concept

GUT-BRAIN AXIS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GUT-BRAIN AXIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

753Connections

2Hypotheses

1Analyses

50Outgoing

50Incoming

1Experiments

2Debates

Summary

GUT-BRAIN AXIS is a concept in neurodegeneration research. Key relationships include: activates, therapeutic target, regulates. Associated with ALS, Aging, Als. Connected to 344 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	GUT-BRAIN AXIS
Key Genes/Proteins	AGING, AKT, ALPHA-SYNUCLEIN, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE
Related Diseases	Aging, Als, ALS, Alzheimer, Alzheimer'S Disease
Related Pathways	Adaptive Immunity, Akt, Alpha-Synuclein

Pathway Diagram

graph TD
    GUT_BRAIN_AXIS["GUT-BRAIN AXIS"]
    GUT_BRAIN_AXIS -->|"target for"| Inflammation["Inflammation"]
    GUT_BRAIN_AXIS -->|"target for"| Schizophrenia["Schizophrenia"]
    GUT_BRAIN_AXIS -->|"target for"| Autism["Autism"]
    GUT_BRAIN_AXIS -->|"target for"| Anxiety["Anxiety"]
    GUT_BRAIN_AXIS -->|"target for"| Neuroinflammation["Neuroinflammation"]
    GUT_BRAIN_AXIS -->|"target for"| Bipolar["Bipolar"]
    GUT_BRAIN_AXIS -->|"target for"| Ms["Ms"]
    GUT_BRAIN_AXIS -->|"activates"| Als["Als"]
    gut_vascular_barrier["gut vascular barrier"] -->|"regulates"| GUT_BRAIN_AXIS
    vagus_nerve["vagus nerve"] -->|"regulates"| GUT_BRAIN_AXIS
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"target for"| GUT_BRAIN_AXIS
    DRP1["DRP1"] -->|"activates"| GUT_BRAIN_AXIS
    MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"] -->|"target for"| GUT_BRAIN_AXIS
    TPH2["TPH2"] -->|"activates"| GUT_BRAIN_AXIS
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"activates"| GUT_BRAIN_AXIS
    ANXIETY["ANXIETY"] -->|"activates"| GUT_BRAIN_AXIS

Outgoing (439)

Target	Relation	Type	Str
Inflammation	activates	disease	1.00
Inflammation	therapeutic_target	disease	0.95
Neuroinflammation	activates	disease	0.95
Sepsis-Associated Encephalopathy	involved_in	disease	0.95
Als	regulates	disease	0.95
Central Nervous System	mediates	process	0.95
CNS Inflammation	contributes_to	process	0.90
Central Nervous System Inflammation	associated_with	process	0.90
Sepsis-Associated Encephalopathy	contributes_to	disease	0.90
Alzheimer'S Disease Progression	modulates	phenotype	0.90
Brain Homeostasis	associated_with	process	0.90
Cognitive Impairment	modulates	phenotype	0.90
Cognitive Impairment	regulates	phenotype	0.90
Neurodegenerative Disorders	associated_with	disease	0.90
Parkinson'S Disease	involved_in	disease	0.90
Microbiota	activates	pathway	0.90
NEUROINFLAMMATION	activates	gene	0.90
Alzheimer's Disease Progression	modulates	phenotype	0.88
Als	therapeutic_target	disease	0.85
Alzheimer	therapeutic_target	disease	0.85
Central Nervous System Physiology	regulates	process	0.85
depression	modulates	disease	0.85
Cognition	modulates	phenotype	0.85
Alzheimer'S Disease	associated_with	disease	0.85
Amyotrophic Lateral Sclerosis	associated_with	disease	0.85
ALZHEIMER'S DISEASE	involved_in	disease	0.85
PARKINSON'S DISEASE	involved_in	disease	0.85
Neurodegeneration	activates	disease	0.85
Parkinson	activates	disease	0.85
Cognitive Dysfunction	involved_in	phenotype	0.85
Brain	mediates	cell_type	0.85
Alzheimer's Disease	associated_with	disease	0.85
Inflammation	associated_with	disease	0.85
Parkinson's Disease	associated_with	disease	0.85
Central Nervous System	modulates	cell_type	0.85
Parkinson	associated_with	disease	0.85
Als	activates	disease	0.85
Neuroinflammation	modulates	process	0.82
lipid metabolism	regulates	process	0.82
Parkinson's disease	mediates	disease	0.80
INFLAMMATION	associated_with	gene	0.80
neuropsychiatric disorders	implicated_in	disease	0.80
Alzheimer Disease	associated_with	disease	0.80
Neuroinflammation	contributes_to	process	0.80
Depression	associated_with	disease	0.80
Microbiota	therapeutic_target	pathway	0.80
Oxidative Stress	therapeutic_target	pathway	0.80
MICROGLIA	activates	gene	0.80
Depression	regulates	disease	0.75
Neuroinflammation	therapeutic_target	disease	0.75

Incoming (314)

