concept

PI3K/AKT SIGNALING

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PI3K/AKT SIGNALING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

130Connections

2Hypotheses

1Analyses

12Outgoing

50Incoming

0Experiments

1Debates

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💡 Concept Info

Name	PI3K/AKT SIGNALING
Key Genes/Proteins	AKT, AMYLOID, AMYLOID-BETA, CHRNA7
Related Diseases	ALZHEIMER'S DISEASE, cancer, CANCER, CARCINOMA, Cognitive Impairment

Pathway Diagram

graph TD
    PI3K_AKT_SIGNALING["PI3K/AKT SIGNALING"]
    PI3K_AKT_SIGNALING -->|"downregulates"| MHC_I["MHC-I"]
    PI3K_AKT_SIGNALING -->|"involved_in"| Dermatomyositis["Dermatomyositis"]
    PI3K_AKT_SIGNALING -->|"activates"| Primordial_Follicle_Activation["Primordial Follicle Activation"]
    PI3K_AKT_SIGNALING -->|"activates"| ROS["ROS"]
    PI3K_AKT_SIGNALING -->|"activates"| TREM2["TREM2"]
    PI3K_AKT_SIGNALING -->|"activates"| SEPSIS["SEPSIS"]
    PI3K_AKT_SIGNALING -->|"activates"| QUERCETIN["QUERCETIN"]
    G3BP1["G3BP1"] -->|"activates"| PI3K_AKT_SIGNALING
    class_IA_PI3Ks["class IA PI3Ks"] -->|"activates"| PI3K_AKT_SIGNALING
    Juvenile_Dermatomyositis["Juvenile Dermatomyositis"] -->|"involved_in"| PI3K_AKT_SIGNALING
    PTEN["PTEN"] -->|"inhibits"| PI3K_AKT_SIGNALING
    curcumin["curcumin"] -->|"activates"| PI3K_AKT_SIGNALING
    BDNF["BDNF"] -->|"activates"| PI3K_AKT_SIGNALING
    ERBB2["ERBB2"] -->|"downregulates"| PI3K_AKT_SIGNALING

Outgoing (12)

Target	Relation	Type	Str
MHC-I	downregulates	protein	0.93
Dermatomyositis	involved_in	disease	0.90
Primordial Follicle Activation	activates	process	0.90
SRPK1	associated_with	concept	0.50
TP53	regulates	gene	0.45
QUERCETIN	activates	drug	0.35
TREM2	activates	gene	0.35
SEPSIS	activates	disease	0.35
SEPSIS	therapeutic_target	disease	0.35
ROS	activates	protein	0.35
RB1	activates	gene	0.30
TAU	phosphorylates	protein	0.30

Incoming (118)

Source	Relation	Type	Str
G3BP1	activates	protein	0.95
class IA PI3Ks	activates	protein	0.91
Juvenile Dermatomyositis	involved_in	disease	0.90
PTEN	inhibits	protein	0.85
BDNF	activates	protein	0.80
curcumin	activates	drug	0.80
MTOR	activates	gene	0.80
ERBB2	modulates	protein	0.80
ERBB2	downregulates	gene	0.80
GPR32	activates	protein	0.70
PI3K	activates	gene	0.65
AKT	activates	gene	0.65
α7nAChR	modulates	protein	0.60
Invasion	inhibits	pathway	0.50
INSR	activates	concept	0.50
Neuroprotection	activates	process	0.50
GASTRODIN	activates	gene	0.50
cancer	inhibits	disease	0.50
Pi3K/Akt	activates	pathway	0.50
Proteins	activates	protein	0.50
GSK3	activates	concept	0.50
oxidative stress	inhibits	phenotype	0.50
ferroptosis	inhibits	phenotype	0.50
Pi3K	protects_against	pathway	0.50
oxidative stress	protects_against	phenotype	0.50
QUERCETIN	activates	drug	0.50
Pi3K/Akt	protects_against	pathway	0.50
mTOR	associated_with	entity	0.50
EGFR	expressed_in	gene	0.50
PIK3CA	expressed_in	gene	0.50
MAPK1	expressed_in	gene	0.50
PIK3R1	expressed_in	gene	0.50
JAK2	expressed_in	gene	0.50
HRAS	expressed_in	gene	0.50
MAPK3	expressed_in	gene	0.50
Proteins	expressed_in	protein	0.50
apoptosis	associated_with	process	0.50
Glioma	associated_with	disease	0.50
TREM2	activates	gene	0.50
PI3K/AKT PATHWAY	activates	concept	0.50
MAPK	associated_with	gene	0.50
ferroptosis	protects_against	phenotype	0.50
Pi3K	activates	pathway	0.50
GLUT1	activates	protein	0.50
PKM2	activates	protein	0.50
HIF-1Α	activates	protein	0.50
MTORC1	activates	concept	0.50
Pi3K/Akt	regulates	pathway	0.50
Pi3K	regulates	pathway	0.50
inflammation	regulates	pathway	0.50

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
CD44-Mediated Src/PI3K/Akt Signaling Cascade	0.470	neuroinflammation	What molecular mechanisms mediate SPP1-i
Ultrasound-Responsive Liposomal Nanocarriers with Thermosens	0.380	drug delivery	Can IGFBPL1 therapeutics effectively cro

Mentioning Analyses (1)

Scientific analyses that reference this entity

Neuroinflammation resolution mechanisms and pro-resolving mediators

neurodegeneration | 2026-04-01 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

What are the mechanisms underlying neuroinflammation resolution mechanisms and p

closed · Rounds: 5 · Score: 0.95 · 2026-04-01

Related Research

Hypotheses and analyses mentioning PI3K/AKT SIGNALING in their description or question text

No additional research found