gene

aplp1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about aplp1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

123Connections

0Hypotheses

0Analyses

50Outgoing

38Incoming

0Experiments

0Debates

No summary available yet.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	APLP1
Full Name	Amyloid Beta Precursor-Like Protein 1
Chromosome	19q13.3
Function	is a type I transmembrane glycoprotein expressed predominantly in the nervous system, where it participates in diverse cellular processes including synapse development, plasticity, and network exci...
Primary Expression	the central nervous system with particularly high levels in the hippocampus (especially CA1 pyramidal neurons and dentate gyrus granule cells), cerebr
Amino Acids	770 aa
UniProt ID	[Q15804](https://www.uniprot.org/uniprot/Q15804)
Ensembl ID	ENSG00000105248
GeneCards	APLP1
Human Protein Atlas	APLP1
Associated Diseases	Alzheimer's disease
Interactions	AMYLOID, APOE, CLDN5, LAG3, MMP9, PARKINSON
KG Connections	23 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

APLP1 Gene

gene · 787 words

→

Pathway Diagram

graph TD
    aplp1["aplp1"]
    LAG3(["LAG3"])
    aplp1 -->|"interacts_with"| LAG3
    SYNUCLEIN["SYNUCLEIN"]
    aplp1 -->|"interacts_with"| SYNUCLEIN
    __SYNUCLEIN["alpha-SYNUCLEIN"]
    aplp1 -->|"interacts_with"| __SYNUCLEIN
    AMYLOID(["AMYLOID"])
    aplp1 -->|"interacts_with"| AMYLOID
    NEURONS["NEURONS"]
    aplp1 -->|"activates"| NEURONS
    Neurodegeneration{"Neurodegeneration"}
    Neurodegeneration -->|"activates"| aplp1
    APOE(["APOE"])
    APOE -->|"interacts_with"| aplp1
    style aplp1 fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (85)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:APLP1	data_in	dataset_row	0.00
Alpha-Synuclein Transmission	associated_with	process	0.95
LAG3	interacts_with	protein	0.95
Synaptic Plasticity	regulates	process	0.90
Alpha-Synuclein	associated_with	protein	0.85
Dopaminergic Neurodegeneration	contributes_to	phenotype	0.85
Alzheimer's Disease	correlates_with	disease	0.85
Als	protects_against	disease	0.65
Aging	activates	disease	0.65
Dementia	therapeutic_target	disease	0.65
Alzheimer	regulates	disease	0.65
Ms	regulates	disease	0.65
Cancer	contributes_to	disease	0.65
Parkinson	activates	disease	0.65
Vascular Dementia	interacts_with	disease	0.65
Als	associated_with	disease	0.65
Dementia	interacts_with	disease	0.65
Alzheimer	contributes_to	disease	0.65
Inflammation	interacts_with	disease	0.65
Vascular Dementia	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Neurodegeneration	activates	disease	0.65
Parkinson	therapeutic_target	disease	0.65
AND	activates	gene	0.60
AMYLOID	interacts_with	gene	0.60
PARKINSON'S DISEASE	therapeutic_target	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
Amyloid	interacts_with	pathway	0.60
Dopaminergic	activates	cell_type	0.60
Neuron	activates	cell_type	0.60
DEMENTIA	therapeutic_target	gene	0.60
Oxidative Stress	therapeutic_target	pathway	0.60
Blood-Brain Barrier	therapeutic_target	pathway	0.60
Endothelial	therapeutic_target	cell_type	0.60
PARKINSON'S DISEASE	activates	gene	0.60
MMP9	interacts_with	gene	0.60
IL-17	therapeutic_target	gene	0.60
Amyloid	therapeutic_target	protein	0.60
Il-1	therapeutic_target	protein	0.60
App	therapeutic_target	protein	0.60
AKT	activates	gene	0.60
APP	protects_against	gene	0.60
ADAM10	activates	gene	0.60
NPAS4	regulates	gene	0.60
APP	regulates	gene	0.60
SOD1	interacts_with	gene	0.60
APOE	interacts_with	gene	0.60
CLDN5	interacts_with	gene	0.60
Α-Synuclein	therapeutic_target	protein	0.60
MTHFR	interacts_with	gene	0.60

Incoming (38)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:APLP1	data_in	dataset_row	0.00
VPS35	regulates	protein	0.90
APP	interacts_with	protein	0.85
GALANGIN	binds_to	compound	0.80
CLDN5	interacts_with	gene	0.60
MMP9	interacts_with	gene	0.60
TNF	therapeutic_target	gene	0.60
curcumin	targets	drug	0.60
resveratrol	targets	drug	0.60
AMYLOID	interacts_with	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
DEMENTIA	therapeutic_target	gene	0.60
APP	associated_with	gene	0.60
APLP2	associated_with	gene	0.60
APLP2	regulates	gene	0.60
APOE	interacts_with	gene	0.60
SOD1	interacts_with	gene	0.60
APLP2	protects_against	gene	0.60
NEURODEGENERATION	activates	gene	0.60
PARKINSON	activates	gene	0.60
AND	activates	gene	0.60
TNF	interacts_with	gene	0.60
LAG3	interacts_with	gene	0.60
AGING	activates	gene	0.60
ALZHEIMER	contributes_to	gene	0.60
AMYLOID	associated_with	gene	0.60
CANCER	contributes_to	gene	0.60
ALZHEIMER'S DISEASE	contributes_to	gene	0.60
AMYLOID	therapeutic_target	gene	0.60
IL-17	therapeutic_target	gene	0.60
DEMENTIA	interacts_with	gene	0.60
INFLAMMATION	interacts_with	gene	0.60
NATURAL COMPOUNDS	interacts_with	gene	0.60
OXIDATIVE STRESS	interacts_with	gene	0.60
IL-17	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
APOE	interacts_with	gene	0.50
Neurodegeneration	activates	disease	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning aplp1 in their description or question text

No additional research found