concept

NF-κB SIGNALING

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NF-κB SIGNALING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

37Connections

1Hypotheses

0Analyses

13Outgoing

24Incoming

0Experiments

0Debates

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💡 Concept Info

Name	NF-κB SIGNALING

Pathway Diagram

graph TD
    NF__B_SIGNALING["NF-kappaB SIGNALING"]
    NF__B_SIGNALING -->|"activates"| Inflammatory_Cytokine_Producti["Inflammatory Cytokine Production"]
    NF__B_SIGNALING -->|"activates"| Inflammation["Inflammation"]
    NF__B_SIGNALING -->|"promotes"| platelet_activation["platelet activation"]
    NF__B_SIGNALING -->|"promotes"| microvascular_thrombosis["microvascular thrombosis"]
    NF__B_SIGNALING -->|"interacts"| PI3K_AKT["PI3K/AKT"]
    NF__B_SIGNALING -->|"interacts"| AKT["AKT"]
    NF__B_SIGNALING -->|"mediates"| Macrophage_activation["Macrophage activation"]
    NF__B_SIGNALING -->|"activates"| inflammatory_cytokines["inflammatory cytokines"]
    NLRP6["NLRP6"] -->|"regulates"| NF__B_SIGNALING
    TAB1["TAB1"] -->|"upstream_of"| NF__B_SIGNALING
    Mitochondrial_Stress["Mitochondrial Stress"] -->|"activates"| NF__B_SIGNALING
    TRAF6["TRAF6"] -->|"upstream_of"| NF__B_SIGNALING
    ZBP1["ZBP1"] -->|"activates"| NF__B_SIGNALING
    CLU["CLU"] -->|"inhibits"| NF__B_SIGNALING
    PIMREG["PIMREG"] -->|"activates"| NF__B_SIGNALING
    COPA_mutations["COPA mutations"] -->|"activates"| NF__B_SIGNALING

Outgoing (13)

Target	Relation	Type	Str
Inflammatory Cytokine Production	activates	process	0.95
platelet activation	promotes	process	0.90
Inflammation	activates	process	0.90
Cisplatin Resistance	associated_with	phenotype	0.90
microvascular thrombosis	promotes	process	0.90
IL1B	upregulates	gene	0.88
IL6	upregulates	gene	0.88
TNF	upregulates	gene	0.88
Allergic Airway Inflammation	mediates	disease	0.88
PI3K/AKT	interacts_with	pathway	0.85
AKT	interacts_with	protein	0.82
Macrophage activation	mediates	cell_type	0.80
inflammatory cytokines	activates	protein	0.70

Incoming (24)

Source	Relation	Type	Str
NLRP6	regulates	protein	0.95
Lapiferin	inhibits	compound	0.92
TAB1	upstream_of	protein	0.92
TNF-α	activates	protein	0.90
Mitochondrial Stress	activates	process	0.90
TRAF6	upstream_of	protein	0.90
ZBP1	activates	protein	0.90
37069623	promotes	paper	0.90
Manganese	activates	compound	0.90
COPA mutations	activates	mechanism	0.85
PIMREG	activates	protein	0.85
COPA Mutations	activates	mechanism	0.85
CLU	inhibits	protein	0.85
H1N1 Virus	activates	process	0.85
Mitophagy	associated_with	process	0.85
PLCB3	associated_with	gene	0.80
LRP1	activates	gene	0.80
Small Extracellular Vesicles	inhibits	biomarker	0.80
mitophagy	associated_with	process	0.70
NEMO	activates	protein	0.70
DRD2	inhibits	gene	0.70
HCRTR1	involved_in	gene	0.60
TNF	upstream_of	gene	0.60
39817909	dampen	paper	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
LPS-TLR4-NF-κB Signaling Cascade as Therapeutic Target	0.619	neurodegeneration	Gut-Brain Axis in Parkinson's Disease: M

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (7)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Chrysophanol Attenuates Cognitive Impairment, Neuroinflammation, and Oxidative S [PMID:40728692]	Khan JZ, Zainab SR, Alattar A	Neurochem Res	2025
Qingda granule alleviates cerebral ischemia/reperfusion injury by inhibiting TLR [PMID:38184025]	Unknown	Journal of ethnopharmacology	2024
Ketogenic diet attenuates neuroinflammation and induces conversion of M1 microgl [PMID:37466915]	Sun W, Wang Q, Zhang R, Zhang N	Food & function	2023
NLRP3 inflammasome inhibition and M1-to-M2 microglial polarization shifting via [PMID:37137264]	Ibrahim Weam W; Skalicka-Woźniak K	International immunopharmacolo	2023
Microglia clear neuron-released α-synuclein via selective autophagy and prevent [PMID:32170061]	Choi I, Zhang Y, Seegobin SP	Nat Commun	2020
Lipocalin 2 induces neuroinflammation and blood-brain barrier dysfunction throug [PMID:32622362]	Mondal A, Bose D, Saha P	J Neuroinflammation	2020
RETRACTED: Hesperetin, a Citrus Flavonoid, Attenuates LPS-Induced Neuroinflammat [PMID:30884890]	["Muhammad T", "Ikram M", "Ullah R", "Re	Nutrients	2019

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NF-κB SIGNALING in their description or question text

No additional research found