Source	Relation	Type	Str
Gut Microbiota	regulates	process	0.95
Gut Microbiota	component_of	process	0.95
SDA-2026-04-01-gap-20260401-225155	investigates	analysis	0.95
Microbiota	component_of	process	0.95
Microbiota	regulates	process	0.95
gut microbiota	regulates	cell_type	0.92
Bacterial Metabolites	component_of	compound	0.90
39839307	modulates	paper	0.90
GBA	participates_in	gene	0.90
37934614	facilitates bidirectional communication between	paper	0.90
Neural Communication	component_of	pathway	0.90
gut microbiota dysbiosis	disrupts	phenotype	0.88
SNCA	involved_in	protein	0.85
HPA Axis	component_of	pathway	0.85
Short-Chain Fatty Acids	involved_in	compound	0.85
Acetate	involved_in	compound	0.85
Immune System	component_of	process	0.85
Pcs	modulates	compound	0.85
Gut Dysbiosis	causes	phenotype	0.85
Vagus Nerve	component_of	process	0.85
Gut Microbiota Dysbiosis	involved_in	biomarker	0.85
Enteric Glia	involved_in	cell_type	0.80
Serotonin	component_of	compound	0.80
BDNF	participates_in	gene	0.80
PARKINSON	associated_with	gene	0.80
PARKINSON'S DISEASE	associated_with	gene	0.80
INFLAMMATION	activates	gene	0.80
neuroinflammation	involves	disease	0.75
BDNF	involved_in	protein	0.75
gut barrier integrity	mediates	phenotype	0.70
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.70
Parkinson'S Disease	associated_with	disease	0.70
ALS	participates_in	gene	0.70
SNCA pathway	regulates	pathway	0.70
OXIDATIVE STRESS	therapeutic_target	gene	0.70
alpha_synuclein	regulates	protein	0.70
NLRP3	participates_in	gene	0.70
INFLAMMATION	associated_with	gene	0.70
ALZHEIMER	therapeutic_target	gene	0.70
vagus nerve	regulates	process	0.70
NEURODEGENERATION	activates	gene	0.70
gut vascular barrier	regulates	process	0.70
PARKINSON'S DISEASE	therapeutic_target	gene	0.70
INFLAMMATION	therapeutic_target	gene	0.70
OXIDATIVE STRESS	activates	gene	0.70
PARKINSON'S DISEASE	regulates	gene	0.70
PARKINSON'S DISEASE	activates	gene	0.70
PARKINSON	activates	gene	0.70
GBA1	interacts_with	gene	0.65
neurodegeneration	involves	disease	0.65

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Gut-Brain Axis M-Cell Modulation	0.629	-	Neuroinflammation and microglial priming
Gut-Brain Axis Microbiome Modulation	0.557	Alzheimer's disease	Neuroinflammation and microglial priming

Mentioning Analyses (1)

Scientific analyses that reference this entity

Gut Microbiome Analysis in Parkinson's Disease

neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.778

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
AhR transcriptional regulation of NEP gene	exploratory	Alzheimer's disease	0.850	0.00	Cell culture system	proposed	N/A

Related Papers (11)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Pseudostellaria heterophylla polysaccharide mitigates Alzheimer's-like pathology [PMID:38750854]	He C, Jiang J, Liu J, Zhou L, Ge Y, Yang	International journal of biolo	2024	1
Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Ca [PMID:35642214]	Wang M, Pan W, Xu Y, Zhang J, Wan J, Jia	J Inflamm Res	2022	1
Therapeutic strategies for hypertension: exploring the role of microbiota-derive [PMID:40637840]	Tortelote GG	Pediatr Nephrol	2026	0
Exploring the gut-kidney axis: Berberine's role in alleviating chronic kidney di [PMID:41344525]	Lu Z, Li Z, Gu S, Cai Y, Wu Y et al.	J Ethnopharmacol	2026	0
Rebalancing the inflammatory niche in allergic rhinitis ". [PMID:41360358]	Wang N, Tang Y	Clin Chim Acta	2026	0
Differentiating Damp-Heat and Cold-Damp Diarrhea in Rat Models via Gut Microbiot [PMID:41566926]	Zhang H, Song X, Mi W, Ji P, Wei Y et al	Microbiologyopen	2026	0
Cranberry extract-supplemented microbiota effluents enhance intestinal barrier i [PMID:41680408]	Cattero V, Mayer T, Veilleux A, Roussel	Scientific reports	2026	0
Exploring the Role of Microglial Cells in the Gut-Brain Axis Communication: A Sy [PMID:40662222]	Ortiz-Samur NS, Vijaya AK, Burokas A, Me	Journal of neurochemistry	2025	0
Microglia and gut microbiota: A double-edged sword in Alzheimer's disease. [PMID:39321881]	Bano N, Khan S, Ahamad S, Kanshana JS, D	Ageing research reviews	2024	0
The Gut Microbiota Modulates Neuroinflammation in Alzheimer's Disease: Elucidati [PMID:39460538]	["Yang Jianshe", "Liang Junyi", "Hu Niyu	CNS neuroscience & therapeutic	2024	0
Brain-Gut-Microbiota Axis in Alzheimer's Disease. [PMID:30646475]	["Kowalski Karol", "Mulak Agata"]	Journal of neurogastroenterolo	2019	0

Debates (2)

Multi-agent debates referencing this entity

How does the gut microbiome composition differ between PD patients and healthy c

closed · Rounds: 4 · Score: 0.70 · 2026-04-21

Is the gut microbiome a driver of PD pathology via SCFA depletion, or is dysbios

closed · Rounds: 4 · Score: 0.70 · 2026-04-16

Related Research

Hypotheses and analyses mentioning GUT-BRAIN AXIS in their description or question text

No additional research found