Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about LIQUID-LIQUID PHASE SEPARATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | LIQUID-LIQUID PHASE SEPARATION |
Knowledge base pages for this entity
graph TD
LIQUID_LIQUID_PHASE_SEPARATION["LIQUID-LIQUID PHASE SEPARATION"]
LIQUID_LIQUID_PHASE_SEPARATION -->|"involved_in"| Stress_Granules["Stress Granules"]
LIQUID_LIQUID_PHASE_SEPARATION -->|"mediates"| Biomolecular_Condensates["Biomolecular Condensates"]
LIQUID_LIQUID_PHASE_SEPARATION -->|"regulates"| Alpha_Synuclein_Aggregate["Alpha-Synuclein Aggregate"]
LIQUID_LIQUID_PHASE_SEPARATION -->|"involved_in"| Pulmonary_Hypertension["Pulmonary Hypertension"]
LIQUID_LIQUID_PHASE_SEPARATION -->|"regulates"| Mitophagy["Mitophagy"]
G3BP1["G3BP1"] -->|"mediates"| LIQUID_LIQUID_PHASE_SEPARATION
Alpha_Synuclein["Alpha-Synuclein"] -->|"involved_in"| LIQUID_LIQUID_PHASE_SEPARATION
Stress_Granules -->|"involved_in"| LIQUID_LIQUID_PHASE_SEPARATION
TRIAD3A["TRIAD3A"] -->|"mediates"| LIQUID_LIQUID_PHASE_SEPARATION
TDP_43_Oligomerization["TDP-43 Oligomerization"] -->|"involved_in"| LIQUID_LIQUID_PHASE_SEPARATION
G3BP1_Ubiquitination["G3BP1 Ubiquitination"] -->|"inhibits"| LIQUID_LIQUID_PHASE_SEPARATION| Target | Relation | Type | Str |
|---|---|---|---|
| condensate formation | mediates | process | 0.95 |
| Nanocondensates | associated_with | mechanism | 0.95 |
| Stress Granules | involved_in | process | 0.95 |
| Biomolecular Condensates | mediates | process | 0.95 |
| stress granules | drives | process | 0.95 |
| Stress Granules | mediates | process | 0.90 |
| Pathogenic Protein Aggregates | associated_with | phenotype | 0.90 |
| Stress Granules | promotes | process | 0.90 |
| Alpha-Synuclein Aggregate | regulates | mechanism | 0.90 |
| Mitophagy | regulates | process | 0.85 |
| Pulmonary Hypertension | involved_in | disease | 0.85 |
| protein aggregates | associated_with | phenotype | 0.85 |
| Pulmonary Hypertension | contributes_to | disease | 0.80 |
| Cell Cycle Regulation | involved_in | process | 0.80 |
| protein aggregates | regulates | phenotype | 0.80 |
| Nuclear TDP-43 Aggregation | mediates | phenotype | 0.80 |
| Cell-Cycle Regulation | involved_in | process | 0.75 |
| Source | Relation | Type | Str |
|---|---|---|---|
| G3BP1 | mediates | entity | 0.95 |
| HNRNPA2B1 | involved_in | protein | 0.95 |
| Alpha-Synuclein | involved_in | protein | 0.95 |
| G3BP1 | mediates | protein | 0.95 |
| Stress Granules | involved_in | process | 0.95 |
| TDP43 | associated_with | protein | 0.95 |
| Hnrnpa2B1 | associated_with | protein | 0.95 |
| Tardbp | involved_in | protein | 0.95 |
| TRIAD3A | mediates | protein | 0.93 |
| Tardbp | mediates | protein | 0.90 |
| G3BP1 | involved_in | protein | 0.90 |
| TARDBP | involved_in | protein | 0.90 |
| TDP-43 Oligomerization | involved_in | process | 0.88 |
| G3BP1 Ubiquitination | inhibits | process | 0.85 |
| Phosphorylation | regulates | process | 0.85 |
| Chemical Modulators Of Phase Separation | modulates | compound | 0.85 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| HSPB1 Phosphorylation Mimetics to Promote Protective TDP-43 | 0.820 | neurodegeneration | What is the therapeutic window between i |
| p62 Liquid-Liquid Phase Separation Nucleates Cross-Organelle | 0.649 | neurodegeneration | How do different organelle-specific auto |
| Liquid-Liquid Phase Separation Modifier Therapy | 0.551 | neurodegeneration | Protein aggregation cross-seeding across |
| Liquid-Liquid Phase Separation (LLPS) Saturation Partitionin | 0.461 | neurodegeneration | What determines the spatial organization |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| G3BP1-mediated stress granule assembly via liquid-liquid phase separat | exploratory | 0.900 | 0.00 | eukaryotic cells | proposed | N/A | |
| G3BP1 intrinsically disordered region analysis and phosphorylation eff | exploratory | 0.850 | 0.00 | in vitro protein analysis syst | proposed | N/A | |
| G3BP1-binding factor cooperativity in stress granule network regulatio | exploratory | 0.800 | 0.00 | cell culture systems with prot | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Pharmacological modulation of stress granules via G3BP1/2: A pathway to treat ca [PMID:41924133] | Yang J, Gao F | Front Pharmacol | 2026 | 0 |
| Stress granules at the crossroads of retroviral replication and antiviral immuni [PMID:41931190] | Akbarin MM, Farjami Z, Álvarez HR | Mol Biol Rep | 2026 | 0 |
| Pharmacological modulation of stress granules via G3BP1/2: A pathway to treat ca [PMID:41924133] | Yang J, Gao F | Frontiers in pharmacology | 2026 | 0 |
| Disruption of G3BP1 granules promotes mammalian CNS and PNS axon regeneration. [PMID:40014573] | ["Sahoo P", "Agrawal M", "Hanovice N", " | Proceedings of the National Ac | 2025 | 0 |
| β-propeller protein-associated neurodegeneration protein WDR45 regulates stress [PMID:40473629] | ["Li Y", "Fang J", "Ding Y", "Zhang X", | Nature communications | 2025 | 0 |
| Identification of small molecule inhibitors of G3BP-driven stress granule format [PMID:38284934] | ["Freibaum B", "Messing J", "Nakamura H" | The Journal of cell biology | 2024 | 0 |
| Stress granule formation helps to mitigate neurodegeneration. [PMID:39106168] | Glineburg MR, Yildirim E, Gomez N, Rodri | Nucleic acids research | 2024 | 0 |
| [WALANT - Wide Awake Local Anaesthesia No Tourniquet: Complications in elective [PMID:35168268] | Wieschollek S, Forster S, Megerle K | Handchirurgie, Mikrochirurgie, | 2022 | 0 |
| Future rice farming threatened by drought in the Lower Mekong Basin. [PMID:33931657] | Kang H, Sridhar V, Mainuddin M, Trung LD | Scientific reports | 2021 | 0 |
| Engineering complex communities by directed evolution. [PMID:33986540] | Chang CY, Vila JCC, Bender M, Li R, Mank | Nature ecology & evolution | 2021 | 0 |
| Sex differences in myelin content of white matter tracts in adolescents with dep [PMID:34215842] | Ho TC, Sisk LM, Kulla A, Teresi GI, Hans | Neuropsychopharmacology : offi | 2021 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning LIQUID-LIQUID PHASE SEPARATION in their description or question text
No additional research found