gene

STMN2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about STMN2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

119Connections

1Hypotheses

1Analyses

50Outgoing

40Incoming

0Experiments

1Debates

Summary

STMN2 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, regulates, activates. Associated with Als, Amyotrophic Lateral Sclerosis, Ms. Connected to 22 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	STMN2
Chromosome	8q21.13
Function	Like other stathmin family members, it can sequester tubulin dimers, reducing the pool of free tubulin available for microtubule polymerization.
Primary Expression	Motor Neurons, Cortical Neurons, Sensory Neurons, Developing CNS
Subcellular Localization	STMN2 exhibits a distinctive subcellular distribution:
Molecular Weight	20 kDa
Pathways	Axonal Regeneration
Ensembl ID	ENSG00000104435
GeneCards	STMN2
Human Protein Atlas	STMN2
Growth cones	High concentration at distal axons during development
Synaptic terminals	Enriched in presynaptic compartments
Axon initial segment	Localized at the boundary between soma and axon
Membrane association	Via N-terminal myristoylation and polybasic region
Associated Diseases	ALS, frontotemporal dementia, neurodegeneration
Interactions	Actin, ALS, AMYOTROPHIC LATERAL SCLEROSIS, AND, ATP, AXON REGENERATION
SciDEX Hypotheses	STMN2 Restoration as a Prerequisite for Axon Growt
KG Connections	119 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    STMN2["STMN2"]
    Als{"Als"}
    STMN2 -->|"interacts with"| Als
    Ms{"Ms"}
    STMN2 -->|"interacts with"| Ms
    Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
    STMN2 -->|"interacts with"| Amyotrophic_Lateral_Sclerosis
    STMN2 -->|"regulates"| Als
    Neuropathy{"Neuropathy"}
    STMN2 -->|"regulates"| Neuropathy
    STMN2 -->|"regulates"| Amyotrophic_Lateral_Sclerosis
    AXONAL_REGENERATION["AXONAL_REGENERATION"]
    STMN2 -->|"activates"| AXONAL_REGENERATION
    ALS["ALS"]
    STMN2 -->|"interacts with"| ALS
    Mitochondrial_Function(["Mitochondrial Function"])
    STMN2 -->|"interacts with"| Mitochondrial_Function
    STMN2 -->|"regulates"| ALS
    NEURODEGENERATION["NEURODEGENERATION"]
    STMN2 -->|"associated with"| NEURODEGENERATION
    neurodegeneration["neurodegeneration"]
    STMN2 -->|"implicated in"| neurodegeneration
    TDP43["TDP43"]
    TDP43 -->|"regulates"| STMN2
    POLYADENYLATION["POLYADENYLATION"]
    POLYADENYLATION -->|"inhibits"| STMN2
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    NEURODEGENERATIVE_DISEASES -->|"interacts with"| STMN2
    FTLD["FTLD"]
    FTLD -->|"interacts with"| STMN2
    C9ORF72["C9ORF72"]
    C9ORF72 -->|"interacts with"| STMN2
    NEFL["NEFL"]
    NEFL -->|"activates"| STMN2
    AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"]
    AMYOTROPHIC_LATERAL_SCLEROSIS -->|"interacts with"| STMN2
    MOTOR_NEURONS["MOTOR NEURONS"]
    MOTOR_NEURONS -->|"regulates"| STMN2
    AMYOTROPHIC_LATERAL_SCLEROSIS -->|"regulates"| STMN2
    AXON_REGENERATION["AXON REGENERATION"]
    AXON_REGENERATION -->|"activates"| STMN2
    style STMN2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (79)

