gene

PRKCI

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PRKCI: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

24Connections

0Hypotheses

0Analyses

16Outgoing

8Incoming

0Experiments

0Debates

Summary

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🧬 Gene Info

Gene Symbol	PRKCI
Chromosome	3q26.2
Protein Type	Kinase
Function	encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases.
Subcellular Localization	PRKCI localizes to multiple cellular compartments:
Pathways	Oxidative Stress, Apoptosis, Akt, Ferroptosis, Dna Methylation
Ensembl ID	ENSG00000163558
GeneCards	PRKCI
Human Protein Atlas	PRKCI
ATP binding	The kinase domain binds ATP as a phosphate donor
Protein kinase activity	Catalyzes phosphorylation of target proteins
Phospholipid binding	Responds to phospholipid signals (but not DAG)
Metal ion binding	Requires magnesium ions for catalytic activity
Zinc ion binding	Contains zinc finger domains for protein interactions
Associated Diseases	neurodegeneration
Interactions	AKT, ALZHEIMER, ALZHEIMER'S DISEASE, AND, NEURON
KG Connections	24 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PRKCI

gene · 2128 words

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Pathway Diagram

graph TD
    PRKCI["PRKCI"]
    Alzheimer{"Alzheimer"}
    PRKCI -->|"activates"| Alzheimer
    ALZHEIMER["ALZHEIMER"]
    PRKCI -->|"activates"| ALZHEIMER
    AMYLOID["AMYLOID"]
    PRKCI -->|"therapeutic_target"| AMYLOID
    FERROPTOSIS["FERROPTOSIS"]
    PRKCI -->|"therapeutic_target"| FERROPTOSIS
    AKT["AKT"]
    PRKCI -->|"activates"| AKT
    NEURON["NEURON"]
    PRKCI -->|"activates"| NEURON
    Oxidative_Stress(["Oxidative Stress"])
    PRKCI -->|"therapeutic_target"| Oxidative_Stress
    Apoptosis(["Apoptosis"])
    PRKCI -->|"therapeutic_target"| Apoptosis
    Akt(["Akt"])
    PRKCI -->|"activates"| Akt
    Ferroptosis(["Ferroptosis"])
    PRKCI -->|"therapeutic_target"| Ferroptosis
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"activates"| PRKCI
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"therapeutic_target"| PRKCI
    AND["AND"]
    AND -->|"activates"| PRKCI
    APP_PS1["APP/PS1"]
    APP_PS1 -->|"therapeutic_target"| PRKCI
    APP["APP"]
    APP -->|"therapeutic_target"| PRKCI

Outgoing (16)

Target	Relation	Type	Str
Alzheimer	activates	disease	0.65
AMYLOID	therapeutic_target	gene	0.60
FERROPTOSIS	therapeutic_target	gene	0.60
NEURON	activates	gene	0.60
Oxidative Stress	therapeutic_target	pathway	0.60
Apoptosis	therapeutic_target	pathway	0.60
Akt	activates	pathway	0.60
ALZHEIMER	activates	gene	0.60
Ferroptosis	therapeutic_target	pathway	0.60
AKT	activates	gene	0.60
VDAC1	therapeutic_target	gene	0.60
IL16	therapeutic_target	gene	0.60
DEPRESSION	therapeutic_target	gene	0.60
Dna Methylation	therapeutic_target	pathway	0.60
Epigenetic	therapeutic_target	pathway	0.60
App	therapeutic_target	protein	0.60

Incoming (8)

Source	Relation	Type	Str
APP	therapeutic_target	gene	0.60
DNA	therapeutic_target	gene	0.60
SORL1	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
AND	activates	gene	0.60
APP/PS1	therapeutic_target	gene	0.60
OXIDATIVE STRESS	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PRKCI in their description or question text

No additional research found