gene

NPRL3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NPRL3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

53Connections

0Hypotheses

0Analyses

32Outgoing

21Incoming

0Experiments

0Debates

Summary

NPRL3 is a gene implicated in neurodegeneration research. Key relationships include: activates, interacts with, implicated in. Associated with ALS, Als, Cancer. Connected to 16 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NPRL3
Full Name	NPR3-Like (GATOR1 Complex Subunit)
Aliases	HDRF1, FLJ14627
Chromosome	19q13.33
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	46 kDa
Amino Acids	418 aa
Pathways	mTOR, mtor, pathway: ### GATOR2 Complex Function
UniProt ID	Q9Y5Q3
NCBI Gene ID	84450
Ensembl ID	ENSG00000177732
OMIM	617052
GeneCards	NPRL3
Human Protein Atlas	NPRL3
Associated Diseases	epilepsy
Interactions	Akt, AKT3, AND, CANCER, CUL3, DEPDC5
KG Connections	53 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: NPRL3 — AlphaFold Q9Y5Q3 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

NPRL3 Gene

gene · 2242 words

→

NPRL3 Protein

protein · 758 words

→

Pathway Diagram

graph TD
    NPRL3["NPRL3"]
    Cancer{"Cancer"}
    NPRL3 -->|"activates"| Cancer
    Tumor{"Tumor"}
    NPRL3 -->|"activates"| Tumor
    Als{"Als"}
    NPRL3 -->|"activates"| Als
    ALS{"ALS"}
    NPRL3 -->|"activates"| ALS
    Mtor(["Mtor"])
    NPRL3 -->|"activates"| Mtor
    DEPDC5["DEPDC5"]
    NPRL3 -->|"interacts with"| DEPDC5
    CUL3["CUL3"]
    NPRL3 -->|"activates"| CUL3
    NPRL2["NPRL2"]
    NPRL3 -->|"interacts with"| NPRL2
    LYSOSOME["LYSOSOME"]
    NPRL3 -->|"activates"| LYSOSOME
    UBIQUITIN["UBIQUITIN"]
    NPRL3 -->|"activates"| UBIQUITIN
    MTORC1["MTORC1"]
    NPRL3 -->|"activates"| MTORC1
    CANCER["CANCER"]
    NPRL3 -->|"activates"| CANCER
    NPRL2 -->|"interacts with"| NPRL3
    CUL3 -->|"activates"| NPRL3
    DEPDC5 -->|"interacts with"| NPRL3
    style NPRL3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (32)

Target	Relation	Type	Str
Epilepsy	activates	disease	0.65
ALS	activates	disease	0.65
Epilepsy	therapeutic_target	disease	0.65
Tumor	activates	disease	0.65
Als	activates	disease	0.65
Cancer	activates	disease	0.65
TSC1	activates	gene	0.60
MTOR	activates	gene	0.60
NPRL2	activates	gene	0.60
Akt	activates	protein	0.60
Mtor	activates	pathway	0.60
RHEB	activates	gene	0.60
TSC2	activates	gene	0.60
KLHL22	activates	gene	0.60
AND	interacts_with	gene	0.60
cortex	expressed_in	brain_region	0.60
PIK3CA	activates	gene	0.60
DEPDC5	activates	gene	0.60
AKT3	activates	gene	0.60
EPILEPSY	therapeutic_target	gene	0.60
DEPDC5	interacts_with	gene	0.60
CUL3	activates	gene	0.60
NPRL2	interacts_with	gene	0.60
epilepsy	associated_with	disease	0.60
UBIQUITIN	activates	gene	0.60
AND	activates	gene	0.60
MTORC1	activates	gene	0.60
CANCER	activates	gene	0.60
LYSOSOME	activates	gene	0.60
PI3K-AKT-mTOR signaling	participates_in	pathway	0.60
RHEB	co_expressed_with	gene	0.50
PIK3CA	co_expressed_with	gene	0.50

Incoming (21)

Source	Relation	Type	Str
EPILEPSY	therapeutic_target	gene	0.60
NPRL2	interacts_with	gene	0.60
UBIQUITIN	activates	gene	0.60
TSC1	activates	gene	0.60
LYSOSOME	activates	gene	0.60
AND	interacts_with	gene	0.60
KLHL22	activates	gene	0.60
MTORC1	activates	gene	0.60
MTOR	activates	gene	0.60
AKT3	activates	gene	0.60
PIK3CA	activates	gene	0.60
EPILEPSY	activates	gene	0.60
CANCER	activates	gene	0.60
CUL3	activates	gene	0.60
DEPDC5	interacts_with	gene	0.60
DEPDC5	activates	entity	0.60
NPRL2	activates	entity	0.60
RHEB	activates	gene	0.50
TSC2	activates	gene	0.50
mTOR	activates	entity	0.50
MTOR	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NPRL3 in their description or question text

No additional research found