gene 1,007 words KG: VDAC1
Contents

VDAC1 — Voltage Dependent Anion Channel 1

🧬 Gene Info
Gene SymbolVDAC1
Full NameVoltage Dependent Anion Channel 1
Chromosome5q31
Protein TypeChannel
FunctionVDAC1 encodes the voltage-dependent anion channel 1, also known as porin.
Primary ExpressionBrain, Heart, Liver, Kidney
Molecular Weight31 kDa
PathwaysApoptosis, Autophagy, Er Stress, Glycolysis, Mitochondrial Function
UniProt IDP21796
NCBI Gene ID7416
Ensembl IDENSG00000110833
GeneCardsVDAC1
Human Protein AtlasVDAC1
Associated DiseasesALS, Alzheimer, Alzheimer's disease, amyotrophic lateral sclerosis
Interactionsaco2, ACO2, AKT, ALS, ALZHEIMER'S DISEASE, AMPK
SciDEX HypothesesMitochondrial Contact Site Stabilization
KG Connections499 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (26)

Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Metabolic Circuit Breaker via Lipid Droplet Modulation
Score: 0.71
Mechanosensitive Ion Channel Reprogramming
Score: 0.70
Lysosomal Calcium Channel Modulation Therapy
Score: 0.70
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
Extracellular Matrix Stiffness Modulation
Score: 0.69
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.69
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.67
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67
Mitochondrial RNA Granule Rescue Pathway
Score: 0.66
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66
Mitochondrial Calcium Buffering Enhancement via MCU Modulati
Score: 0.65
Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65
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Related Analyses (11)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived

Related Experiments (4)

Live-cell microscopy of mitochondria-lysosome contacts and c
exploratory · proposed · Score: 0.90
MLCS Quantification in Parkinson's Disease
validation · proposed · Score: 0.40
s:** - Test MCU overexpression specifically in layer II neur
falsification · proposed · Score: 0.40
Exercise-BDNF-Mitophagy Biomarker Study in PD
clinical · proposed · Score: 0.40

See Also (10)

Astrocytes
cell · KG edge: activates
ATP P2X3 Receptor Neurons
cell · KG edge: activates
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
ACO2 — Aconitase 2
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

VDAC1 activates DRP1
VDAC1 activates DNM1L
VDAC1 activates OPA1
DNM1L activates VDAC1
DRP1 activates VDAC1
VDAC1 activates AKT
CXCL10 activates VDAC1
STING activates VDAC1
CGAS activates VDAC1
IRF3 activates VDAC1

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