concept

PI3K/AKT/MTOR SIGNALING PATHWAY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PI3K/AKT/MTOR SIGNALING PATHWAY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

31Connections

0Hypotheses

0Analyses

21Outgoing

10Incoming

0Experiments

0Debates

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💡 Concept Info

Name	PI3K/AKT/MTOR SIGNALING PATHWAY

Pathway Diagram

graph TD
    PI3K_AKT_MTOR_SIGNALING_PATHWA["PI3K/AKT/MTOR SIGNALING PATHWAY"]
    PI3K_AKT_MTOR_SIGNALING_PATHWA -->|"contributes to"| Triple_Negative_Breast_Cancer_["Triple-Negative Breast Cancer Growth"]
    PI3K_AKT_MTOR_SIGNALING_PATHWA -->|"regulates"| Autophagy["Autophagy"]
    PI3K_AKT_MTOR_SIGNALING_PATHWA -->|"regulates"| Skeletal_Muscle_Aging["Skeletal Muscle Aging"]
    PI3K_AKT_MTOR_SIGNALING_PATHWA -->|"contributes to"| Angiogenesis["Angiogenesis"]
    PI3K_AKT_MTOR_SIGNALING_PATHWA -->|"contributes to"| Breast_Cancer_Proliferation["Breast Cancer Proliferation"]
    PI3K_AKT_MTOR_SIGNALING_PATHWA -->|"contributes to"| Breast_Cancer_Survival["Breast Cancer Survival"]
    PI3K_AKT_MTOR_SIGNALING_PATHWA -->|"inhibits"| Ferroptosis["Ferroptosis"]
    Polygonatum_Sibiricum_Polysacc["Polygonatum Sibiricum Polysaccharide"] -->|"activates"| PI3K_AKT_MTOR_SIGNALING_PATHWA
    Curcumin["Curcumin"] -->|"inhibits"| PI3K_AKT_MTOR_SIGNALING_PATHWA
    SPI1["SPI1"] -->|"activates"| PI3K_AKT_MTOR_SIGNALING_PATHWA
    LY294002["LY294002"] -->|"inhibits"| PI3K_AKT_MTOR_SIGNALING_PATHWA

Outgoing (21)

Target	Relation	Type	Str
Cancer Stem Cell Maintenance	involved_in	process	0.95
Triple-Negative Breast Cancer Growth	contributes_to	phenotype	0.95
Cancer Stem Cell Proliferation	activates	process	0.93
Epithelial To Mesenchymal Transition	regulates	process	0.90
Breast Cancer Progression	mediates	disease	0.90
Skeletal Muscle Aging	regulates	process	0.90
Breast Cancer Proliferation	contributes_to	phenotype	0.90
Breast Cancer Survival	contributes_to	phenotype	0.90
Angiogenesis	contributes_to	process	0.90
Skeletal Muscle Aging	regulates	phenotype	0.90
Autophagy	regulates	process	0.90
Autophagy	modulates	process	0.88
Ferroptosis	inhibits	process	0.88
Cancer Stem Cell Migration	involved_in	process	0.87
Microglial/Macrophage Inflammatory Response	mediates	process	0.85
Drug Resistance In Tumors	associated_with	phenotype	0.85
Mitochondrial Dysfunction	regulates	process	0.85
Mitochondrial Function	regulates	process	0.85
Therapy Resistance	contributes_to	process	0.85
Ferroptosis	regulates	process	0.85
neuroinflammation	regulates	process	0.80

Incoming (10)

Source	Relation	Type	Str
Polygonatum Sibiricum Polysaccharide	activates	compound	0.95
CircRNA	modulates	biomarker	0.95
PI3K/Akt/mTOR Inhibitors	inhibits	drug	0.92
Curcumin	inhibits	compound	0.92
MTOR	activates	gene	0.90
LY294002	inhibits	drug	0.90
SPI1	activates	gene	0.90
LY294002	inhibits	compound	0.90
Polygonatum Sibiricum Polysaccharide	activates	compound	0.85
Polygonatum sibiricum polysaccharide (PSP)	activates	compound	0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PI3K/AKT/MTOR SIGNALING PATHWAY in their description or question text

No additional research found