concept

MIR-155

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MIR-155: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

98Connections

3Hypotheses

0Analyses

50Outgoing

44Incoming

0Experiments

0Debates

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💡 Concept Info

Name	MIR-155
Key Genes/Proteins	ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, APOE, AXIN1
Related Diseases	Aging, Als, ALS, Alzheimer
Related Pathways	Amyloid

Pathway Diagram

graph TD
    MIR_155["MIR-155"]
    MIR_155 -->|"promotes"| vascular_inflammation["vascular inflammation"]
    MIR_155 -->|"binds_to"| IRF2BP2["IRF2BP2"]
    MIR_155 -->|"promotes"| IL_6["IL-6"]
    MIR_155 -->|"expressed in"| Als["Als"]
    MIR_155 -->|"activates"| Alzheimer["Alzheimer"]
    MIR_155 -->|"activates"| Aging["Aging"]
    MIR_155 -->|"activates"| Neurodegeneration["Neurodegeneration"]
    MECP2["MECP2"] -->|"target for"| MIR_155
    MICRORNAS["MICRORNAS"] -->|"expressed in"| MIR_155
    CLEC7A["CLEC7A"] -->|"activates"| MIR_155
    AMYLOID["AMYLOID"] -->|"activates"| MIR_155
    ALZHEIMER["ALZHEIMER"] -->|"activates"| MIR_155
    RNA["RNA"] -->|"activates"| MIR_155
    MICROGLIA["MICROGLIA"] -->|"activates"| MIR_155
    PHAGOCYTOSIS["PHAGOCYTOSIS"] -->|"activates"| MIR_155

Outgoing (54)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:MIR-155	data_in	dataset_row	0.00
h-42f8fa19eb	targeted_by	hypothesis	1.00
vascular inflammation	promotes	process	0.93
Increased Mortality	associated_with	phenotype	0.90
Poor Outcomes	associated_with	phenotype	0.90
IRF2BP2	binds_to	gene	0.90
IL-6	promotes	protein	0.85
Neuroinflammation	upregulates	process	0.85
psoriasis	associated_with	disease	0.85
Alzheimer	regulates	disease	0.65
ALS	associated_with	disease	0.65
Als	expressed_in	disease	0.65
Neurodegeneration	activates	disease	0.65
Aging	activates	disease	0.65
Alzheimer	activates	disease	0.65
ALS	expressed_in	disease	0.65
Ras	therapeutic_target	protein	0.60
AND	expressed_in	gene	0.60
Microglia	activates	cell_type	0.60
MICRORNAS	expressed_in	gene	0.60
MECP2	expressed_in	gene	0.60
Rb	associated_with	protein	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
HNF4A	activates	gene	0.60
CCND1	activates	gene	0.60
GENES	activates	gene	0.60
MYC	activates	gene	0.60
YWHAZ	activates	gene	0.60
TXNIP	activates	gene	0.60
ALZHEIMER	regulates	gene	0.60
SOCS3	activates	gene	0.60
RELA	activates	gene	0.60
SPI1	activates	gene	0.60
TBP	activates	gene	0.60
Amyloid	regulates	pathway	0.60
Phagocytosis	activates	pathway	0.60
NTRK2	expressed_in	gene	0.60
MICRORNAS	associated_with	gene	0.60
RNA	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
AMYLOID	activates	gene	0.60
TREM2	activates	gene	0.60
MICROGLIA	activates	gene	0.60
Amyloid	activates	pathway	0.60
AND	associated_with	gene	0.60
EGR1	activates	gene	0.60
AND	activates	gene	0.60
MECP2	therapeutic_target	gene	0.60
ALZHEIMER	activates	gene	0.60
CLEC7A	activates	gene	0.60

Incoming (44)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:MIR-155	data_in	dataset_row	0.00
h-42f8fa19eb	targets	hypothesis	1.00
MICRORNAS	associated_with	gene	0.70
MIRNAS	associated_with	gene	0.60
CLEC7A	activates	gene	0.60
AMYLOID	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
RNA	activates	gene	0.60
MICROGLIA	activates	gene	0.60
MYH9	activates	gene	0.60
HUB GENES	regulates	gene	0.60
AMYLOID	regulates	gene	0.60
MECP2	therapeutic_target	gene	0.60
STAT3	activates	gene	0.60
MIRNAS	activates	gene	0.60
MICRORNAS	regulates	gene	0.60
RHEB	activates	gene	0.60
DGKQ	expressed_in	gene	0.60
PDE4B	expressed_in	gene	0.60
BDNF	expressed_in	gene	0.60
NEURODEGENERATION	activates	gene	0.60
APOE	activates	gene	0.60
AXIN1	activates	gene	0.60
MICRORNAS	expressed_in	gene	0.60
ALZHEIMER	regulates	gene	0.60
STAT1	activates	gene	0.60
GENES	associated_with	gene	0.60
CREB1	expressed_in	gene	0.60
MEF2C	expressed_in	gene	0.60
GAIN	regulates	gene	0.60
SPI1	activates	gene	0.60
SOCS3	activates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
PHAGOCYTOSIS	activates	gene	0.60
MYC	activates	gene	0.60
HNF4A	activates	gene	0.60
YWHAZ	activates	gene	0.60
RELA	activates	gene	0.60
AND	activates	gene	0.60
GENES	activates	gene	0.60
TXNIP	activates	gene	0.60
EGR1	activates	gene	0.60
CCND1	activates	gene	0.60
TBP	activates	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
miR-155/Interferon-gamma Feedback Loop as a Reversible Molec	0.843	neurodegeneration	How do different microglial subtypes (DA
Age-Accelerated miR-155 Upregulation Primes Nigral Microglia	0.610	neuroinflammation	How do regional, age, and sex-dependent
CX3CR1-Targeted AntimiR-155 Oligonucleotides for Microglial	0.530	pharmacology	How can CNS-selective HDAC/DNMT inhibito

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (7)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Changes in Circulating Levels of miR-30b During Minipuberty and Puberty in Girls [PMID:40899010]	Albrechtsen HM, Saritas G, Winge SB, Mai	J Clin Endocrinol Metab	2026
Epigenetics in chronic rhinosinusitis. [PMID:41442742]	Kumar N, Brar T, Lal D	Curr Opin Otolaryngol Head Nec	2026
Extracellular vesicles in type 2 diabetes exhibit elevated miR-155 cargo and Ann [PMID:41786286]	Jackson G, Islam H, de Souza Teixeira AA	Life Sci	2026
Decoding microRNA-Protein Interaction Networks in Alzheimer's Disease: Molecular [PMID:41918207]	Mishra R, Gupta JK	Curr Alzheimer Res	2026
Di-2-ethylhexylphthalate-induced miR155-5P promotes placental ferroptosis. [PMID:41937013]	Gu X, Sun F, Li Y, Yang S, Li Y	Int J Biol Macromol	2026
Extracellular Vesicles in Obesity: From Pathophysiological Mediators to Therapeu [PMID:41977323]	Pavlović N, Todorović P, Maglica M, Kopi	Int J Mol Sci	2026
Decoding microRNA-Protein Interaction Networks in Alzheimer's Disease: Molecular [PMID:41918207]	Mishra R, Gupta JK	Current Alzheimer research	2026

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MIR-155 in their description or question text

No additional research found