concept

SLEEP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SLEEP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

145Connections

5Hypotheses

0Analyses

44Outgoing

50Incoming

16Experiments

0Debates

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💡 Concept Info

Name	SLEEP
Key Genes/Proteins	ALZHEIMER DISEASE

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

REM Sleep Behavior Disorder (RBD) - Diagnostic Marker for Synucleinopathies

diagnostic · 1866 words

→

Pathway Diagram

graph TD
    SLEEP["SLEEP"]
    SLEEP -->|"activates"| Glymphatic_Pathway["Glymphatic Pathway"]
    SLEEP -->|"modulates"| CIRCADIAN_RHYTHM["CIRCADIAN RHYTHM"]
    SLEEP -->|"modulates"| Circadian_Rhythm["Circadian Rhythm"]
    SLEEP -->|"contributes to"| Healthy_Brain_Aging["Healthy Brain Aging"]
    SLEEP -->|"regulates"| HSPA1A["HSPA1A"]
    GABAergic_Interneurons["GABAergic Interneurons"] -->|"regulates"| SLEEP
    Circadian_Clocks["Circadian Clocks"] -->|"regulates"| SLEEP
    Caffeine["Caffeine"] -->|"modulates"| SLEEP
    Serotonin["Serotonin"] -->|"regulates"| SLEEP
    HSPA1A -->|"regulates"| SLEEP
    ADENOSINE_RECEPTORS["ADENOSINE RECEPTORS"] -->|"regulates"| SLEEP
    n_5_HT["5-HT"] -->|"modulates"| SLEEP
    MTNR1B["MTNR1B"] -->|"regulates"| SLEEP

Outgoing (44)

Target	Relation	Type	Str
Metabolite Clearance	promotes	process	0.95
β-amyloid	associated_with	protein	0.95
interstitial space	associated_with	process	0.95
Waste Product Removal	promotes	process	0.92
Glymphatic Pathway	activates	pathway	0.92
cerebrospinal fluid	modulates	compound	0.90
CIRCADIAN RHYTHM	modulates	entity	0.90
central nervous system	associated_with	brain_region	0.90
neurotoxic waste products	associated_with	compound	0.90
Glymphatic Transport	regulates	process	0.90
Metabolic Homeostasis	involved_in	process	0.90
Brain Homeostasis	associated_with	process	0.85
Circadian Rhythm	modulates	process	0.85
APOE	associated_with	protein	0.85
Interstitial Space	modulates	phenotype	0.85
Brain_Homeostasis	associated_with	process	0.85
cellular repair mechanisms	mediates	process	0.85
Neurodegeneration_Processes	modulates	process	0.80
Neurodegeneration	associated_with	disease	0.80
Healthy Brain Aging	contributes_to	phenotype	0.80
Healthy_Brain_Aging	promotes	phenotype	0.80
Cognitive Function	contributes_to	phenotype	0.80
Cancer	associated_with	disease	0.75
HSPA1A	regulates	protein	0.75
Cognition	correlates_with	phenotype	0.75
Alzheimer Disease	biomarker_for	disease	0.75
Cognitive Function	regulates	phenotype	0.70
TBI	co_discussed	entity	0.50
TDP-43	co_discussed	entity	0.50
STROKE	co_discussed	entity	0.50
SYNAPTIC PLASTICITY	co_discussed	entity	0.50
MICROGLIA	causes	entity	0.50
TREM2	co_discussed	entity	0.50
TAU	co_discussed	entity	0.50
T CELLS	co_discussed	entity	0.50
THALAMUS	co_discussed	entity	0.50
WHITE MATTER	co_discussed	entity	0.50
UNFOLDED PROTEIN RESPONSE	co_discussed	entity	0.50
TLR4	co_discussed	entity	0.50
SYNAPSE	co_discussed	entity	0.50
TNF	co_discussed	entity	0.50
STING	co_discussed	entity	0.50
T CELL	co_discussed	entity	0.50
SOD1	co_discussed	entity	0.50

Incoming (101)

