Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Tryptophan: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Serotonin | mediates | compound | 0.95 |
| Serotonin | activates | compound | 0.90 |
| Serotonin | interacts_with | compound | 0.90 |
| Indole Derivatives | product_of | compound | 0.85 |
| major depressive disorder | biomarker_for | disease | 0.85 |
| Neurodegeneration | protects_against | disease | 0.80 |
| NEUROINFLAMMATION | inhibits | process | 0.75 |
| Alzheimer's disease | biomarker_for | disease | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| IDO1 | catalyzes | protein | 0.72 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Restoring Neuroprotective Tryptophan Metabolism via Targeted | 0.612 | neurodegeneration | What are the mechanisms by which gut mic |
| Microbiome-Derived Tryptophan Metabolite Neuroprotection | 0.427 | neurodegeneration | What are the mechanisms by which gut mic |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| IL-10 deficiency and VLC ceramide accumulation in inflammatory bowel d | validation | inflammatory bowel disease | 0.900 | 0.00 | IL-10 knockout mice | proposed | N/A |
| Gut-Brain Axis Pathogenesis in Parkinson's Disease — Mechanism and Int | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propagation | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Microbiome-Gut Barrier Signatures in ALS — Experiment Design | clinical | ALS | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Microbiome-Gut-Brain Axis in Alzheimer's Disease — mechanism and inter | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $7,500,000 |
| SCFA-Mediated Neuroinflammation in Alzheimer's Disease | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Microcephaly-associated protein WDR62 supports purine metabolism by interacting [PMID:41787126] | Morris MJ, Yeap YY, Edwards JR, Chen C, | EMBO J | 2026 | 0 |
| Nonvital Pulp Therapy in Primary Teeth Using Mineral Trioxide Aggregate Obturati [PMID:41928850] | Makiguchi T, Terauchi Y, Wong K, Bogen G | Case Rep Dent | 2026 | 0 |
| Gut Microbiota and Dopamine: Producers, Consumers, Enzymatic Mechanisms, and In [PMID:41595985] | Albani G, Chellamuthu VR, Morlacchi L, Z | Bioengineering (Basel, Switzer | 2025 | 0 |
| Gut microbiota-derived indoleacetic acid attenuates neuroinflammation and neurod [PMID:40640940] | Wang N, Sun C, Yang Y | J Neuroinflammation | 2025 | 0 |
| Chemically induced reprogramming to reverse cellular aging. [PMID:37437248] | Yang JH, Petty CA, Dixon-McDougall T, Lo | Aging | 2023 | 0 |
| A review on immunomodulatory effects of BPA analogues. [PMID:37204436] | ["Kodila A", "Franko N", "Sollner Dolenc | Archives of toxicology | 2023 | 0 |
| Mechanisms of peripheral levodopa resistance in Parkinson's disease. [PMID:35546556] | Beckers M, Bloem BR, Verbeek MM | NPJ Parkinson's disease | 2022 | 0 |
| Current Therapeutic Landscape and Safety Roadmap for Targeting the Aryl Hydrocar [PMID:35626744] | ["Faber S", "Lahoti T", "Taylor E", "Lew | Cells | 2022 | 0 |
| Melatonin metabolism, signaling and possible roles in plants. [PMID:32645752] | Back K | The Plant journal : for cell a | 2021 | 0 |
| FNDC5/Irisin System in Neuroinflammation and Neurodegenerative Diseases: Update [PMID:33562601] | ["Pignataro P", "Dicarlo M", "Zerlotin R | International journal of molec | 2021 | 0 |
| Bi-allelic loss of function variants in SLC30A5 as cause of perinatal lethal car [PMID:33547425] | Lieberwirth JK, Joset P, Heinze A, Hents | European journal of human gene | 2021 | 0 |
| Gene editing. [PMID:32641840] | Unknown | Nature biotechnology | 2020 | 0 |
| Targeting Aryl hydrocarbon receptor for next-generation immunotherapies: Selecti [PMID:31727470] | ["Dolciami D", "Ballarotto M", "Gargaro | European journal of medicinal | 2020 | 0 |
| Single-cell reconstruction of the adult human heart during heart failure and rec [PMID:31915373] | ["Wang L", "Yu P", "Zhou B", "Song J", " | Nature cell biology | 2020 | 0 |
| The Aryl Hydrocarbon Receptor: A Mediator and Potential Therapeutic Target for O [PMID:32947781] | ["Choudhary M", "Malek G"] | International journal of molec | 2020 | 0 |
| Physiologic maturation is both extrinsically and intrinsically regulated in prog [PMID:32047174] | ["Venugopalan P", "Cameron E", "Zhang X" | Scientific reports | 2020 | 0 |
| Environmental Regulation, Technological Innovation, and Export Competitiveness: [PMID:32102174] | Liu J, Xie J | International journal of envir | 2020 | 0 |
| Predicting Subjective Recovery from Lower Limb Surgery Using Consumer Wearables. [PMID:33442582] | Karas M, Marinsek N, Goldhahn J, Foschin | Digital biomarkers | 2020 | 0 |
| ilastik: interactive machine learning for (bio)image analysis. [PMID:31570887] | ["Berg S", "Kutra D", "Kroeger T", "Stra | Nature methods | 2019 | 0 |
| Incorporation of oxygen atoms as a mechanism for photoluminescence enhancement o [PMID:29904778] | ["Schwermann C", "Stiehm T", "Tonndorf P | Physical chemistry chemical ph | 2018 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning Tryptophan in their description or question text
No additional research found