Contents

TSC2 — Tuberous Sclerosis Complex 2

🧬 Gene Info

Gene Symbol	TSC2
Full Name	Tuberous Sclerosis Complex 2
Function	The TSC1-TSC2 heterodimer localizes primarily to the cytoplasm and intracellular membranes, where it senses cellular energy status and growth factor signals.
Primary Expression	neurons and regulates synaptic function
Subcellular Localization	synapses and regulates dendritic spine morphology and synaptic plasticity
Molecular Weight	200 kDa
Amino Acids	807 aa
Pathways	mTOR, mtor, AMPK, PI3K
Ensembl ID	ENSG00000103197
GeneCards	TSC2
Human Protein Atlas	TSC2
Inhibition of Rheb	The GAP activity of TSC2 converts active GTP-bound Rheb to inactive GDP-bound Rheb, thereby inhibiting mTORC1 activation<sup>[2]</sup>
Energy sensing	TSC2 senses cellular energy (AMP/ATP ratio) through AMPK activation, inhibiting mTORC1 during energy deprivation
Growth factor regulation	PI3K/Akt signaling phosphorylates and inhibits TSC2, allowing mTORC1 activation in response to growth factors
Cell cycle control	TSC2 loss leads to uncontrolled cell proliferation
Associated Diseases	ALS, Diabetes, epilepsy, Ms, neurodegeneration, Parkinson
Known Drugs/Compounds	rapamycin
Interactions	ACETYL-COA, ACTB, Akt, AKT, AKT1, AKT3
KG Connections	349 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

No AI portrait yet

Knowledge Graph