gene

PABPN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PABPN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

7Connections

0Hypotheses

0Analyses

4Outgoing

3Incoming

0Experiments

0Debates

Summary

Page for PABPN1

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🧬 Gene Info

Gene Symbol	PABPN1
Chromosome	14q11.2
Function	It interacts with the cleavage and polyadenylation specificity factor (CPSF) complex to ensure proper 3'-end processing of pre-mRNA [1].
Molecular Weight	33 kDa
Amino Acids	306 aa
Exons	17
Pathways	Proteasome, Ubiquitin-Proteasome
Ensembl ID	ENSG00000122591
GeneCards	PABPN1
Human Protein Atlas	PABPN1
mRNA Export	The protein facilitates mRNA export from the nucleus to the cytoplasm by interacting with export receptors. This function is crucial for delivering processed mRNAs to ribosomes for translation [2].
Translation Regulation	PABPN1 modulates translation efficiency through its interaction with translation initiation factors. It can either enhance or repress translation depending on the mRNA context and cellular state.
mRNA Stability	By protecting poly(A) tails from deadenylation, PABPN1 contributes to mRNA stability and half-life. This function is particularly important for long-lived mRNAs involved in cellular homeostasis.
RNA Recognition Motif (RRM)	Located at the N-terminus, mediates RNA binding
Glycine-rich domain	Involved in protein-protein interactions
Associated Diseases	Als
Interactions	GAIN, HSP70, TDP43
KG Connections	7 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

PABPN1

gene · 2110 words

→

PABPN1 Protein

protein · 1200 words

→

Pathway Diagram

graph TD
    PABPN1["PABPN1"]
    Ms{"Ms"}
    PABPN1 -->|"activates"| Ms
    Als{"Als"}
    PABPN1 -->|"associated with"| Als
    Ubiquitin_Proteasome(["Ubiquitin-Proteasome"])
    PABPN1 -->|"activates"| Ubiquitin_Proteasome
    Proteasome(["Proteasome"])
    PABPN1 -->|"activates"| Proteasome
    neurodegeneration["neurodegeneration"]
    PABPN1 -->|"implicated in"| neurodegeneration
    HSP70["HSP70"]
    HSP70 -->|"activates"| PABPN1
    GAIN["GAIN"]
    GAIN -->|"activates"| PABPN1
    style PABPN1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (4)

Target	Relation	Type	Str
Ms	activates	disease	0.65
Als	associated_with	disease	0.65
Ubiquitin-Proteasome	activates	pathway	0.60
Proteasome	activates	pathway	0.60

Incoming (3)

Source	Relation	Type	Str
TDP43	interacts_with	protein	0.80
HSP70	activates	gene	0.60
GAIN	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PABPN1 in their description or question text

No additional research found