| Gene Symbol | TARDBP |
| Aliases | TAR DNA-binding protein 43 |
| Chromosome | 1p36.2 |
| Protein Family | Heterogeneous nuclear ribonucleoprotein (hnRNP) family |
| Function | is a highly conserved RNA/DNA-binding protein encoded by the TARDBP gene on chromosome 1p36. |
| Primary Expression | Nucleus (physiological), cytoplasm (disease) |
| Molecular Weight | 43 kDa (414 amino acids) |
| Amino Acids | 414 aa |
| Exons | 2 |
| Pathways | RNA metabolism, Stress granules, Protein aggregation |
| UniProt ID | Q13148 |
| GeneCards | TARDBP |
| Human Protein Atlas | TARDBP |
| Protein dimerization | The NTD mediates homodimer formation, essential for functional activity[@chang2019] |
| Nuclear localization | Contains a basic nuclear localization signal (NLS, residues 82-98) |
| Associated Diseases | Als, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis, Dementia |
| Interactions | Actin, AKT, ALS, amyotrophic lateral sclerosis, AMYOTROPHIC LATERAL SCLEROSIS, ATXN2 |
| KG Connections | 244 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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