Source	Relation	Type	Str
Circadian Clocks	regulates	process	0.90
Caffeine	modulates	compound	0.90
Serotonin	regulates	compound	0.90
GABAergic Interneurons	regulates	cell_type	0.90
HSPA1A	regulates	gene	0.85
Hsp70	associated_with	protein	0.85
ADENOSINE RECEPTORS	regulates	receptor	0.85
Brain Function	associated_with	process	0.80
5-HT	modulates	compound	0.75
melatonin receptor 2	regulates	gene	0.70
Alzheimer's Disease	modulates	disease	0.70
HSPA1A	associated_with	gene	0.60
ALZHEIMER DISEASE	associated_with	gene	0.60
MTNR1B	regulates	gene	0.60
NEURON	co_discussed	entity	0.50
NEURONS	co_discussed	entity	0.50
PARKINSON	co_discussed	entity	0.50
PARKINSON'S	co_discussed	entity	0.50
SCHIZOPHRENIA	co_discussed	entity	0.50
GBA	co_discussed	entity	0.50
LRRK2	co_discussed	entity	0.50
ALZHEIMER	co_discussed	entity	0.50
MONOCYTES	co_discussed	entity	0.50
APOE	co_discussed	entity	0.50
ALPHA-SYNUCLEIN	co_discussed	entity	0.50
BACE1	co_discussed	entity	0.50
FRONTOTEMPORAL	co_discussed	entity	0.50
FTD	co_discussed	entity	0.50
ALS	co_discussed	entity	0.50
C9ORF72	co_discussed	entity	0.50
MONOCYTE	co_discussed	entity	0.50
ALZHEIMER'S	co_discussed	entity	0.50
CIRCADIAN	co_discussed	entity	0.50
GLYMPHATIC	co_discussed	entity	0.50
AQP4	co_discussed	entity	0.50
ASTROCYTE	co_discussed	entity	0.50
CORTEX	co_discussed	entity	0.50
HIPPOCAMPUS	co_discussed	entity	0.50
HYPOTHALAMUS	co_discussed	entity	0.50
ER STRESS	co_discussed	entity	0.50
CALCIUM SIGNALING	co_discussed	entity	0.50
CYTOKINE	co_discussed	entity	0.50
INFLAMMASOME	co_discussed	entity	0.50
MULTIPLE SCLEROSIS	co_discussed	entity	0.50
BRAINSTEM	co_discussed	entity	0.50
CERAMIDE	co_discussed	entity	0.50
SENESCENCE	co_discussed	entity	0.50
AXON	co_discussed	entity	0.50
AKT	co_discussed	entity	0.50
MTOR	co_discussed	entity	0.50

Targeting Hypotheses (5)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Sleep-Dependent Glymphatic Clearance Expands the Therapeutic	0.780	neurodegeneration	What is the therapeutic window between t
Sleep Spindle-Synaptic Plasticity Enhancement	0.721	neurodegeneration	Sleep disruption as cause and consequenc
Biorhythmic Interference via Controlled Sleep Oscillations	0.661	neurodegeneration	Microglia-astrocyte crosstalk amplificat
Treat Glymphatic Failure by Coupling AQP4-Targeted Therapy t	0.630	neurodegeneration	How can AQP4 be effectively targeted the
A lower trazodone dose of 50-100 mg nightly may be sufficien	0.580	neurodegeneration	-

