Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RAB11B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
RAB11B is a gene implicated in neurodegeneration research. Key relationships include: associated with, regulates, implicated in. Associated with ALS, Als, Ms. Connected to 29 entities in the SciDEX knowledge graph.
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| Gene Symbol | RAB11B |
| Full Name | RAB11B |
| Aliases | Page for RAB11B |
| Chromosome | 19p13.2 |
| Function | RAB11B is a small GTPase that cycles between an active (GTP-bound) and inactive (GDP-bound) state. |
| Primary Expression | Brain, Neurons, Neurosecretory cells |
| Molecular Weight | 24 kDa |
| Amino Acids | 218 aa |
| Pathways | pathway: **Receptor Recycling** |
| UniProt ID | Q9UQ90 |
| NCBI Gene ID | 5876 |
| Ensembl ID | ENSG00000185236 |
| GeneCards | RAB11B |
| Human Protein Atlas | RAB11B |
| Associated Diseases | Als |
| Interactions | MAP1LC3B |
| KG Connections | 31 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
RAB11B["RAB11B"]
Als{"Als"}
RAB11B -->|"associated with"| Als
Ms{"Ms"}
RAB11B -->|"regulates"| Ms
ALS{"ALS"}
RAB11B -->|"associated with"| ALS
RAB10["RAB10"]
RAB11B -->|"associated with"| RAB10
RAB3A["RAB3A"]
RAB11B -->|"associated with"| RAB3A
Exocytosis(["Exocytosis"])
RAB11B -->|"associated with"| Exocytosis
RAB3C["RAB3C"]
RAB11B -->|"associated with"| RAB3C
RAB5A["RAB5A"]
RAB11B -->|"associated with"| RAB5A
RAB5["RAB5"]
RAB11B -->|"associated with"| RAB5
RAB27B["RAB27B"]
RAB11B -->|"associated with"| RAB27B
RAB3B["RAB3B"]
RAB11B -->|"associated with"| RAB3B
RAB4B["RAB4B"]
RAB11B -->|"associated with"| RAB4B
RAB4B -->|"associated with"| RAB11B
RAB27B -->|"associated with"| RAB11B
RAB3C -->|"associated with"| RAB11B
RAB5 -->|"associated with"| RAB11B
RAB3B -->|"associated with"| RAB11B
RAB5A -->|"associated with"| RAB11B
RAB3A -->|"associated with"| RAB11B
RAB10 -->|"associated with"| RAB11B
ATP1A1["ATP1A1"]
ATP1A1 -->|"regulates"| RAB11B
MAP1LC3B["MAP1LC3B"]
MAP1LC3B -->|"activates"| RAB11B
style RAB11B fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Als | associated_with | disease | 0.65 |
| Als | transports | disease | 0.65 |
| Ms | regulates | disease | 0.65 |
| ALS | associated_with | disease | 0.65 |
| APOPTOSIS | regulates | gene | 0.60 |
| Fus | associated_with | protein | 0.60 |
| App | associated_with | protein | 0.60 |
| Immune Response | regulates | pathway | 0.60 |
| Apoptosis | regulates | pathway | 0.60 |
| AMBRA1 | regulates | gene | 0.60 |
| SORT1 | regulates | gene | 0.60 |
| RAB3A | associated_with | gene | 0.60 |
| RAB3C | associated_with | gene | 0.60 |
| RAB5A | associated_with | gene | 0.60 |
| RAB5 | associated_with | gene | 0.60 |
| RAB27B | associated_with | gene | 0.60 |
| RAB3B | associated_with | gene | 0.60 |
| RAB4B | associated_with | gene | 0.60 |
| Synaptic Vesicle | associated_with | pathway | 0.60 |
| RAB10 | associated_with | gene | 0.60 |
| Exocytosis | associated_with | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| RAB4B | associated_with | gene | 0.60 |
| RAB27B | associated_with | gene | 0.60 |
| RAB3C | associated_with | gene | 0.60 |
| RAB5 | associated_with | gene | 0.60 |
| RAB3B | associated_with | gene | 0.60 |
| RAB5A | associated_with | gene | 0.60 |
| RAB3A | associated_with | gene | 0.60 |
| RAB10 | associated_with | gene | 0.60 |
| ATP1A1 | regulates | gene | 0.60 |
| MAP1LC3B | activates | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning RAB11B in their description or question text
No additional research found