concept

PINK

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PINK: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

49Connections

10Hypotheses

2Analyses

26Outgoing

23Incoming

1Experiments

2Debates

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💡 Concept Info

Name	PINK
Key Genes/Proteins	6-OHDA, AND, ATP13A2, CHCHD10, CHCHD2, DJ-1
Related Diseases	ALS, AMYLOID, autism spectrum disorder, diabetes
Linked Hypotheses	15 hypotheses

Wiki Pages (16)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    PINK["PINK"]
    PINK -->|"expressed in"| Parkinson["Parkinson"]
    PINK -->|"activates"| ALS["ALS"]
    PINK -->|"expressed in"| PRKN["PRKN"]
    PINK -->|"expressed in"| GAIN["GAIN"]
    PINK -->|"expressed in"| AND["AND"]
    PINK -->|"expressed in"| PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PINK -->|"expressed in"| PARKINSON["PARKINSON"]
    PRKN -->|"expressed in"| PINK
    PINK1["PINK1"] -->|"expressed in"| PINK
    LRRK2["LRRK2"] -->|"expressed in"| PINK
    PARKINSON -->|"expressed in"| PINK
    ATP13A2["ATP13A2"] -->|"expressed in"| PINK
    GAIN -->|"expressed in"| PINK
    DJ_1["DJ-1"] -->|"expressed in"| PINK
    AND -->|"expressed in"| PINK

Outgoing (26)

Target	Relation	Type	Str
Parkinson	activates	disease	0.65
Parkinson	expressed_in	disease	0.65
ALS	activates	disease	0.65
PARKINSON	expressed_in	gene	0.60
GAIN	expressed_in	gene	0.60
AND	expressed_in	gene	0.60
PARKINSON'S DISEASE	expressed_in	gene	0.60
PRKN	expressed_in	gene	0.60
autism spectrum disorder	activates	disease	0.60
6-OHDA	activates	gene	0.60
AND	activates	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
PARKINSON	activates	gene	0.60
PTEN	activates	gene	0.60
Parkinson's disease	activates	disease	0.60
TNF	activates	gene	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
pyroptosis	participates_in	pathway	0.60
diabetes	activates	disease	0.60
TDP43	interacts_with	gene	0.60
ALS	interacts_with	disease	0.60
neurons	expressed_in	cell_type	0.55
Neuron	expressed_in	cell_type	0.55
Stem Cell	expressed_in	cell_type	0.55
Substantia Nigra	expressed_in	brain_region	0.55

Incoming (23)

Source	Relation	Type	Str
AMYLOID	associated_with	disease	0.80
NLRP3	activates	gene	0.60
IR	activates	gene	0.60
metformin	targets	drug	0.60
GENES	activates	gene	0.60
PARKINSON	activates	gene	0.60
LRRK2	activates	gene	0.60
DJ-1	activates	gene	0.60
PARKIN	activates	gene	0.60
AND	activates	gene	0.60
6-OHDA	activates	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
PRKN	expressed_in	gene	0.60
PINK1	expressed_in	gene	0.60
LRRK2	expressed_in	gene	0.60
PARKINSON	expressed_in	gene	0.60
ATP13A2	expressed_in	gene	0.60
GAIN	expressed_in	gene	0.60
DJ-1	expressed_in	gene	0.60
AND	expressed_in	gene	0.60
PARKINSON'S DISEASE	expressed_in	gene	0.60
CHCHD10	interacts_with	gene	0.60
CHCHD2	interacts_with	gene	0.60

Targeting Hypotheses (10)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK	0.738	Alzheimer's Disease	Cell type vulnerability in Alzheimers Di
OPTN/TBK1 mutations create selective vulnerability by blocki	0.670	neurodegeneration	What are the neuron-specific effects of
Dose-Response Framework: PINK1/Parkin Mitophagy as the Criti	0.614	neurodegeneration	View
Mitophagy collapse via PINK1-PRKN is the primary autophagy l	0.614	neurodegeneration	What specific autophagy pathways are def
PINK1/PARK2-Mediated Mitophagy Enhancement for Neuroinflamma	0.571	Neuroinflammation	Immune atlas neuroinflammation analysis

