protein 589 words KG: VDAC1PROTEIN
Contents

VDAC1 Protein

🔬 Protein Info
Gene SymbolVDAC1
Full NameVoltage Dependent Anion Channel 1
AliasesVDAC1PROTEIN
Chromosome5q31
Protein TypeChannel
FunctionVDAC1 encodes the voltage-dependent anion channel 1, also known as porin.
Primary ExpressionBrain, Heart, Liver, Kidney
Molecular Weight31 kDa
PathwaysApoptosis, Autophagy, Er Stress, Glycolysis, Mitochondrial Function
UniProt IDP21796
NCBI Gene ID7416
Ensembl IDENSG00000110833
GeneCardsVDAC1
Human Protein AtlasVDAC1
Beta-barrel structure19 beta-strands forming a pore
Associated DiseasesALS, Alzheimer, Alzheimer's disease, amyotrophic lateral sclerosis
Interactionsaco2, ACO2, AKT, ALS, ALZHEIMER'S DISEASE, AMPK
SciDEX HypothesesMitochondrial Contact Site Stabilization
KG Connections499 knowledge graph edges
DatabasesGeneCardsHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

UniProtWikipedia

Related Hypotheses (6)

Metabolic Circuit Breaker via Lipid Droplet Modulation
Score: 0.71
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (7)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed

Related Experiments (4)

Live-cell microscopy of mitochondria-lysosome contacts and c
exploratory · proposed · Score: 0.90
s:** - Test MCU overexpression specifically in layer II neur
falsification · proposed · Score: 0.40
Exercise-BDNF-Mitophagy Biomarker Study in PD
clinical · proposed · Score: 0.40
MLCS Quantification in Parkinson's Disease
validation · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.