Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about STXBP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
STXBP1 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, inhibits, implicated in. Associated with Aging, Als, Ms. Connected to 12 entities in the SciDEX knowledge graph.
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| Gene Symbol | STXBP1 |
| Full Name | Munc18-1 |
| Protein Type | Protein |
| Function | is a neuronal protein essential for synaptic vesicle release and neurotransmitter secretion. |
| Primary Expression | non-neuronal tissues, important for immune function |
| Molecular Weight | 66 kDa |
| Amino Acids | 594 aa |
| UniProt ID | Search UniProt |
| GeneCards | STXBP1 |
| Human Protein Atlas | STXBP1 |
| Domain 1a | N-terminal region that binds to the N-terminal peptide of syntaxin-1 |
| Domain 1b | Central region involved in regulatory interactions |
| Domain 2/3 | C-terminal region that forms a tight complex with full-length syntaxin-1 |
| Munc18-1 (STXBP1) | Neuron-specific isoform, most abundant in the brain |
| Munc18-2 (STXBP2) | Expressed in non-neuronal tissues, important for immune function |
| Associated Diseases | ALS, neurodegeneration |
| Interactions | AND, DNAJC5, ERK, GENES, HSC70, MUNC18-1 |
| KG Connections | 36 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
STXBP1["STXBP1"]
Aging{"Aging"}
STXBP1 -->|"therapeutic target"| Aging
Als{"Als"}
STXBP1 -->|"therapeutic target"| Als
Ms{"Ms"}
STXBP1 -->|"therapeutic target"| Ms
SYNGAP1["SYNGAP1"]
STXBP1 -->|"inhibits"| SYNGAP1
ERK["ERK"]
STXBP1 -->|"inhibits"| ERK
Epigenetic(["Epigenetic"])
STXBP1 -->|"therapeutic target"| Epigenetic
SCN1A["SCN1A"]
STXBP1 -->|"therapeutic target"| SCN1A
AND["AND"]
STXBP1 -->|"inhibits"| AND
neurodegeneration["neurodegeneration"]
STXBP1 -->|"implicated in"| neurodegeneration
SCN1A -->|"therapeutic target"| STXBP1
ERK -->|"inhibits"| STXBP1
RAS["RAS"]
RAS -->|"inhibits"| STXBP1
style STXBP1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Als | therapeutic_target | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| Aging | therapeutic_target | disease | 0.65 |
| ALS | interacts_with | disease | 0.65 |
| Neurodegeneration | interacts_with | disease | 0.65 |
| AND | interacts_with | gene | 0.60 |
| Chaperone | inhibits | pathway | 0.60 |
| SYNGAP1 | inhibits | gene | 0.60 |
| DNAJC5 | interacts_with | gene | 0.60 |
| Synaptic Vesicle | interacts_with | pathway | 0.60 |
| ALS | associated_with | disease | 0.60 |
| WWOX | associated_with | gene | 0.60 |
| ERK | inhibits | gene | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| Epigenetic | therapeutic_target | pathway | 0.60 |
| SCN1A | therapeutic_target | gene | 0.60 |
| neurodegeneration | associated_with | disease | 0.60 |
| Neuron | expressed_in | cell_type | 0.55 |
| SNAP-25 | interacts_with | protein | 0.50 |
| HSC70 | interacts_with | protein | 0.50 |
| MUNC18-1 | interacts_with | protein | 0.50 |
| Proteins | interacts_with | protein | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| NEURODEGENERATION | interacts_with | gene | 0.60 |
| GENES | interacts_with | gene | 0.60 |
| SCN1A | therapeutic_target | gene | 0.60 |
| SNARE | regulates | gene | 0.60 |
| CDKL5 | associated_with | gene | 0.60 |
| HCN1 | associated_with | gene | 0.60 |
| KCNQ2 | associated_with | gene | 0.60 |
| PLCB1 | associated_with | gene | 0.60 |
| SCN1A | associated_with | gene | 0.60 |
| SCN2A | associated_with | gene | 0.60 |
| SCN8A | associated_with | gene | 0.60 |
| ERK | inhibits | gene | 0.60 |
| RAS | inhibits | gene | 0.60 |
| DNAJC5 | co_expressed_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning STXBP1 in their description or question text
No additional research found