gene 1,505 words KG: TMEM119
Contents

TMEM119 — Transmembrane Protein 119

🧬 Gene Info
Gene SymbolTMEM119
Full NameTransmembrane Protein 119
AliasesTMEM119 gene page
Chromosome12q14.1
Primary ExpressionCNS Microglia, Bone, Osteoblasts
Molecular Weight47 kDa
Amino Acids386 aa
Exons5
PathwaysCOMPLEMENT, NF-kB signaling, purinergic signaling, senescence, ubiquitin-proteasome
UniProt IDQ2M2W4
NCBI Gene ID344758
Ensembl IDENSG00000145681
OMIM616485
GeneCardsTMEM119
Human Protein AtlasTMEM119
Associated DiseasesAging, Als, Inflammation, Neuroinflammation
InteractionsAIF1, ALZHEIMER'S DISEASE, AMYLOID, AMYLOID-BETA, APOE, ASTROCYTE
KG Connections226 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (21)

Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE-TREM2 Interaction Modulation
Score: 0.74
Orexin-Microglia Modulation Therapy
Score: 0.71
Microglial Efferocytosis Enhancement via GPR32 Superagonists
Score: 0.70
Purinergic P2Y12 Inverse Agonist Therapy
Score: 0.70
Microglial Purinergic Reprogramming
Score: 0.70
Targeted Butyrate Supplementation for Microglial Phenotype M
Score: 0.70
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.68
Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67
Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
TREM2-Dependent Microglial Senescence Transition
Score: 0.58
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri
Score: 0.56
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Related Analyses (11)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed

Related Experiments (5)

Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
Microglial Aging and Immune Memory in Neurodegeneration — Tr
validation · proposed · Score: 0.40
TREM2 Function in Alzheimer's Disease — From Risk Variant to
validation · proposed · Score: 0.45
s:** - GPR32 knockout in microglia should worsen neuroinflam
falsification · proposed · Score: 0.40
Microglial Contributions to Huntington's Disease Pathogenesi
validation · proposed · Score: 0.40

See Also (12)

Astrocytes
cell · KG edge: biomarker_for
Astrocytes
entity · KG edge: biomarker_for
astrocyte-neuron-metabolic-coupling-parkinsons
general · KG edge: activates
AIF1 Gene
gene · KG edge: biomarker_for
C1QA Gene
gene · KG edge: biomarker_for

Knowledge Graph (12 edges)

TMEM119 expressed_in P2RY12
TMEM119 biomarker_for GAIN
TMEM119 expressed_in TREM2
UCHL1 interacts_with TMEM119
GFAP interacts_with TMEM119
TMEM119 interacts_with NFL
TMEM119 interacts_with UCHL1
TMEM119 interacts_with GFAP
P2RY12 expressed_in TMEM119
NFL interacts_with TMEM119

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