| Gene Symbol | WIPI1 |
| Aliases | WD Repeat Domain, Pyrin Interacting 1 |
| Chromosome | 1p34.2 |
| Protein Type | Gene |
| Function | WIPI1 localizes to the edges of the omegasome and is essential for the recruitment of downstream autophagy proteins (Proikas-Cezanne et al., 2004). |
| Molecular Weight | 49 kDa |
| Amino Acids | 449 aa |
| Exons | 10 |
| Pathways | Autophagy, Mitophagy, autophagy pathway, ubiquitin-proteasome |
| GeneCards | WIPI1 |
| Human Protein Atlas | WIPI1 |
| PI3P-binding site | The wedge-like structure at the N-terminus specifically recognizes phosphatidylinositol 3-phosphate (PI3P) on nascent autophagosomal membranes |
| LC3-interacting region (LIR) | WIPI1 contains a canonical LIR motif (positions 231-234: DDVTI) that enables binding to LC3/GABARAP family proteins |
| FRRG motif | The characteristic FRRG sequence in loop 7 of blade 7 is essential for phosphoinositide binding |
| Dimerization interface | WIPI1 can form homodimers, which may be important for its scaffolding function |
| Associated Diseases | Als, Diabetes, Ms |
| Interactions | AMPK, AND, ATG, ATG16L1, AUTOPHAGY, BECN1 |
| KG Connections | 84 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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