gene

DEPDC5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DEPDC5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

90Connections

0Hypotheses

0Analyses

50Outgoing

30Incoming

0Experiments

0Debates

Summary

DEPDC5 is a gene implicated in neurodegeneration research. Key relationships include: activates, therapeutic target, interacts with. Associated with ALS, Als, Breast Cancer. Connected to 29 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	DEPDC5
Full Name	DEP Domain Containing 5
Chromosome	22q12.2
Function	is an important component in the neurobiology of neurodegenerative diseases.
Amino Acids	1623 aa
Exons	42
Pathways	mTOR, mtor, mTOR signaling, mTOR pathway
UniProt ID	O75157
NCBI Gene ID	9169
Ensembl ID	ENSG00000048991
GeneCards	DEPDC5
Human Protein Atlas	DEPDC5
Associated Diseases	Breast Cancer, epilepsy
Known Drugs/Compounds	rapamycin
Interactions	Akt, AKT3, AND, CANCER, CUL3, EPILEPSY
KG Connections	89 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: DEPDC5 — AlphaFold O75157 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    DEPDC5["DEPDC5"]
    MTOR["MTOR"]
    DEPDC5 -->|"inhibits"| MTOR
    mTOR["mTOR"]
    DEPDC5 -->|"inhibits"| mTOR
    Cancer{"Cancer"}
    DEPDC5 -->|"inhibits"| Cancer
    Tumor{"Tumor"}
    DEPDC5 -->|"activates"| Tumor
    Als{"Als"}
    DEPDC5 -->|"activates"| Als
    ALS{"ALS"}
    DEPDC5 -->|"activates"| ALS
    NPRL3["NPRL3"]
    DEPDC5 -->|"interacts with"| NPRL3
    Mtor(["Mtor"])
    DEPDC5 -->|"activates"| Mtor
    CUL3["CUL3"]
    DEPDC5 -->|"activates"| CUL3
    NPRL2["NPRL2"]
    DEPDC5 -->|"interacts with"| NPRL2
    neurodegeneration["neurodegeneration"]
    DEPDC5 -->|"implicated in"| neurodegeneration
    NPRL2 -->|"interacts with"| DEPDC5
    CUL3 -->|"activates"| DEPDC5
    NPRL3 -->|"interacts with"| DEPDC5
    LYSOSOME["LYSOSOME"]
    LYSOSOME -->|"activates"| DEPDC5
    UBIQUITIN["UBIQUITIN"]
    UBIQUITIN -->|"activates"| DEPDC5
    MTORC1["MTORC1"]
    MTORC1 -->|"activates"| DEPDC5
    CANCER["CANCER"]
    CANCER -->|"inhibits"| DEPDC5
    AND["AND"]
    AND -->|"activates"| DEPDC5
    style DEPDC5 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (60)

Target	Relation	Type	Str
GATOR1	component_of	protein	0.95
Breast Cancer	biomarker_for	disease	0.85
Breast Cancer	associated_with	disease	0.80
mTOR	inhibits	protein	0.70
MTOR	inhibits	protein	0.70
PI3K-AKT-mTOR signaling	participates_in	pathway	0.70
Epilepsy	therapeutic_target	disease	0.65
Epilepsy	activates	disease	0.65
ALS	activates	disease	0.65
Epilepsy	associated_with	disease	0.65
Als	activates	disease	0.65
Tumor	activates	disease	0.65
Cancer	inhibits	disease	0.65
EPILEPSY	therapeutic_target	gene	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
KLHL22	associated_with	gene	0.60
NPRL2	interacts_with	gene	0.60
Mtor	activates	pathway	0.60
Neuron	activates	cell_type	0.60
AND	associated_with	gene	0.60
NEURON	activates	gene	0.60
MTORC1	regulates	gene	0.60
MTOR	therapeutic_target	gene	0.60
MTOR	regulates	gene	0.60
autophagy pathway	participates_in	pathway	0.60
NPRL3	interacts_with	gene	0.60
CUL3	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
AKT3	activates	gene	0.60
Akt	activates	protein	0.60
epilepsy	regulates	disease	0.60
epilepsy	associated_with	disease	0.60
ATP	therapeutic_target	gene	0.60
Mtor	therapeutic_target	pathway	0.60
MTOR	activates	gene	0.60
LYSOSOME	activates	gene	0.60
cortex	expressed_in	brain_region	0.60
NPRL2	activates	entity	0.60
NPRL3	activates	entity	0.60
UBIQUITIN	degrades	entity	0.60
AND	activates	gene	0.60
TSC2	activates	gene	0.60
TSC1	activates	gene	0.60
RHEB	activates	gene	0.60
KLHL22	activates	gene	0.60
MTORC1	activates	gene	0.60
CANCER	inhibits	gene	0.60
PTEN	activates	gene	0.55
Neuron	expressed_in	cell_type	0.55
SYNAPSIN1	activates	protein	0.50

Incoming (30)

Source	Relation	Type	Str
KLHL22	degrades	protein	0.95
CUL3	mediates	protein	0.90
UBIQUITIN	mediates	entity	0.90
CUL3	degrades	protein	0.85
EPILEPSY	activates	gene	0.60
LYSOSOME	activates	gene	0.60
MTORC1	activates	gene	0.60
MTORC1	regulates	gene	0.60
CANCER	inhibits	gene	0.60
EPILEPSY	associated_with	gene	0.60
KLHL22	activates	gene	0.60
MTOR	activates	gene	0.60
AKT3	activates	gene	0.60
NPRL2	activates	gene	0.60
PIK3CA	activates	gene	0.60
TSC1	activates	gene	0.60
RHEB	activates	gene	0.60
TSC2	activates	gene	0.60
NPRL3	activates	gene	0.60
EPILEPSY	therapeutic_target	gene	0.60
NPRL3	interacts_with	gene	0.60
GENE MUTATIONS	therapeutic_target	gene	0.60
NPRL2	interacts_with	gene	0.60
CUL3	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
SYNAPSIN1	activates	gene	0.60
CANCER	upregulates	entity	0.60
rapamycin	targets	drug	0.55
EPILEPSY	interacts_with	gene	0.50
AKT3	co_expressed_with	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DEPDC5 in their description or question text

No additional research found