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protein 876 words KG: REELIN
Contents

Reelin Protein

🔬 Protein Info
Gene SymbolRELN
AliasesComprehensive page on Reelin
Chromosome7q22.1
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight388 kDa
Amino Acids460 aa
PathwaysDendritic Spine
UniProt IDP78536
NCBI Gene ID5649
GeneCardsRELN
Human Protein AtlasRELN
Associated DiseasesAging, Als, Alzheimer, Alzheimer's disease
InteractionsALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND, APOE3, APOER2
KG Connections312 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (16)

Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72Reelin-Mediated Cytoskeletal Stabilization Protocol
Score: 0.69Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79Competitive APOE4 Domain Stabilization Peptides
Score: 0.78APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76APOE Isoform Expression Across Glial Subtypes
Score: 0.74APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72APOE Isoform Conversion Therapy
Score: 0.72HCN1-Mediated Resonance Frequency Stabilization Therapy
Score: 0.65Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62LRP1-Dependent Tau Uptake Disruption
Score: 0.60Trans-Synaptic Adhesion Molecule Modulation
Score: 0.54

Related Analyses (9)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archivedAPOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archivedMitochondrial transfer between astrocytes and neurons
neurodegeneration · archivedTau propagation mechanisms and therapeutic interception poin
neurodegeneration · archivedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

Related Experiments (4)

Reelin pathway defects in human type 2 lissencephaly
exploratory · proposed · Score: 0.70Reelin glycoprotein treatment rescue experiment
validation · proposed · Score: 0.90Reelin treatment rescue via ApoER2 in CD2AP mutant mice
validation · proposed · Score: 0.87VE-cadherin control of reelin secretion in vitro and in vivo
exploratory · proposed · Score: 0.85

See Also (4)

Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: therapeutic_targetAPOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: associated_withAlzheimer Indonesia
institution · KG edge: associated_withAging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with

Knowledge Graph (12 edges)

DCX causes REELIN
DYNEIN causes REELIN
PAFAH1B1 causes REELIN
DAB1 causes REELIN
REST activates REELIN
CD2AP activates REELIN
JUN protects_against REELIN
APOE associated_with REELIN
RELN protects_against REELIN
CDK5 causes REELIN

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