gene

WDFY3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about WDFY3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

19Connections

0Hypotheses

0Analyses

8Outgoing

11Incoming

0Experiments

0Debates

Summary

WDFY3 is a gene implicated in neurodegeneration research. Key relationships include: associated with, expressed in, implicated in. Associated with Als, Ms. Connected to 17 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	WDFY3
Full Name	WD Repeat and FYVE Domain Containing 3
Chromosome	4q21.23
Protein Type	Receptor
Function	is an important component in the neurobiology of neurodegenerative diseases.
Subcellular Localization	PI3P-rich autophagosome formation sites
Amino Acids	528 aa
UniProt ID	[Q9Y4E5](https://www.uniprot.org/uniprot/Q9Y4E5)
Ensembl ID	ENSG00000155636
OMIM	617010
GeneCards	WDFY3
Human Protein Atlas	WDFY3
Phosphoinositide-Binding Region	Mediates membrane association
LC3-Interacting Region (LIR)	Directly interacts with LC3/GABARAP proteins on the autophagosome membrane<sup>[2]</sup>
Ubiquitinated protein aggregates	The protein contains ubiquitin-binding domains that recognize ubiquitinated misfolded proteins<sup>[3]</sup>
Associated Diseases	Als, Ms
Interactions	AND, GABARAP, LC3
KG Connections	19 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

WDFY3 Gene

gene · 1245 words

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Pathway Diagram

graph TD
    WDFY3["WDFY3"]
    Als{"Als"}
    WDFY3 -->|"associated with"| Als
    Ms{"Ms"}
    WDFY3 -->|"associated with"| Ms
    PIK3CB["PIK3CB"]
    WDFY3 -->|"expressed in"| PIK3CB
    RALB["RALB"]
    WDFY3 -->|"expressed in"| RALB
    AUTOPHAGY_RELATED_GENES["AUTOPHAGY-RELATED GENES"]
    WDFY3 -->|"associated with"| AUTOPHAGY_RELATED_GENES
    GNAI3["GNAI3"]
    WDFY3 -->|"expressed in"| GNAI3
    WIPI1["WIPI1"]
    WDFY3 -->|"expressed in"| WIPI1
    Autophagy(["Autophagy"])
    WDFY3 -->|"associated with"| Autophagy
    neurodegeneration["neurodegeneration"]
    WDFY3 -->|"implicated in"| neurodegeneration
    MIRNAS["MIRNAS"]
    MIRNAS -->|"associated with"| WDFY3
    C9ORF72["C9ORF72"]
    C9ORF72 -->|"expressed in"| WDFY3
    CD8["CD8"]
    CD8 -->|"associated with"| WDFY3
    LRRK2["LRRK2"]
    LRRK2 -->|"expressed in"| WDFY3
    IMMUNE_INFILTRATION["IMMUNE INFILTRATION"]
    IMMUNE_INFILTRATION -->|"associated with"| WDFY3
    MICRORNAS["MICRORNAS"]
    MICRORNAS -->|"associated with"| WDFY3
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"associated with"| WDFY3
    GBA["GBA"]
    GBA -->|"expressed in"| WDFY3
    style WDFY3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (8)

Target	Relation	Type	Str
Ms	associated_with	disease	0.65
Als	associated_with	disease	0.65
GNAI3	expressed_in	gene	0.60
PIK3CB	expressed_in	gene	0.60
Autophagy	associated_with	pathway	0.60
WIPI1	expressed_in	gene	0.60
RALB	expressed_in	gene	0.60
AUTOPHAGY-RELATED GENES	associated_with	gene	0.60

Incoming (11)

Source	Relation	Type	Str
AND	interacts_with	gene	0.60
C9ORF72	expressed_in	gene	0.60
CD8	associated_with	gene	0.60
LRRK2	expressed_in	gene	0.60
GBA	expressed_in	gene	0.60
MIRNAS	associated_with	gene	0.60
IMMUNE INFILTRATION	associated_with	gene	0.60
MICRORNAS	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
LC3	interacts_with	gene	0.60
GABARAP	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning WDFY3 in their description or question text

No additional research found