Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CDKL5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | CDKL5 |
| Full Name | Cyclin-Dependent Kinase-Like 5 |
| Chromosome | Xp22.13 |
| Protein Family | CDK family (CDK1-18), MAPK/CDK group |
| Protein Type | Kinase |
| Function | encodes a serine-threonine kinase expressed predominantly in the developing brain, particularly in neurons. |
| Primary Expression | Brain (neurons, high in cortex, hippocampus, cerebellum); low elsewhere |
| Molecular Weight | 145 kDa |
| Amino Acids | 075 aa |
| Pathways | MAPK |
| UniProt ID | Q6VAC4 |
| NCBI Gene ID | 6792 |
| Ensembl ID | ENSG00000008086 |
| OMIM | 300203 |
| GeneCards | CDKL5 |
| Human Protein Atlas | CDKL5 |
| Associated Diseases | neurodegeneration |
| Interactions | APOPTOSIS, ERK |
| KG Connections | 16 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
CDKL5["CDKL5"]
Als{"Als"}
CDKL5 -->|"activates"| Als
ERK["ERK"]
CDKL5 -->|"activates"| ERK
Neurogenesis(["Neurogenesis"])
CDKL5 -->|"activates"| Neurogenesis
Apoptosis(["Apoptosis"])
CDKL5 -->|"activates"| Apoptosis
AND["AND"]
CDKL5 -->|"activates"| AND
neurodegeneration["neurodegeneration"]
CDKL5 -->|"implicated in"| neurodegeneration
GENES["GENES"]
GENES -->|"contributes to"| CDKL5
APOPTOSIS["APOPTOSIS"]
APOPTOSIS -->|"activates"| CDKL5
ERK -->|"activates"| CDKL5
style CDKL5 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Als | activates | disease | 0.65 |
| ERK | activates | gene | 0.60 |
| Neurogenesis | activates | pathway | 0.60 |
| Apoptosis | activates | pathway | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| HCN1 | associated_with | gene | 0.60 |
| KCNQ2 | associated_with | gene | 0.60 |
| PLCB1 | associated_with | gene | 0.60 |
| SCN1A | associated_with | gene | 0.60 |
| SCN2A | associated_with | gene | 0.60 |
| SCN8A | associated_with | gene | 0.60 |
| STXBP1 | associated_with | gene | 0.60 |
| WWOX | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning CDKL5 in their description or question text
No additional research found