TRPML1-PINK1/Parkin Axis Coordinates Mitophagy with Lysosoma	0.560	neurodegeneration	Does TRPML1 enhancement cause therapeuti
PINK1/Parkin-Independent Mitophagy Bypass for Enhanced Donor	0.529	neurodegeneration	Mitochondrial transfer between neurons a
Mitochondrial-Targeted PINK1/Parkin Pathway Activation for N	0.500	neurodegeneration	Test Hypothesis Fixtures
PINK1/PARK2-LC3 Mitophagy Enhancement	0.485	Neuroinflammation	Immune atlas neuroinflammation analysis
Combination Gene Therapy Targeting RGS6 and Parkin or PINK1	0.317	neurodegeneration	Does RGS6 upregulation or D2 autorecepto

Mentioning Analyses (2)

Scientific analyses that reference this entity

Do PINK1/PARKIN pathway enhancements rescue excitatory neuron vulnerability or c

neurodegeneration | 2026-04-11 | 0 hypotheses

Do PINK1/PARKIN pathway enhancements rescue excitatory neuron vulnerability or e

neurodegeneration | 2026-04-11 | 0 hypotheses

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
iPSC-derived astrocyte-neuron co-culture mitochondrial transfer in PD	exploratory	Parkinson's disease	0.900	0.00	iPSC-derived dopaminergic neur	proposed	N/A

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Transcriptomic cytoarchitecture reveals principles of human neocortex organizati [PMID:37824655]	Jorstad NL, Close J, Johansen N, Yanny A	Science	2023	186
Targeted nanovesicular delivery of dexmedetomidine modulates microglial lysosoma [PMID:41778730]	Zhang Y, Jiang H, Zhang F, Liao J	Neural regeneration research	2026	0
The myocardial ischemic cascade network and multi-target synergistic interventio [PMID:41544859]	Qi L, Yi J, Shen Y, Jiang H, Yao X et al	Biochem Pharmacol	2026	0
Homoplantaginin ameliorates osteoarthritis by activating Sirt3/PINK1/Parkin sign [PMID:41720004]	Zhang H, Xiao J, Yi Y, Chen B, Lv W et a	Phytomedicine	2026	0
Kakkalide promotes spinal cord injury repair by regulating microglial M2 polariz [PMID:41720005]	You T, Dai B, Ding X, He Z, Peng J et al	Phytomedicine	2026	0
Interaction of mtROS-Immune-Inflammatory Vicious Cycle Activation in Sepsis-Indu [PMID:41905969]	Wang Y, Yuan Q	Clin Exp Pharmacol Physiol	2026	0
Metformin attenuates HSV-1-induced neuropathic pain by restoring Sirt3-mediated [PMID:41896899]	Yuanyuan Fang; Mengqiu Deng; Kesheng Hua	Cell communication and signali	2026	0
Hydrogen-Enriched Hyaluronic Acid Dressing Ameliorates Diabetic Foot Ulcer via P [PMID:41906653]	Xu Z, Cui X, Chu H, Wan H, Xie Y, Wang Y	Journal of diabetes	2026	0
SIRT1 activation by SRT2104 enhances mitophagy and reduces senescence in auditor [PMID:41593189]	["Cho S", "Jo E", "Jang H"]	Scientific reports	2026	0
Inhibition of mitochondrial ROS turns LC3-associated phagocytosis to autophagy u [PMID:41896101]	Cheng YL, Su MS, Liao CC, Chang TW, Hsie	Journal of microbiology, immun	2026	0
Hyperoside stabilizes ACAT1 to promote fatty acid oxidation and attenuate kidney [PMID:41903436]	Shan C, Szili-Torok T, Yue G, Zhang L, M	Phytomedicine : international	2026	0
Melatonin Ameliorates decaBDE-Induced Autism-Relevant Behaviors Through Promotin [PMID:41897550]	["Gao L", "Shen J", "Gao J", "Li T", "Ya	Antioxidants (Basel, Switzerla	2026	0
Sirtuins as mediators and targets of arsenic toxicity: unraveling signaling path [PMID:40844627]	El-Mahrouk SR, El-Kadi AOS	Archives of toxicology	2025	0
Comprehensive Insights Into Mitophagy: Mechanisms, Disease Associations, and The [PMID:40714832]	["Tang M", "Outissint I", "Chen Y", "Gon	Journal of cellular biochemist	2025	0
Targeted activation of ErbB4 receptor ameliorates neuronal deficits and neuroinf [PMID:40089796]	Liu C, Zhao Y, Zhang W, Dao JJ, Li Q, Hu	Journal of neuroinflammation	2025	0
Phenylpropanoids of Eleutherococcus senticosus (Rupr. & maxim.) maxim. Alleviate [PMID:40081261]	Yang R, Meng X, Zhao W, Xu SQ, Wang SY,	Bioorganic chemistry	2025	0
Small molecule DDQ involvement of ERK-mediated signaling pathway with enhanced m [PMID:40222458]	Pradeepkiran JA, Kshirsagar S, Alvir RV,	Biochimica et biophysica acta.	2025	0
The effects of Honokiol on the liver of Alzheimer's disease mice by upregulating [PMID:40776632]	Wang H, Liu J, Tian YR, Zhu F, Li H	Journal of Alzheimer's disease	2025	0
Identification of mitophagy-associated proteins profile as potential plasma biom [PMID:37990436]	["Qian S", "He H", "Xiong X", "Ai R", "W	CNS neuroscience & therapeutic	2024	0
Dimethyl Fumarate Exerts a Neuroprotective Effect by Enhancing Mitophagy via the [PMID:38405353]	["Pinjala P", "Tryphena K", "Kulkarni A"	Journal of Alzheimer's disease	2024	0

