protein 606 words KG: TMEM119PROTEIN
Contents

TMEM119 Protein

🔬 Protein Info
Gene SymbolTMEM119
Full NameTransmembrane Protein 119
AliasesTMEM119 gene page
Chromosome12q14.1
Primary ExpressionCNS Microglia, Bone, Osteoblasts
Molecular Weight47 kDa
Amino Acids386 aa
Exons5
PathwaysCOMPLEMENT, NF-kB signaling, purinergic signaling, senescence, ubiquitin-proteasome
UniProt IDQ2M2W4
NCBI Gene ID344758
Ensembl IDENSG00000145681
OMIM616485
GeneCardsTMEM119
Human Protein AtlasTMEM119
Associated DiseasesAging, Als, Inflammation, Neuroinflammation
InteractionsAIF1, ALZHEIMER'S DISEASE, AMYLOID, AMYLOID-BETA, APOE, ASTROCYTE
KG Connections226 knowledge graph edges
DatabasesGeneCardsHPASTRING

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UniProtWikipedia

Related Hypotheses (7)

Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Microglial Purinergic Reprogramming
Score: 0.70
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56

Related Analyses (7)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

Related Experiments (5)

TREM2 Function in Alzheimer's Disease — From Risk Variant to
validation · proposed · Score: 0.45
s:** - GPR32 knockout in microglia should worsen neuroinflam
falsification · proposed · Score: 0.40
Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
Microglial Aging and Immune Memory in Neurodegeneration — Tr
validation · proposed · Score: 0.40
Microglial Contributions to Huntington's Disease Pathogenesi
validation · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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