concept

PPM1D

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PPM1D: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

76Connections

0Hypotheses

0Analyses

50Outgoing

23Incoming

0Experiments

0Debates

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💡 Concept Info

Name	PPM1D
Key Genes/Proteins	AIM2, ALZHEIMER, ALZHEIMER'S DISEASE, AND, APOPTOSIS, ASXL1
Related Diseases	Als, Alzheimer, Cancer, Cardiovascular
Related Pathways	Apoptosis, Cgas-Sting

Pathway Diagram

graph TD
    PPM1D["PPM1D"]
    PPM1D -->|"regulates"| Chronic_Inflammation["Chronic Inflammation"]
    PPM1D -->|"contributes to"| Clonal_Hematopoiesis["Clonal Hematopoiesis"]
    PPM1D -->|"target for"| Cardiovascular["Cardiovascular"]
    PPM1D -->|"target for"| Cancer["Cancer"]
    PPM1D -->|"activates"| Inflammation["Inflammation"]
    PPM1D -->|"target for"| Alzheimer["Alzheimer"]
    PPM1D -->|"target for"| Heart_Failure["Heart Failure"]
    ALZHEIMER["ALZHEIMER"] -->|"target for"| PPM1D
    GENES["GENES"] -->|"activates"| PPM1D
    CANCER["CANCER"] -->|"target for"| PPM1D
    TET2["TET2"] -->|"activates"| PPM1D
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"target for"| PPM1D
    SF3B1["SF3B1"] -->|"activates"| PPM1D
    ASXL1["ASXL1"] -->|"activates"| PPM1D
    U2AF1["U2AF1"] -->|"activates"| PPM1D

Outgoing (53)

Target	Relation	Type	Str
Chronic Inflammation	regulates	process	0.85
DNA damage response	regulates	process	0.82
Chronic Inflammation	promotes	process	0.80
Immune Responses	modifies	process	0.80
Clonal Hematopoiesis	contributes_to	biological_process	0.80
Senescence	contributes_to	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Heart Failure	therapeutic_target	disease	0.65
Inflammation	activates	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Als	contributes_to	disease	0.65
Heart Failure	activates	disease	0.65
Alzheimer	activates	disease	0.65
Cardiovascular	activates	disease	0.65
Cancer	activates	disease	0.65
Stem Cell	therapeutic_target	cell_type	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
SF3B1	activates	gene	0.60
Microglia	therapeutic_target	cell_type	0.60
U2AF1	activates	gene	0.60
CANCER	activates	gene	0.60
Inflammasome	contributes_to	pathway	0.60
Er Stress	contributes_to	pathway	0.60
Apoptosis	contributes_to	pathway	0.60
Neuron	contributes_to	cell_type	0.60
FANCE	interacts_with	gene	0.60
INFLAMMATION	activates	gene	0.60
TP53	activates	gene	0.60
DNMT3A	activates	gene	0.60
Epigenetic	activates	pathway	0.60
Immune Response	activates	pathway	0.60
AND	activates	gene	0.60
AIM2	contributes_to	gene	0.60
ATR	interacts_with	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
DNA	activates	gene	0.60
TET2	activates	gene	0.60
P53	activates	protein	0.60
ASXL1	activates	gene	0.60
Rb	therapeutic_target	protein	0.60
epigenetic regulation	participates_in	pathway	0.60
ATM	interacts_with	gene	0.60
DNA	interacts_with	gene	0.60
FANCC	interacts_with	gene	0.60
APOPTOSIS	contributes_to	gene	0.60
P53	interacts_with	gene	0.60
CGAS-STING	contributes_to	gene	0.60
Dna Repair	interacts_with	pathway	0.60
Cgas-Sting	contributes_to	pathway	0.60

Incoming (23)

Source	Relation	Type	Str
ATR	interacts_with	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
GENES	activates	gene	0.60
CANCER	therapeutic_target	gene	0.60
TET2	activates	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
SF3B1	activates	gene	0.60
ASXL1	activates	gene	0.60
U2AF1	activates	gene	0.60
DNA	activates	gene	0.60
TP53	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
DNMT3A	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
AND	activates	gene	0.60
FANCC	interacts_with	gene	0.60
APOPTOSIS	contributes_to	gene	0.60
ATM	interacts_with	gene	0.60
FANCA	interacts_with	gene	0.60
DNA	interacts_with	gene	0.60
CGAS-STING	contributes_to	gene	0.60
FANCI	interacts_with	gene	0.60
P53	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PPM1D in their description or question text

No additional research found