Target	Relation	Type	Str
Axonal Outgrowth	mediates	phenotype	0.90
Axonal Regeneration	involved_in	process	0.90
Axonal Regeneration	mediates	process	0.90
Motor Neuron Growth	mediates	phenotype	0.90
Axon Regeneration	mediates	phenotype	0.90
TDP-43 Pathology	biomarker_for	phenotype	0.88
Stress	downregulates	phenotype	0.88
Lysosome Trafficking	regulates	process	0.85
Microtubule Regulation	involved_in	process	0.85
Motor Neurons	expressed_in	cell_type	0.85
TDP-43	regulates	protein	0.80
neurons	expressed_in	cell_type	0.75
neurodegeneration	associated_with	disease	0.66
Neuropathy	regulates	disease	0.65
Amyotrophic Lateral Sclerosis	regulates	disease	0.65
Als	regulates	disease	0.65
Aging	interacts_with	disease	0.65
Als	expressed_in	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.65
UNC13A	targets	gene	0.65
Als	activates	disease	0.65
Ms	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
AXONAL_REGENERATION	activates	phenotype	0.64
TDP-43	interacts_with	gene	0.60
CHMP7	expressed_in	gene	0.60
TDP-43	activates	gene	0.60
frontotemporal dementia	associated_with	disease	0.60
RNA	associated_with	gene	0.60
ALS	activates	gene	0.60
Neuron	activates	cell_type	0.60
RNA	interacts_with	gene	0.60
NEURON	interacts_with	gene	0.60
Stem Cell	interacts_with	cell_type	0.60
Neuron	interacts_with	cell_type	0.60
RNA SPLICING	interacts_with	gene	0.60
stem cells	expressed_in	cell_type	0.60
oxidative stress response	participates_in	pathway	0.60
SMN	interacts_with	gene	0.60
Rb	interacts_with	protein	0.60
ALS	associated_with	disease	0.60
Alzheimer's disease	targets	disease	0.60
UNC13A	co_expressed_with	gene	0.60
UNC13A	inhibits	gene	0.60
neurodegeneration	targets	disease	0.60
ALS	interacts_with	gene	0.60
Mitochondrial Function	interacts_with	pathway	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
Er Stress	activates	pathway	0.60

Incoming (40)

Source	Relation	Type	Str
TARDBP	regulates	protein	0.95
TDP-43	regulates	protein	0.90
Stress	downregulates	process	0.90
TDP43	binds	protein	0.90
Premature Polyadenylation	downregulates	mechanism	0.90
Reduced TDP43	downregulates	biomarker	0.90
TDP-43	binds	protein	0.90
dCasRx	targets	protein	0.80
TDP43	regulates	protein	0.72
POLYADENYLATION	inhibits	phenotype	0.64
TDP-43	interacts_with	gene	0.60
CHMP7	expressed_in	gene	0.60
SMD1	expressed_in	gene	0.60
RNA	associated_with	gene	0.60
SMN	interacts_with	gene	0.60
C9ORF72	interacts_with	gene	0.60
NEFL	activates	gene	0.60
MOTOR NEURONS	regulates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	regulates	gene	0.60
AXON REGENERATION	activates	gene	0.60
RNA	inhibits	gene	0.60
FTLD	regulates	gene	0.60
ATP	activates	gene	0.60
ALS	activates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	0.60
AND	activates	gene	0.60
ALS	expressed_in	gene	0.60
NEURON	interacts_with	gene	0.60
MOTOR NEURONS	interacts_with	gene	0.60
AND	expressed_in	gene	0.60
ALS	associated_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	interacts_with	gene	0.60
NEURODEGENERATIVE DISEASES	interacts_with	gene	0.60
FTLD	interacts_with	gene	0.60
ALS	regulates	gene	0.55
ALS	biomarker_for	gene	0.55
ALS	targets	gene	0.55
RNA	targets	gene	0.55
MAPT	associated_with	gene	0.55
CHMP7	co_expressed_with	gene	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
STMN2 Restoration as a Prerequisite for Axon Growth After TD	0.683	neurodegeneration	What molecular mechanisms enable functio

Mentioning Analyses (1)

Scientific analyses that reference this entity

What molecular mechanisms enable functional recovery and muscle re-innervation a

neurodegeneration | 2026-04-14 | 2 hypotheses Top: 0.683

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The study shows dramatic functional recovery and muscle re-innervation after cyt

closed · Rounds: 4 · Score: 0.85 · 2026-04-15

Related Research

Hypotheses and analyses mentioning STMN2 in their description or question text

No additional research found