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (16)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Phenobarbital treatment efficacy study	clinical	intractable epilepsy	0.900	0.00	human patient and Gabra1+/-/Ga	proposed	N/A
Gabra1+/-/Gabrg2+/- mouse model characterization	validation	epilepsy with optic atrophy	0.900	0.00	Gabra1+/-/Gabrg2+/- mice	proposed	N/A
Optic nerve myelination analysis	exploratory	optic atrophy	0.880	0.00	Gabra1+/-/Gabrg2+/- mice	proposed	N/A
GABAA receptor subunit expression analysis	exploratory	epilepsy	0.850	0.00	Gabra1+/-/Gabrg2+/- mice	proposed	N/A
Brain Connectivity-Targeted tACS Trial in Early AD	clinical	Alzheimer's Disease	0.509	0.50	human postmortem brain tissue	proposed	$520,000
s:** - Test whether HCN1 knockout specifically in EC layer II accelera	falsification	Alzheimer's Disease	0.400	0.50	cell_line	proposed	$80,000
tACS Connectivity Trial in Early Alzheimer's	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
Brain Connectivity-Targeted tACS Trial in Early AD	clinical	Alzheimer's Disease	0.400	0.50	mouse	proposed	$730,000
DLB Cognitive Fluctuation Mechanism Experiment	clinical	Neurodegeneration	0.400	0.50	human	proposed	$6,550,000
Migraine Cortical Hyperexcitability and Alzheimer's Disease Risk: Long	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
Neural Oscillation Dysfunction Validation in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
Non-Motor Symptom Progression in Parkinson's Disease — Mechanisms and	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000
Sleep and Circadian Dysfunction as Driver of Neurodegeneration	clinical	Neurodegeneration	0.400	0.50	human	proposed	$5,460,000
Sleep Disruption and Alzheimer's Disease — mechanism and intervention	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
Proposed experiment from debate on Astrocytes adopt A1 (neurotoxic) an	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$80,000
Non-Dopaminergic Neurotransmitter Degeneration in PD - Experiment Desi	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
A brain-to-gut signal controls intestinal fat absorption. [PMID:39261733]	Lyu Q, Xue W, Liu R, Ma Q, Kasaragod VB,	Nature	2024	1
Epilepsy plus blindness in microdeletion of GABRA1 and GABRG2 in mouse and human [PMID:37703949]	Zhang Q, Forster-Gibson C, Bercovici E,	Exp Neurol	2023	1
Pharmacogenetics of anxiety and depression in Alzheimer's disease. [PMID:36628952]	Cacabelos R, Carril JC, Corzo L, Pego R,	Pharmacogenomics	2023	1
Genetic factors in precocious puberty. [PMID:34665958]	Shim YS, Lee HS, Hwang JS	Clin Exp Pediatr	2022	1
Sleep drives metabolite clearance from the adult brain. [PMID:24136970]	Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Th	Science	2013	1
Effects of caffeine on sleep and cognition. [PMID:21531247]	Snel J, Lorist MM	Prog Brain Res	2011	1
Functional dissection of Timekeeper (Tik) implicates opposite roles for CK2 and [PMID:19536808]	Kunttas-Tatli E, Bose A, Kahali B, Bisho	Genesis	2009	1
CI-994 is a dual modulator of class I HDACs and Wnt/β-catenin signaling for the [PMID:41654970]	Lu W, Kawatani K, Ren Y	Alzheimers Res Ther	2026	0
Molecular brake on firing pattern transitions in MHbChAT neurons to mediate nico [PMID:41903536]	Zheng ZW, Min PX, Luo YL, Mao XF, Zhang	Neuron	2026	0
Estradiol modulates neuronal network hyperexcitability in select NDD risk genes. [PMID:41757108]	Pruitt A, Yang L, Lee S, Balafkan N, Sea	bioRxiv : the preprint server	2026	0
Prenatal alcohol exposure dysregulates the expression of clock genes and alters [PMID:41086861]	Reina-Campos M, Gallego-Landin I, Medran	Open biology	2025	0
Sleep-improving effect and the potential mechanism of Morus alba L. on mice. [PMID:39255910]	Kong X, Zhou X, Li R, Kang Q, Hao L, Zhu	Fitoterapia	2024	0
Vitamin D supplementation and COVID-19 risk: a population-based, cohort study. [PMID:34273098]	["Oristrell J", "Oliva J", "Casado E", "	Journal of endocrinological in	2022	0
Intracellular calcium homeostasis and its dysregulation underlying epileptic sei [PMID:36403388]	Zhou X, Chen Z, Xiao L, Zhong Y, Liu Y,	Seizure	2022	0
To beat Omicron, Delta and bird flu, Europe must pull together [PMID:34893768]	Desvars-Larrive Amélie	Nature	2021	0
Facilitating successful online meetings in healthcare. [PMID:33789331]	Dennis Sherrod; Cecil Holland	Nursing management	2021	0
Homeostatic plasticity and burst activity are mediated by hyperpolarization-acti [PMID:33547341]	Rátkai A, Tárnok K, Aouad HE, Micska B,	Scientific reports	2021	0
Machine learning reveals bilateral distribution of somatic L1 insertions in huma [PMID:33432196]	["Zhu X", "Zhou B", "Pattni R", "Gleason	Nature neuroscience	2021	0
Cryo-EM structures of full-length Tetrahymena ribozyme at 3.1 Å resolution. [PMID:34381213]	["Su Z", "Zhang K", "Kappel K", "Li S",	Nature	2021	0
Prevalence and follow-up of potentially inappropriate medication and potentially [PMID:32641251]	["van Loveren F", "van Berlo-van de Laar	Journal of geriatric oncology	2021	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SLEEP in their description or question text

No additional research found