concept

HERV-K

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HERV-K: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

51Connections

0Hypotheses

0Analyses

38Outgoing

13Incoming

0Experiments

0Debates

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💡 Concept Info

Name	HERV-K
Key Genes/Proteins	Actin, AGING, ALS, AMYOTROPHIC LATERAL SCLEROSIS, DNA, INFLAMMATION
Related Diseases	Aging, Als, Amyotrophic Lateral Sclerosis, Dendritic Spine Abnormalities, Inflammation
Related Pathways	Dendritic Spine

Pathway Diagram

graph TD
    HERV_K["HERV-K"]
    HERV_K -->|"expressed in"| Cortical_Neurons["Cortical Neurons"]
    HERV_K -->|"expressed in"| Spinal_Neurons["Spinal Neurons"]
    HERV_K -->|"contributes to"| Neurodegeneration["Neurodegeneration"]
    HERV_K -->|"causes"| Motor_Dysfunction["Motor Dysfunction"]
    HERV_K -->|"causes"| Motor_Cortex_Volume_Loss["Motor Cortex Volume Loss"]
    HERV_K -->|"causes"| Dendritic_Spine_Abnormalities["Dendritic Spine Abnormalities"]
    HERV_K -->|"causes"| DNA_Damage["DNA Damage"]
    HERV_K -->|"causes"| Synaptic_Activity_Decrease["Synaptic Activity Decrease"]
    TDP43["TDP43"] -->|"regulates"| HERV_K
    NEURODEGENERATION["NEURODEGENERATION"] -->|"contributes to"| HERV_K
    DNA["DNA"] -->|"interacts"| HERV_K
    AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"] -->|"activates"| HERV_K
    NEURON["NEURON"] -->|"expressed in"| HERV_K
    ALS["ALS"] -->|"contributes to"| HERV_K
    TDP_43["TDP-43"] -->|"interacts"| HERV_K

Outgoing (38)

Target	Relation	Type	Str
Spinal Neurons	expressed_in	cell_type	0.90
Cortical Neurons	expressed_in	cell_type	0.90
Amyotrophic Lateral Sclerosis	associated_with	disease	0.90
Neurodegeneration	contributes_to	process	0.85
Motor Dysfunction	causes	phenotype	0.85
DNA Damage	causes	process	0.80
Synaptic Activity Decrease	causes	phenotype	0.80
Motor Cortex Volume Loss	causes	phenotype	0.80
Dendritic Spine Abnormalities	causes	phenotype	0.80
Muscle Atrophy	causes	phenotype	0.75
Neurodegeneration	interacts_with	disease	0.65
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Aging	interacts_with	disease	0.65
Inflammation	interacts_with	disease	0.65
Als	contributes_to	disease	0.65
Neurodegeneration	contributes_to	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Actin	interacts_with	protein	0.60
NEURON	expressed_in	gene	0.60
ALS	contributes_to	gene	0.60
Dendritic Spine	expressed_in	pathway	0.60
NEURODEGENERATIVE DISORDERS	interacts_with	gene	0.60
Tdp-43	interacts_with	pathway	0.60
TDP-43	interacts_with	gene	0.60
Pyramidal	expressed_in	cell_type	0.60
RNA	interacts_with	gene	0.60
ALS	interacts_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	0.60
DNA	interacts_with	gene	0.60
NEURODEGENERATION	contributes_to	gene	0.60
INFLAMMATION	interacts_with	gene	0.60
NEURODEGENERATION	interacts_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	interacts_with	gene	0.60
AGING	interacts_with	gene	0.60
Neuron	expressed_in	cell_type	0.55
Spinal Cord	expressed_in	brain_region	0.55
Cortex	expressed_in	brain_region	0.55

Incoming (13)

Source	Relation	Type	Str
TDP43	regulates	protein	0.85
NEURODEGENERATION	contributes_to	gene	0.60
DNA	interacts_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	0.60
NEURON	expressed_in	gene	0.60
ALS	contributes_to	gene	0.60
ALS	interacts_with	gene	0.60
TDP-43	interacts_with	gene	0.60
RNA	interacts_with	gene	0.60
AGING	interacts_with	gene	0.60
NEURODEGENERATION	interacts_with	gene	0.60
INFLAMMATION	interacts_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HERV-K in their description or question text

No additional research found