Debates (2)

Multi-agent debates referencing this entity

The debate revealed a critical gap: while PINK1/PARKIN deficiency correlates wit

closed · Rounds: 4 · Score: 0.50 · 2026-04-20

The debate revealed a critical gap: while excitatory neurons show mitochondrial

closed · Rounds: 4 · Score: 0.50 · 2026-04-20

Related Research

Hypotheses and analyses mentioning PINK in their description or question text

TRPML1-PINK1/Parkin Axis Coordinates Mitophagy with Lysosomal Biogenesis

Score: 0.560 · neurodegeneration · 2026-04-16

## Mechanistic Overview TRPML1-PINK1/Parkin Axis Coordinates Mitophagy with Lysosomal Biogenesis starts from the claim t

PINK1/Parkin-Independent Mitophagy Bypass for Enhanced Donor Mitochondria

Score: 0.529 · neurodegeneration · 2026-04-02

Inhibition of alternative mitophagy pathways (BNIP3/NIX) in healthy donor cells prevents degradation of transferable mit

Mitochondrial-Targeted PINK1/Parkin Pathway Activation for Neuroprotection

Score: 0.500 · neurodegeneration · 2026-04-26

PINK1 loss-of-function prevents Parkin recruitment to damaged mitochondria, blocking mitophagy. Urolithin A is proposed

PINK1/PARK2-LC3 Mitophagy Enhancement

Score: 0.485 · Neuroinflammation · 2026-04-21

## Mechanistic Overview PINK1/PARK2-LC3 Mitophagy Enhancement starts from the claim that modulating PINK1 within the dis

Combination Gene Therapy Targeting RGS6 and Parkin or PINK1 to Address Mitochond

Score: 0.317 · neurodegeneration · 2026-04-18

## Mechanistic Overview Combination Gene Therapy Targeting RGS6 and Parkin or PINK1 to Address Mitochondrial Dysfunction

PINK

Understanding Entity Pages

Wiki Pages (16)

PINK1-Parkin Mitophagy Pathway in Parkinson's Disease

PINK1-Parkin Mitophagy Complex

Mitophagy Gate Therapy: PINK1/Parkin + TFEB Priming

PINK1-Deficient Dopaminergic Neurons

PINK1 Activators for Parkinson's Disease

PINK1/PARKIN Mitophagy Activators for Parkinson's Disease

PINK1-Parkin Mitophagy Activators

PINK1 Protein

PINK1 — PTEN Induced Kinase 1

PINK1

PINK1-Deficient Dopamine Neurons

PINK1/Parkin Pathway in Parkinson's Disease

PINK1/Parkin Activators

PINK1 (PTEN-Induced Kinase 1)