechanism of Action | Small molecule enhancers of TET2 enzymatic activity or cofactor supplementation |
| Druggability | Low (0.42) |
| Clinical Stage | Phase II |
| Amino Acids | 236 aa |
| Pathways | Amyloid, DNA_methylation, Epigenetic, Innate Immunity |
| UniProt ID | A7E237 |
| NCBI Gene ID | 93190 |
| Ensembl ID | ENSG00000168769 |
| OMIM | 606839 |
| GeneCards | TET2 |
| Human Protein Atlas | TET2 |
| Associated Diseases | AGING, Als, Alzheimer, Alzheimer's Disease |
| Known Drugs/Compounds | IDH1/2 inhibitors, nicotinamide, Vitamin C |
| Interactions | AGING, ALS, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK, AMYLOID |
| SciDEX Target | View Target Profile (6 clinical trials) |
| SciDEX Hypotheses | Epigenetic Memory Erasure via TET2 Activation TET2-Mediated Demethylation Rejuvenation Therapy Temporal TET2-Mediated Hydroxymethylation Cycling |
| KG Connections | 611 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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